{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:50:40Z","timestamp":1791960640465,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011129","name":"North Dakota Agricultural Experiment Station","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our objective was to evaluate body composition and muscle insulin receptor concentration resulting from consumption of a low\u2010carbohydrate, high\u2010fat diet using swine as a surrogate for humans. Two treatments, a control standard swine feed (CON;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097) and test diet where beef tallow replaced the corn carbohydrate (LCHF;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098), were fed for 32\u2009days to post\u2010pubertal gilts (Landrace \u00d7 Yorkshire). Body weight (BW), subcutaneous fat (FD), daily gain (ADG), daily feed intake (ADFI), and fasting blood chemistry were measured. Organ weights, and pancreas, longissimus, and semimembranosus samples were collected from three gilts per treatment. LCHF gilts had reduced ADG, ADFI, FD, and visceral fat (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.09, 0.04, 0.06, and 0.03; respectively) with similar BW (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.18). Blood chemistry parameters were not affected but for fasting glucose, which tended to be higher for LCHF (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.054). The percentage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.09) and number (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07) of active pancreatic \u03b2\u2010cells tended to be higher for LCHF gilts, as was the concentration of semimembranosus insulin receptors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Short\u2010term consumption of a low\u2010carb, high\u2010fat diet improved body composition, insulin production mechanics, and muscle insulin receptor density in a swine biomedical model.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71124","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:35:45Z","timestamp":1790735745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does a low\u2010carb, high\u2010fat diet change muscle insulin receptor concentration and body composition in a swine biomedical model?"],"prefix":"10.14814","volume":"14","author":[{"given":"Natalie","family":"Acosta\u2010Castellanos","sequence":"first","affiliation":[{"name":"Department of Animal Sciences North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Tiede","sequence":"additional","affiliation":[{"name":"Ralco Agriculture  Marshall Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Borowicz","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-6279","authenticated-orcid":false,"given":"Eric P.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University  Fargo 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