{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:32:33Z","timestamp":1790811153428,"version":"4.1.0"},"reference-count":193,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological processes and whose dysfunction may contribute to several different diseases, such as neurodegenerative diseases, circadian and mood disorders, insomnia, type 2 diabetes and pain. Melatonin is synthesized by the pineal gland during the night and acts through 2 G-protein coupled receptors (GPCRs), MT\n                      <jats:sub>1<\/jats:sub>\n                      (MEL1a) and MT\n                      <jats:sub>2<\/jats:sub>\n                      (MEL1b). Although a bulk of research has examined the physiopathological effects of MLT, few studies have investigated the selective role played by MT\n                      <jats:sub>1<\/jats:sub>\n                      and MT\n                      <jats:sub>2<\/jats:sub>\n                      receptors. Here we have reviewed current knowledge about the implications of MT\n                      <jats:sub>2<\/jats:sub>\n                      receptors in brain functions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Web of Science, Scopus, Google Scholar and articles reference lists for studies on MT\n                      <jats:sub>2<\/jats:sub>\n                      receptor ligands in sleep, anxiety, neuropsychiatric diseases and psychopharmacology, including genetic studies on the MTNR1B gene, which encodes the melatonin MT\n                      <jats:sub>2<\/jats:sub>\n                      receptor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      These studies demonstrate that MT\n                      <jats:sub>2<\/jats:sub>\n                      receptors are involved in the pathophysiology and pharmacology of sleep disorders, anxiety, depression, Alzheimer disease and pain and that selective MT\n                      <jats:sub>2<\/jats:sub>\n                      receptor agonists show hypnotic and anxiolytic properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>\n                      Studies examining the role of MT\n                      <jats:sub>2<\/jats:sub>\n                      receptors in psychopharmacology are still limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The development of novel selective MT\n                      <jats:sub>2<\/jats:sub>\n                      receptor ligands, together with further preclinical in vivo studies, may clarify the role of this receptor in brain function and psychopharmacology. The superfamily of GPCRs has proven to be among the most successful drug targets and, consequently, MT\n                      <jats:sub>2<\/jats:sub>\n                      receptors have great potential for pioneer drug discovery in the treatment of mental diseases for which limited therapeutic targets are currently available.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1503\/jpn.130009","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T10:32:24Z","timestamp":1389004344000},"page":"6-21","source":"Crossref","is-referenced-by-count":151,"title":["CCNP Award Paper: Unveiling the role of melatonin MT\n                    <sub>2<\/sub>\n                    receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology"],"prefix":"10.1139","volume":"39","author":[{"given":"Stefano","family":"Comai","sequence":"first","affiliation":[{"name":"Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Centre, Montr\u00e9al, Que., Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Centre, Montr\u00e9al, Que., Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-jpn-39-6\/b1-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2265.1988.tb00263.x","volume":"29","author":"Arendt J","year":"1988","journal-title":"Clin Endocrinol (Oxf)"},{"key":"b2-jpn-39-6\/b2-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1749-6632.1985.tb11811.x","volume":"453","author":"Waldhauser F","year":"1985","journal-title":"Ann N Y Acad Sci"},{"key":"b3-jpn-39-6\/b3-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1521-690X(03)00016-2","volume":"17","author":"Reiter RJ","year":"2003","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"b4-jpn-39-6\/b4-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","volume":"93","author":"Hardeland