{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:42:48Z","timestamp":1792212168521,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We tested whether dim\u2010light melatonin onset (DLMO) is time\u2010aligned with the transition between biological day into night in cardiovascular autonomic control (CV onset time). We studied 10 healthy adults (4 females, age 25\u2009\u00b1\u2009SD 2\u2009years) under an ultra\u2010short semi\u2010constant routine protocol (&lt;8lux). Participants remained seated for 7\u2009h until 1\u2009h after their habitual bedtime. We collected saliva samples every 30\u2009min and recorded R\u2010R intervals and beat\u2010to\u2010beat blood pressure every hour. DLMO was defined as the interpolated time for melatonin increase over 3\u2009pg\/mL. Phase angle was defined as the time difference between DLMO and the midpoint of self\u2010reported sleep as a measure of the alignment between sleep\u2013wake patterns and biological circadian rhythms. CV onset time was defined using a segmental (piecewise) analysis to identify the inflection point (X\n                    <jats:sub>0<\/jats:sub>\n                    slope) throughout the study. CV autonomic modulation was assessed using indices of heart rate and blood pressure variability. CV onset times for all indices did not differ significantly from DLMO (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Mean differences between DLMO and CV onset time were significantly correlated with the phase angle of entrainment (all significant,\n                    <jats:italic>r<\/jats:italic>\n                    \u2009&gt;\u2009+0.75). Our results suggest that CV autonomic transition into biological night was not associated with DLMO, which seems to depend on the phase angle of entrainment.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71145","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:16:41Z","timestamp":1792210601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is cardiovascular autonomic control during the day\u2010to\u2010night transition dependent on dim light melatonin onset? An exploratory analysis in healthy adults"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-7390","authenticated-orcid":false,"given":"Leandro C.","family":"Brito","sequence":"first","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Jones","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline P.","family":"Garc\u00eas","sequence":"additional","affiliation":[{"name":"Exercise, Women and Cardiometabolic Health Research Group, Faculty of Physical Education and Physical Therapy Federal University of Uberlandia  Uberlandia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Shea","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-4340","authenticated-orcid":false,"given":"Saurabh S.","family":"Thosar","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"School of Nursing Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"OHSU\u2010PSU School of Public Health Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Knight Cardiovascular Institute Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5664\/jcsm.27083","article-title":"Measuring melatonin in humans","volume":"4","author":"Benloucif S.","year":"2008","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1113\/JP285966","article-title":"Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension","volume":"602","author":"Brito L. 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