{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:50:38Z","timestamp":1791960638118,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Resistance training (RT)\u2010induced hypertrophy is attenuated with aging, albeit the proteomic basis of this attenuation remains unclear. We thus determined whether reduced skeletal muscle proteome plasticity accompanies age\u2010related blunted hypertrophic responses. Seventeen younger (21.9\u2009\u00b1\u20092.5\u2009years) and 15 older (57.5\u2009\u00b1\u20096.9\u2009years) untrained males completed 10\u201312\u2009weeks of RT, and the vastus lateralis (VL) soluble proteome was profiled pre\u2010 and post\u2010training using data\u2010independent acquisition mass spectrometry (2106 proteins). Despite similar training volume (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.771), younger adults gained more lean body mass (+2.73 vs. +1.18\u2009kg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) and VL thickness (+0.49 vs. +0.20\u2009cm,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) than older adults. Proteome plasticity paralleled this divergence, as RT altered 135 proteins (FDR &lt; 0.05) in younger adults and none in older adults. This attenuation was one of magnitude rather than direction, as 81.5% of the 135 younger\u2010adult proteins shifted concordantly in older adults (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.711), and 75 gene sets were enriched with RT in older adults, led by translational machinery (NES up to +2.85). At baseline, 278 proteins differed between age groups (FDR &lt;0.05), and age dominated the co\u2010expression network (Turquoise module AUC\u2009=\u20090.96). In conclusion, the blunted hypertrophic response of older males coincides with a loss of RT\u2010induced proteome plasticity, reflecting a compressed rather than qualitatively altered RT adaptation.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71141","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:16:36Z","timestamp":1791782196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging concomitantly reduces skeletal muscle proteome plasticity and hypertrophic responses to resistance training in male adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Dustyn T.","family":"Lewis","sequence":"first","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Max","family":"Michel","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason C.","family":"McIntosh","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakota R.","family":"Tiede","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Plotkin","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison L.","family":"Mattingly","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Kontos","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"George","family":"Kontos","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel C.","family":"Norton","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Godwin","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J.","family":"Schoenfeld","sequence":"additional","affiliation":[{"name":"Department of Exercise Science and Recreation, Applied Muscle Development Laboratory CUNY Lehman College  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Frug\u00e9","sequence":"additional","affiliation":[{"name":"College of Nursing Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Brooks","family":"Mobley","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas N.","family":"Kavazis","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-5362","authenticated-orcid":false,"given":"Michael D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"},{"name":"Edward Via College of Osteopathic Medicine \u2013 Auburn Campus  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.12.021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9993.2001.01070.pp.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9384-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272857"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31182"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01883"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00658-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00736"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13285"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00596.2022"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-1165"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2026.103276"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP288104"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115750"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.70175"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.03.009"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533558"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00154.2020"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-025-00318-w"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13030255"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2015.02.015"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00195.2025"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000465"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003508"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06877-w"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.054"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.02.012"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(62)90116-9"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP092328"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.615849"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.03.004"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181eb6265"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00435.2011"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"issue":"8","key":"e_1_2_12_42_1","first-page":"6631","article-title":"A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training","volume":"16","author":"Roberts M. 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