{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:59:26Z","timestamp":1792155566326,"version":"4.4.0"},"reference-count":42,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The neuroanatomic basis of affective processing deficits in Huntington disease is insufficiently understood. We investigated whether Huntington disease\u2013related deficits in emotion recognition and experience are associated with specific changes in grey matter volume. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> We assessed grey matter volume in symptomatic patients with Huntington disease and healthy controls using voxel-based morphometry, and we correlated regional grey matter volume with participants\u2019 affective ratings. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We enrolled 18 patients with Huntington disease and 18 healthy controls in our study. Patients with Huntington disease showed normal affective experience but impaired recognition of negative emotions (disgust, anger, sadness). The patients perceived the emotions as less intense and made more classification errors than controls. These deficits were correlated with regional atrophy in emotion-relevant areas (insula, orbitofrontal cortex) and in memory-relevant areas (dorsolateral prefrontal cortex, hippocampus). <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> Our study was limited by the small sample size and the resulting modest statistical power relative to the number of tests. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Our study sheds new light on the importance of a cognitive\u2013affective brain circuit involved in the affect recognition impairment in patients with Huntington disease. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.100143","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T11:31:14Z","timestamp":1319110274000},"page":"383-390","source":"Crossref","is-referenced-by-count":50,"title":["Emotion recognition and experience in Huntington disease: a voxel-based morphometry study"],"prefix":"10.1139","volume":"36","author":[{"given":"Rottraut","family":"Ille","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology, University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Scharm\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Enzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmuth","family":"Sch\u00f6ggl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Kapfhammer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schienle","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, University of Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-0360383\/b1-0360383_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Disord"},{"key":"b2-0360383\/b2-0360383_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/jnp.13.3.342","volume":"13","author":"Nehl C","year":"2001","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"b3-0360383\/b3-0360383_1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/brain\/awh165","volume":"127","author":"Hennenlotter A","year":"2004","journal-title":"Brain"},{"key":"b4-0360383\/b4-0360383_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1076\/jcen.20.4.565.1468","volume":"20","author":"Zakzanis KK","year":"1998","journal-title":"J Clin Exp Neuropsychol"},{"key":"b5-0360383\/b5-0360383_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ana.20684","volume":"59","author":"Feigin A","year":"2006","journal-title":"Ann Neurol"},{"key":"b6-0360383\/b6-0360383_1","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awm210","volume":"130","author":"Wolf RC","year":"2007","journal-title":"Brain"},{"key":"b7-0360383\/b7-0360383_1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.neuroimage.2006.05.057","volume":"32","author":"Douaud G","year":"2006","journal-title":"Neuroimage"},{"key":"b8-0360383\/b8-0360383_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/jnnp.2009.190702","volume":"81","author":"Hobbs NZ","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"b9-0360383\/b9-0360383_1","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/brain\/awm107","volume":"130","author":"Johnson SA","year":"2007","journal-title":"Brain"},{"key":"b10-0360383\/b10-0360383_1","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/brain\/120.11.2029","volume":"120","author":"Gray JM","year":"1997","journal-title":"Brain"},{"key":"b11-0360383\/b11-0360383_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuropsychologia.2005.07.003","volume":"44","author":"Sprengelmeyer R","year":"2006","journal-title":"Neuropsychologia"},{"key":"b12-0360383\/b12-0360383_1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/S0028-3932(03)00079-4","volume":"41","author":"Milders M","year":"2003","journal-title":"Neuropsychologia"},{"key":"b13-0360383\/b13-0360383_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000093215","volume":"55","author":"Montagne B","year":"2006","journal-title":"Eur Neurol"},{"key":"b14-0360383\/b14-0360383_1","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.neuropsychologia.2008.02.025","volume":"46","author":"Henley SM","year":"2008","journal-title":"Neuropsychologia"},{"key":"b15-0360383\/b15-0360383_1","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1016\/j.neuropsychologia.2008.04.018","volume":"46","author":"Snowden