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We previously reported that 12\u2009weeks of high\u2010phosphate diet (HPD) reduced VO\n                    <jats:sub>2max<\/jats:sub>\n                    and altered metabolic gene expression and mitochondrial dysfunction in mouse skeletal muscle. Here, we investigated whether exercise training reverses the negative consequences of HPD. Male mice were fed normal (NPD) or HPD for 5\u2009weeks, then continued on NPD or HPD with 9\u2009weeks of voluntary exercise training. Serum, urine, and fecal phosphate increased within 1\u2009day of HPD\u2010feeding and remained elevated throughout the study. Trained NPD\u2010 and HPD\u2010fed mice performed similarly on forced exercise tests, but mitochondrial respiration was significantly decreased in skeletal muscle from trained HPD\u2010fed mice. RNA sequencing revealed distinct sets of differentially expressed genes when comparing sedentary versus exercise\u2010trained muscle of HPD\u2010fed mice relative to the same comparison in NPD\u2010fed mice. These findings indicate that voluntary exercise training preserves endurance but does not fully restore gene expression or mitochondrial function in muscle from HPD\u2010fed mice. Thus, HPD\u2010induced skeletal muscle dysregulation is not completely reversible with exercise, underscoring the importance of both diet and exercise for metabolic health.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71139","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:45:01Z","timestamp":1792478701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise training does not mitigate high\u2010phosphate diet\u2010induced mitochondrial dysfunction in skeletal muscle in male mice"],"prefix":"10.14814","volume":"14","author":[{"given":"Hannah F.","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic W.","family":"Kolonay","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade A.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella R.","family":"Dobrski","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Branch","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas A.","family":"Lefers","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamen H.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-9655","authenticated-orcid":false,"given":"Kedryn K.","family":"Baskin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology The Ohio State University  Columbus Ohio USA"},{"name":"Dorothy M. 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