R","year":"2011","journal-title":"Prog Neurobiol"},{"key":"b5-jpn-39-6\/b5-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/pr.110.002832","volume":"62","author":"Dubocovich ML","year":"2010","journal-title":"Pharmacol Rev"},{"key":"b6-jpn-39-6\/b6-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/B0-08-045044-X\/00062-6","volume-title":"Comprehensive Medicinal Chemistry II","author":"Thomsen WJ","year":"2007"},{"key":"b7-jpn-39-6\/b7-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"31311","DOI":"10.1074\/jbc.M005141200","volume":"275","author":"Nosjean O","year":"2000","journal-title":"J Biol Chem"},{"key":"b8-jpn-39-6\/b8-jpn-39-6_1","author":"Rivara S","year":"2012","journal-title":"ChemMedChem"},{"key":"b9-jpn-39-6\/b9-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/13543776.2010.496455","volume":"20","author":"Mor M","year":"2010","journal-title":"Expert Opin Ther Pat"},{"key":"b10-jpn-39-6\/b10-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0024-3205(02)02256-7","volume":"72","author":"Kondoh T","year":"2002","journal-title":"Life Sci"},{"key":"b11-jpn-39-6\/b11-jpn-39-6_1","first-page":"323","volume":"84","author":"Liu RY","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"b12-jpn-39-6\/b12-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1023\/A:1015187601628","volume":"21","author":"Zisapel N","year":"2001","journal-title":"Cell Mol Neurobiol"},{"key":"b13-jpn-39-6\/b13-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-079X.2004.00194.x","volume":"38","author":"Genovese T","year":"2005","journal-title":"J Pineal Res"},{"key":"b14-jpn-39-6\/b14-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1749-6632.2002.tb04226.x","volume":"966","author":"Maestroni GJ","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"b15-jpn-39-6\/b15-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1468-2982.2005.00889.x","volume":"25","author":"Peres MF","year":"2005","journal-title":"Cephalalgia"},{"key":"b16-jpn-39-6\/b16-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.preteyeres.2005.01.003","volume":"24","author":"Iuvone PM","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"b17-jpn-39-6\/b17-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-079X.1997.tb00297.x","volume":"22","author":"Cagnacci A","year":"1997","journal-title":"J Pineal Res"},{"key":"b18-jpn-39-6\/b18-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(98)00064-8","volume":"345","author":"Doolen S","year":"1998","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"b19-jpn-39-6\/b19-jpn-39-6_1","first-page":"79","volume":"23","author":"Sewerynek E","year":"2002","journal-title":"Neuroendocrinol Lett"},{"key":"b20-jpn-39-6\/b20-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2174\/1568026023394407","volume":"2","author":"Blask DE","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"b21-jpn-39-6\/b21-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00702-004-0270-4","volume":"112","author":"Sofic E","year":"2005","journal-title":"J Neural Transm"},{"key":"b22-jpn-39-6\/b22-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1073\/pnas.92.19.8734","volume":"92","author":"Reppert SM","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b23-jpn-39-6\/b23-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0006-2952(99)00134-3","volume":"58","author":"Petit L","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"b24-jpn-39-6\/b24-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","volume":"309","author":"von Gall C","year":"2002","journal-title":"Cell Tissue Res"},{"key":"b25-jpn-39-6\/b25-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0024-3205(03)00098-5","volume":"72","author":"Witt-Enderby PA","year":"2003","journal-title":"Life Sci"},{"key":"b26-jpn-39-6\/b26-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","volume":"27","author":"Dubocovich ML","year":"2005","journal-title":"Endocrine"},{"key":"b27-jpn-39-6\/b27-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0169-328X(96)00017-4","volume":"39","author":"Mazzucchelli C","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"b28-jpn-39-6\/b28-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.lfs.2004.08.016","volume":"76","author":"Sallinen P","year":"2005","journal-title":"Life