{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:43:22Z","timestamp":1789469002452,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","award":["pC ID 460399"],"award-info":[{"award-number":["pC ID 460399"]}],"id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bladder dysfunction is a major complication after spinal cord injury (SCI) and effective treatment remains challenging. Neurogenic bladder can be difficult to treat because of its heterogeneous and dynamic symptoms. We aimed to (1) characterize heterogeneity in bladder recovery from acute to chronic phases and (2) predict chronic urinary function using early urodynamic parameters. We performed continuous longitudinal urodynamic monitoring in 10 complete T9 SCI and 10 control rats over 4\u2009weeks. A novel metabolic cage system enabled 24\/7 tracking of voiding behavior. Key parameters, including voiding efficiency (VE), post\u2010void residual (PVR), and ureter flow rate (UFR), were measured continuously throughout recovery. Unsupervised clustering identified three distinct spinally mediated reflexive voiding phenotypes in the chronic phase (days 20\u201330), defined by VE and PVR: good (robust efficient voiding), moderate (partial voiding efficiency), and poor (minimal voiding efficiency). No single acute\u2010phase urodynamic parameter (3\u201310\u2009days post\u2010injury) differed significantly between phenotypes. In contrast, multivariate generalized linear models incorporating parameter interactions, particularly VV\u2009\u00d7\u2009VE and UFR\u2009\u00d7\u2009VE\n                    <jats:sup>2<\/jats:sup>\n                    , predicted chronic phenotype with high accuracy (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These findings underscore the prognostic importance of interactions among early urodynamic features in determining the severity of long\u2010term neurogenic bladder outcomes after SCI and identify a critical window for individualized intervention.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71101","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:13:06Z","timestamp":1789020786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early urodynamic profiles predict lower urinary tract recovery after spinal cord injury in female rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-4268","authenticated-orcid":false,"given":"Behnaz","family":"Afrashteh","sequence":"first","affiliation":[{"name":"Division of Physical Therapy, Department of Rehabilitation Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steafan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabeya Zinnat","family":"Adury","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Angoli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-1259","authenticated-orcid":false,"given":"Zachary C.","family":"Danziger","sequence":"additional","affiliation":[{"name":"Division of Physical Therapy, Department of Rehabilitation Medicine Emory University  Atlanta Georgia USA"},{"name":"Department of Biomedical Engineering Florida International University  Miami Florida USA"},{"name":"Wallace H. Coulter Department of Biomedical Engineering Emory University and Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0521"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00349.2019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0498-1"},{"key":"e_1_2_12_6_1","volume-title":"Model selection and multimodel inference: A practical information\u2010theoretic approach","author":"Burnham K. P.","year":"2003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11129"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00516.2015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00587-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)52005-3"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20761"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","unstructured":"Dietz N. Jaganathan V. Alkin V. Mettille J. Boakye M. &Drazin D.(2022).Machine learning in clinical diagnosis prognostication and management of acute traumatic spinal cord injury (SCI): A systematic review 35 102046.","DOI":"10.1016\/j.jcot.2022.102046"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101603"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4294"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0328-18.2018"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000104116.91462.CD"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002235"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2017.11.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.071"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/neur.2021.0046"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00156.2022"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012298"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0997"},{"issue":"1","key":"e_1_2_12_25_1","first-page":"95","article-title":"Functional outcome prediction after spinal cord injury using ensemble machine learning","volume":"105","author":"Kato C.","year":"2024","journal-title":"J Aopm, Rehabilitation"},{"key":"e_1_2_12_26_1","unstructured":"Kearney K.(2025).boundedline.m.https:\/\/github.com\/kakearney\/boundedline\u2010pkg"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/08977151251401550"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.025833"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360271"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13030705"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21003"},{"issue":"2","key":"e_1_2_12_32_1","first-page":"89","article-title":"Changes of rat urinary bladder during acute phase of spinal cord injury","volume":"51","author":"Mimata H.","year":"1993","journal-title":"Urologia Internationalis"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003611"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00072.2022"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00070-8"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002041"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000199"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013469"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00622.2020"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10121316"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.597689"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S29644"},{"issue":"1","key":"e_1_2_12_44_1","first-page":"S6","article-title":"Renal physiology of nocturia","volume":"33","author":"Verbalis J. G.","year":"2014","journal-title":"Neurourology and Urodynamics"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005852"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.206"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.71101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:21:32Z","timestamp":1789464092000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.71101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.14814\/phy2.71101"],"URL":"https:\/\/doi.org\/10.14814\/phy2.71101","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71101"}}