JS","year":"2008","journal-title":"Neuropsychologia"},{"key":"b16-0360383\/b16-0360383_1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/brain\/119.5.1647","volume":"119","author":"Sprengelmeyer R","year":"1996","journal-title":"Brain"},{"key":"b17-0360383\/b17-0360383_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0028-3932(02)00171-9","volume":"41","author":"Wang K","year":"2003","journal-title":"Neuropsychologia"},{"key":"b18-0360383\/b18-0360383_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/39051","volume":"389","author":"Phillips ML","year":"1997","journal-title":"Nature"},{"key":"b19-0360383\/b19-0360383_1","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1098\/rspb.1998.0522","volume":"265","author":"Sprengelmeyer R","year":"1998","journal-title":"Proc Biol Sci"},{"key":"b20-0360383\/b20-0360383_1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1162\/jocn.2007.19.7.1206","volume":"19","author":"Kipps CM","year":"2007","journal-title":"J Cogn Neurosci"},{"key":"b21-0360383\/b21-0360383_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1097\/00001756-200211150-00006","volume":"13","author":"Schienle A","year":"2002","journal-title":"Neuroreport"},{"key":"b22-0360383\/b22-0360383_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuropsychologia.2006.10.015","volume":"45","author":"Hayes CJ","year":"2007","journal-title":"Neuropsychologia"},{"key":"b23-0360383\/b23-0360383_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijpsycho.2005.01.011","volume":"57","author":"Sch\u00e4fer A","year":"2005","journal-title":"Int J Psychophysiol"},{"key":"b24-0360383\/b24-0360383_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpsycho.2004.12.013","volume":"57","author":"Schienle A","year":"2005","journal-title":"Int J Psychophysiol"},{"key":"b25-0360383\/b25-0360383_1","volume-title":"Beck Depression Inventory [German version]","author":"Hautzinger M","year":"1994"},{"key":"b26-0360383\/b26-0360383_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1097\/00001756-200211150-00006","volume":"13","author":"Schienle A","year":"2002","journal-title":"Neuroreport"},{"key":"b27-0360383\/b27-0360383_1","volume-title":"State Trait Angstinventar (STAI)","author":"Laux L","year":"1981"},{"key":"b28-0360383\/b28-0360383_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-2000-11799","volume":"68","author":"Ihl R","year":"2000","journal-title":"Fortschr Neurol Psychiatr"},{"key":"b29-0360383\/b29-0360383_1","volume-title":"The Karolinska Directed Emotional Faces","author":"Lundquist D","year":"1998"},{"key":"b30-0360383\/b30-0360383_1","volume-title":"International Affective Picture System","author":"Lang PJ","year":"2001"},{"key":"b31-0360383\/b31-0360383_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","volume":"11","author":"Ashburner J","year":"2000","journal-title":"Neuroimage"},{"key":"b32-0360383\/b32-0360383_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1109\/TMI.2007.906087","volume":"27","author":"Coupe P","year":"2008","journal-title":"IEEE Trans Med Imaging"},{"key":"b33-0360383\/b33-0360383_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1109\/42.563663","volume":"16","author":"Rajapakse JC","year":"1997","journal-title":"IEEE Trans Med Imaging"},{"key":"b34-0360383\/b34-0360383_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroimage.2004.05.007","volume":"23","author":"Tohka J","year":"2004","journal-title":"Neuroimage"},{"key":"b35-0360383\/b35-0360383_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"Ashburner J","year":"2007","journal-title":"Neuroimage"},{"key":"b36-0360383\/b36-0360383_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","volume":"15","author":"Tzourio-Mazoyer N","year":"2002","journal-title":"Neuroimage"},{"key":"b37-0360383\/b37-0360383_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","volume":"19","author":"Maldjian JA","year":"2003","journal-title":"Neuroimage"},{"key":"b38-0360383\/b38-0360383_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J R Statist Soc B"},{"key":"b39-0360383\/b39-0360383_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.conb.2004.03.015","volume":"14","author":"Phelps EA","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"b40-0360383\/b40-0360383_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tics.2007.06.001","volume":"11","author":"Moll J","year":"2007","journal-title":"Trends Cogn Sci"},{"key":"b41-0360383\/b41-0360383_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/mds.1056","volume":"16","author":"Helder DI","year":"2001","journal-title":"Mov Disord"},{"key":"b42-0360383\/b42-0360383_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/13682820903105145","volume":"45","author":"Hartelius L","year":"2010","journal-title":"Int J Lang Commun Disord"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.100143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.100143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:36:21Z","timestamp":1756830981000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.100143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1503\/jpn.100143"],"URL":"https:\/\/doi.org\/10.1503\/jpn.100143","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}