Sci"},{"key":"b29-jpn-39-6\/b29-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hipo.1105","volume":"12","author":"Musshoff U","year":"2002","journal-title":"Hippocampus"},{"key":"b30-jpn-39-6\/b30-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.anl.2011.09.007","volume":"39","author":"Ahn SK","year":"2012","journal-title":"Auris Nasus Larynx"},{"key":"b31-jpn-39-6\/b31-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","volume":"60","author":"Ekmekcioglu C","year":"2006","journal-title":"Biomed Pharmacother"},{"key":"b32-jpn-39-6\/b32-jpn-39-6_1","first-page":"199","volume":"44","author":"Angeloni D","year":"2000","journal-title":"Eur J Histochem"},{"key":"b33-jpn-39-6\/b33-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1523\/JNEUROSCI.2676-11.2011","volume":"31","author":"Ochoa-Sanchez R","year":"2011","journal-title":"J Neurosci"},{"key":"b34-jpn-39-6\/b34-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"C110","DOI":"10.1152\/ajpcell.2001.280.1.C110","volume":"280","author":"Hunt AE","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"b35-jpn-39-6\/b35-jpn-39-6_1","author":"Wu YH","journal-title":"J Affect Disord"},{"key":"b36-jpn-39-6\/b36-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/8062","volume":"2","author":"Wan Q","year":"1999","journal-title":"Nat Neurosci"},{"key":"b37-jpn-39-6\/b37-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(00)80350-5","volume":"19","author":"Liu C","year":"1997","journal-title":"Neuron"},{"key":"b38-jpn-39-6\/b38-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.physiol.63.1.647","volume":"63","author":"Reppert SM","year":"2001","journal-title":"Annu Rev Physiol"},{"key":"b39-jpn-39-6\/b39-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/2011134a0","volume":"201","author":"Axelrod J","year":"1964","journal-title":"Nature"},{"key":"b40-jpn-39-6\/b40-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1128\/MCB.23.3.1054-1060.2003","volume":"23","author":"Jin X","year":"2003","journal-title":"Mol Cell Biol"},{"key":"b41-jpn-39-6\/b41-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/07420528.2012.667859","volume":"29","author":"Pfeffer M","year":"2012","journal-title":"Chronobiol Int"},{"key":"b42-jpn-39-6\/b42-jpn-39-6_1","first-page":"1478","volume":"10","author":"Weaver DR","year":"1996","journal-title":"Mol Endocrinol"},{"key":"b43-jpn-39-6\/b43-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.sleep.2007.10.007","volume":"8","author":"Dubocovich ML","year":"2007","journal-title":"Sleep Med"},{"key":"b44-jpn-39-6\/b44-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1021\/jm700957j","volume":"50","author":"Rivara S","year":"2007","journal-title":"J Med Chem"},{"key":"b45-jpn-39-6\/b45-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.2174\/092986712801323153","volume":"19","author":"Zlotos DP","year":"2012","journal-title":"Curr Med Chem"},{"key":"b46-jpn-39-6\/b46-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/jm980684+","volume":"43","author":"Faust R","year":"2000","journal-title":"J Med Chem"},{"key":"b47-jpn-39-6\/b47-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/PL00004956","volume":"355","author":"Dubocovich ML","year":"1997","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"b48-jpn-39-6\/b48-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00210-003-0751-2","volume":"367","author":"Audinot V","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"b49-jpn-39-6\/b49-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2009.04.005","volume":"457","author":"Fisher SP","year":"2009","journal-title":"Neurosci Lett"},{"key":"b50-jpn-39-6\/b50-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/0269881105053308","volume":"19","author":"Ohlsen RI","year":"2005","journal-title":"J Psychopharmacol"},{"key":"b51-jpn-39-6\/b51-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biopha.2005.01.010","volume":"59","author":"Zhu BT","year":"2005","journal-title":"Biomed Pharmacother"},{"key":"b52-jpn-39-6\/b52-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/jm200221q","volume":"54","author":"Koike T","year":"2011","journal-title":"J Med Chem"},{"key":"b53-jpn-39-6\/b53-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1016\/j.bmcl.2010.02.084","volume":"20","author":"Hu