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ICA CVR is blunted with aging; however, it is not known whether age\u2010related reductions in ICA CVR are influenced by antioxidant\u2010responsive mechanisms. The purpose of this study was to determine whether infusion of the antioxidant, ascorbic acid (AA) restores ICA CVR in middle\u2010aged and older (MA\/O) adults. We also examined the effect of AA on middle cerebral artery (MCA) CVR to sustained (3\u2010min) hypercapnia. We hypothesized that MA\/O adults would exhibit lower cerebrovascular function compared to young (Y) adults, and that infusion of AA would improve cerebrovascular function in MA\/O adults, whereas infusion of saline (SAL) would not. The primary analytic sample included nine Y adults (25\u2009\u00b1\u20092\u2009years) and nineteen (65\u2009\u00b1\u20096\u2009years) MA\/O adults, with analyzable data varying by outcome. ICA CVR was measured using high\u2010resolution duplex ultrasound, and MCA CVR was measured using transcranial Doppler ultrasound. AA infusion improved ICA CVR and MCA CVR in MA\/O adults but had no effect in Y adults. These findings suggest that age\u2010related impairments in cerebrovascular function may be partly attributable to mechanisms responsive to acute, supraphysiological AA administration.<\/jats:p>","DOI":"10.14814\/phy2.71120","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:51:48Z","timestamp":1791183108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supraphysiological ascorbic acid infusion attenuates cerebrovascular dysfunction in middle\u2010aged and older adults"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-6499","authenticated-orcid":false,"given":"Theodore M.","family":"DeConne","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria","family":"Sanjana","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Habash","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Decker","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-2948","authenticated-orcid":false,"given":"Christopher R.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20301"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202673"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm\u20102021\u20100220"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12606"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13572"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010314"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.3.9844657"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2016.0001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP089446"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280369"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197055"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010022\u201001142\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00761.2014"},{"key":"e_1_2_10_16_1","unstructured":"Delis D. 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