{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:38:02Z","timestamp":1791121082910,"version":"4.1.0"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is evidence to suggest that obsessive\u2013compulsive disorder (OCD) is associated with structural abnormalities in cortico\u2013striato\u2013thalamic circuits, yet the extent of white matter abnormalities is not well established. In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with OCD and sex-, age- and IQ-matched healthy controls underwent DTI. The primary objective was to explore whether patients with OCD had white matter abnormalities in the anterior limb of the internal capsule (ALIC), the uncinate fasciculus, the genu of the corpus callosum and the cingulum. The secondary objective was to evaluate the relation between fractional anisotropy and mean diffusivity in these ROIs and other clinical variables (including age at onset of OCD, OCD severity and levels of depressive and anxiety symptomatology) in patients with OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 15 patients and 17 controls enrolled in our study. Compared with healthy controls, patients with OCD showed increased fractional anisotropy in bilateral regions of the ALIC adjacent to the body of the caudate, as well as decreased fractional anisotropy in the right anterior limb near the head of the caudate. Patients also had decreased mean diffusivity in the body of the right cingulum and the left anterior cingulum compared with controls. Correlational analyses revealed significant associations of fractional anisotropy and mean diffusivity in select circuits with OCD, depression and anxiety severity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Inclusion of patients with OCD receiving pharmacotherapy may have been a limitation. In addition, the patients were heterogeneous in terms of their obsessive\u2013compulsive symptom profiles; we did not distinguish between different obsessive\u2013compulsive symptom dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study results provide further evidence for OCD-related white matter abnormalities in the ALIC and cingulum, consistent with a corticostriatal model of OCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1503\/jpn.110059","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T09:52:27Z","timestamp":1334915547000},"page":"193-199","source":"Crossref","is-referenced-by-count":83,"title":["Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive\u2013compulsive disorder"],"prefix":"10.1139","volume":"37","author":[{"given":"Christine","family":"Lochner","sequence":"first","affiliation":[{"name":"MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Fouch\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Stellenbosch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan du","family":"Plessis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Stellenbosch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Spottiswoode","sequence":"additional","affiliation":[{"name":"MRC\/UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, and the Division of Radiology, University of Stellenbosch, South 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