Y","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"b54-jpn-39-6\/b54-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/092986713804806649","volume":"20","author":"Chan KH","year":"2013","journal-title":"Curr Med Chem"},{"key":"b55-jpn-39-6\/b55-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.ejmech.2011.02.044","volume":"46","author":"M\u00e9sangeau C","year":"2011","journal-title":"Eur J Med Chem"},{"key":"b56-jpn-39-6\/b56-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuron.2004.08.031","volume":"44","author":"Walker MP","year":"2004","journal-title":"Neuron"},{"issue":"1","key":"b57-jpn-39-6\/b57-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15622971003637637","volume":"11","author":"Born J","year":"2010","journal-title":"World J Biol Psychiatry"},{"key":"b58-jpn-39-6\/b58-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nature05278","volume":"444","author":"Marshall L","year":"2006","journal-title":"Nature"},{"key":"b59-jpn-39-6\/b59-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nature04286","volume":"437","author":"Stickgold R","year":"2005","journal-title":"Nature"},{"key":"b60-jpn-39-6\/b60-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1152\/jappl.1991.70.6.2597","volume":"70","author":"Madsen PL","year":"1991","journal-title":"J Appl Physiol"},{"key":"b61-jpn-39-6\/b61-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-8993(92)90522-B","volume":"571","author":"Maquet P","year":"1992","journal-title":"Brain Res"},{"key":"b62-jpn-39-6\/b62-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1073\/pnas.0706446105","volume":"105","author":"Tasali E","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b63-jpn-39-6\/b63-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1152\/ajpregu.00368.2009","volume":"298","author":"Sayk F","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"b64-jpn-39-6\/b64-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4088\/JCP.v59n1002","volume":"59","author":"Thase ME","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"b65-jpn-39-6\/b65-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1476-5381.1982.tb09194.x","volume":"76","author":"Holmes SW","year":"1982","journal-title":"Br J Pharmacol"},{"key":"b66-jpn-39-6\/b66-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0006-8993(80)90793-3","volume":"201","author":"Mendelson WB","year":"1980","journal-title":"Brain Res"},{"key":"b67-jpn-39-6\/b67-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0006-8993(74)90480-6","volume":"81","author":"Mouret J","year":"1974","journal-title":"Brain Res"},{"key":"b68-jpn-39-6\/b68-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s002130100769","volume":"156","author":"Mailliet F","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"b69-jpn-39-6\/b69-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0091-3057(02)01045-6","volume":"74","author":"Wang F","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"b70-jpn-39-6\/b70-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2004.08.035","volume":"1027","author":"Yukuhiro N","year":"2004","journal-title":"Brain Res"},{"key":"b71-jpn-39-6\/b71-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-079X.1994.tb00078.x","volume":"16","author":"Tobler I","year":"1994","journal-title":"J Pineal Res"},{"key":"b72-jpn-39-6\/b72-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/sleep\/27.7.1319","volume":"27","author":"Miyamoto M","year":"2004","journal-title":"Sleep"},{"key":"b73-jpn-39-6\/b73-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.smrv.2004.04.003","volume":"9","author":"Zhdanova IV","year":"2005","journal-title":"Sleep Med Rev"},{"key":"b74-jpn-39-6\/b74-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0009-9236(95)90040-3","volume":"57","author":"Zhdanova IV","year":"1995","journal-title":"Clin Pharmacol Ther"},{"key":"b75-jpn-39-6\/b75-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/YIC.0b013e32832e9b08","volume":"24","author":"Luthringer R","year":"2009","journal-title":"Int Clin Psychopharmacol"},{"key":"b76-jpn-39-6\/b76-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.smrv.2004.06.004","volume":"9","author":"Brzezinski A","year":"2005","journal-title":"Sleep Med Rev"},{"key":"b77-jpn-39-6\/b77-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-3940(96)12899-8","volume":"214","author":"Nave R","year":"1996","journal-title":"Neurosci Lett"},{"key":"b78-jpn-39-6\/b78-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0893-133X(87)90008-X","volume":"1","author":"James SP","year":"1987","journal-title":"Neuropsychopharmacology"},{"key":"b79-jpn-39-6\/b79-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/sleep\/26.7.893","volume":"26","author":"Singer C","year":"2003","journal-title":"Sleep"},{"key":"b80-jpn-39-6\/b80-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/074873049701200621","volume":"12","author":"Mendelson WB","year":"1997","journal-title":"J Biol Rhythms"},{"key":"b81-jpn-39-6\/b81-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.sleep.2004.07.009","volume":"5","author":"Turek FW","year":"2004","journal-title":"Sleep Med"},{"key":"b82-jpn-39-6\/b82-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/sleep\/17.7.638","volume":"17","author":"Tzischinsky O","year":"1994","journal-title":"Sleep"},{"key":"b83-jpn-39-6\/b83-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2165\/00023210-200519120-00007","volume":"19","author":"McGechan A","year":"2005","journal-title":"CNS Drugs"},{"key":"b84-jpn-39-6\/b84-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/cmdc.200900240","volume":"4","author":"Rivara S","year":"2009","journal-title":"ChemMedChem"},{"key":"b85-jpn-39-6\/b85-jpn-39-6_1","volume-title":"Electroencephalography: basic principles, clinical applications, and related fields","author":"Steriade M","year":"1993"},{"key":"b86-jpn-39-6\/b86-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0006-8993(80)90925-7","volume":"200","author":"Houser CR","year":"1980","journal-title":"Brain Res"},{"key":"b87-jpn-39-6\/b87-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1113\/jphysiol.1993.sp019794","volume":"468","author":"Bal T","year":"1993","journal-title":"J Physiol"},{"key":"b88-jpn-39-6\/b88-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1152\/jn.1985.54.6.1473","volume":"54","author":"Steriade M","year":"1985","journal-title":"J Neurophysiol"},{"key":"b89-jpn-39-6\/b89-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1523\/JNEUROSCI.11-10-03200.1991","volume":"11","author":"Steriade M","year":"1991","journal-title":"J Neurosci"},{"key":"b90-jpn-39-6\/b90-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0306-4522(92)90339-4","volume":"48","author":"Nu\u00f1ez A","year":"1992","journal-title":"Neuroscience"},{"key":"b91-jpn-39-6\/b91-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tins.2005.03.007","volume":"28","author":"Steriade M","year":"2005","journal-title":"Trends Neurosci"},{"key":"b92-jpn-39-6\/b92-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0166-2236(99)01407-1","volume":"22","author":"Steriade M","year":"1999","journal-title":"Trends Neurosci"},{"key":"b93-jpn-39-6\/b93-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1152\/jn.00166.2006","volume":"95","author":"Llin\u00e1s RR","year":"2006","journal-title":"J Neurophysiol"},{"key":"b94-jpn-39-6\/b94-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1096\/fasebj.12.12.1211","volume":"12","author":"Dubocovich ML","year":"1998","journal-title":"FASEB J"},{"key":"b95-jpn-39-6\/b95-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/sleep\/33.3.297","volume":"33","author":"Diniz Behn CG","year":"2010","journal-title":"Sleep"},{"key":"b96-jpn-39-6\/b96-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.smrv.2010.06.004","volume":"15","author":"Thakkar MM","year":"2011","journal-title":"Sleep Med Rev"},{"key":"b97-jpn-39-6\/b97-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/sleep\/33.4.427","volume":"33","author":"Romanowski CPN","year":"2010","journal-title":"Sleep"},{"key":"b98-jpn-39-6\/b98-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1523\/JNEUROSCI.4936-09.2010","volume":"30","author":"Qu WM","year":"2010","journal-title":"J Neurosci"},{"key":"b99-jpn-39-6\/b99-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.smrv.2009.10.003","volume":"14","author":"Monti JM","year":"2010","journal-title":"Sleep Med Rev"},{"key":"b100-jpn-39-6\/b100-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1053\/smrv.2002.0252","volume":"7","author":"De Gennaro L","year":"2003","journal-title":"Sleep Med Rev"},{"key":"b101-jpn-39-6\/b101-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2013.01.008","volume":"243","author":"Comai S","year":"2013","journal-title":"Behav Brain Res"},{"key":"b102-jpn-39-6\/b102-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1073\/pnas.0437938100","volume":"100","author":"Sirota A","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b103-jpn-39-6\/b103-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrd1932","volume":"5","author":"Gershell L","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"b104-jpn-39-6\/b104-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.sleep.2005.08.008","volume":"7","author":"Morin CM","year":"2006","journal-title":"Sleep Med"},{"key":"b105-jpn-39-6\/b105-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuroscience.2006.03.028","volume":"141","author":"Wisor JP","year":"2006","journal-title":"Neuroscience"},{"key":"b106-jpn-39-6\/b106-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrd3789","volume":"11","author":"Ockert W","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"b107-jpn-39-6\/b107-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pnpbp.2012.07.003","volume":"39","author":"Ochoa-Sanchez R","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"b108-jpn-39-6\/b108-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1073\/pnas.0306975101","volume":"101","author":"Kopp C","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b109-jpn-39-6\/b109-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuropharm.2004.03.017","volume":"47","author":"van Lier H","year":"2004","journal-title":"Neuropharmacology"},{"key":"b110-jpn-39-6\/b110-jpn-39-6_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Association AP","year":"1994","edition":"4"},{"key":"b111-jpn-39-6\/b111-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-2999(93)90273-K","volume":"237","author":"Golombek DA","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"b112-jpn-39-6\/b112-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0091-3057(81)90048-4","volume":"15","author":"Golus P","year":"1981","journal-title":"Pharmacol Biochem Behav"},{"key":"b113-jpn-39-6\/b113-jpn-39-6_1","first-page":"9","volume":"17","author":"Papp M","year":"2006","journal-title":"Behav Pharmacol"},{"key":"b114-jpn-39-6\/b114-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1001\/archinte.159.20.2456","volume":"159","author":"Garfinkel D","year":"1999","journal-title":"Arch Intern Med"},{"key":"b115-jpn-39-6\/b115-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(01)01930-9","volume":"307","author":"Nava F","year":"2001","journal-title":"Neurosci Lett"},{"key":"b116-jpn-39-6\/b116-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0091-3057(95)00138-M","volume":"52","author":"Rodgers RJ","year":"1995","journal-title":"Pharmacol Biochem Behav"},{"key":"b117-jpn-39-6\/b117-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2005.09.040","volume":"393","author":"Larson J","year":"2006","journal-title":"Neurosci Lett"},{"key":"b118-jpn-39-6\/b118-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-244X-9-31","volume":"9","author":"Nandi A","year":"2009","journal-title":"BMC Psychiatry"},{"key":"b119-jpn-39-6\/b119-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0166-2236(91)90070-B","volume":"14","author":"Green S","year":"1991","journal-title":"Trends Neurosci"},{"key":"b120-jpn-39-6\/b120-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0006-8993(86)91505-2","volume":"398","author":"Rosenstein RE","year":"1986","journal-title":"Brain Res"},{"key":"b121-jpn-39-6\/b121-jpn-39-6_1","first-page":"301","volume":"7","author":"Lemoine P","year":"2011","journal-title":"Ther Clin Risk Manag"},{"key":"b122-jpn-39-6\/b122-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/nlme.1997.3799","volume":"68","author":"Izquierdo I","year":"1997","journal-title":"Neurobiol Learn Mem"},{"key":"b123-jpn-39-6\/b123-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1067020","volume":"294","author":"Kandel ER","year":"2001","journal-title":"Science"},{"key":"b124-jpn-39-6\/b124-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.neuro.23.1.649","volume":"23","author":"Martin SJ","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"b125-jpn-39-6\/b125-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.conb.2010.06.010","volume":"20","author":"Gerrow K","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"b126-jpn-39-6\/b126-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0166-2236(02)02269-5","volume":"25","author":"Gaiarsa J-L","year":"2002","journal-title":"Trends Neurosci"},{"key":"b127-jpn-39-6\/b127-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1523\/JNEUROSCI.22-21-09626.2002","volume":"22","author":"Abraham WC","year":"2002","journal-title":"J Neurosci"},{"key":"b128-jpn-39-6\/b128-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/brain\/awl082","volume":"129","author":"Cooke SF","year":"2006","journal-title":"Brain"},{"key":"b129-jpn-39-6\/b129-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-079X.2007.00540.x","volume":"44","author":"Bob P","year":"2008","journal-title":"J Pineal Res"},{"key":"b130-jpn-39-6\/b130-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jnr.10605","volume":"72","author":"El-Sherif Y","year":"2003","journal-title":"J Neurosci Res"},{"key":"b131-jpn-39-6\/b131-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","volume":"99","author":"Squire LR","year":"1992","journal-title":"Psychol Rev"},{"key":"b132-jpn-39-6\/b132-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","volume":"11","author":"Deng W","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"b133-jpn-39-6\/b133-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/REVNEURO.2007.18.2.93","volume":"18","author":"Bruel-Jungerman E","year":"2007","journal-title":"Rev Neurosci"},{"key":"b134-jpn-39-6\/b134-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1159\/000125066","volume":"48","author":"Laudon M","year":"1988","journal-title":"Neuroendocrinology"},{"key":"b135-jpn-39-6\/b135-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3940(95)11742-F","volume":"194","author":"Nonno R","year":"1995","journal-title":"Neurosci Lett"},{"key":"b136-jpn-39-6\/b136-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1111\/j.1460-9568.2005.04408.x","volume":"22","author":"Wang LM","year":"2005","journal-title":"Eur J Neurosci"},{"key":"b137-jpn-39-6\/b137-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2010.09.004","volume":"69","author":"Takahashi Y","year":"2011","journal-title":"Neurosci Res"},{"key":"b138-jpn-39-6\/b138-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.lfs.2004.06.009","volume":"75","author":"El-Sherif Y","year":"2004","journal-title":"Life Sci"},{"key":"b139-jpn-39-6\/b139-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"244102","DOI":"10.1088\/0953-8984\/24\/24\/244102","volume":"24","author":"Di Carlo M","year":"2012","journal-title":"J Phys Condens Matter"},{"key":"b140-jpn-39-6\/b140-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-079X.2004.00169.x","volume":"38","author":"Savaskan E","year":"2005","journal-title":"J Pineal Res"},{"key":"b141-jpn-39-6\/b141-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/156720507779939823","volume":"4","author":"Savaskan E","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"b142-jpn-39-6\/b142-jpn-39-6_1","first-page":"311","volume":"50","author":"Brunner P","year":"2006","journal-title":"Eur J Histochem"},{"key":"b143-jpn-39-6\/b143-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neubiorev.2004.09.002","volume":"28","author":"Dudchenko PA","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"b144-jpn-39-6\/b144-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbr.2009.05.022","volume":"203","author":"Paul CM","year":"2009","journal-title":"Behav Brain Res"},{"key":"b145-jpn-39-6\/b145-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0893-133X(99)00145-1","volume":"22","author":"Bunney WE","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"b146-jpn-39-6\/b146-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00001756-199801260-00014","volume":"9","author":"Overstreet DH","year":"1998","journal-title":"Neuroreport"},{"key":"b147-jpn-39-6\/b147-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.euroneuro.2006.01.005","volume":"16","author":"Micale V","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"b148-jpn-39-6\/b148-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2010.04.011","volume":"638","author":"Binfar\u00e9 RW","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"b149-jpn-39-6\/b149-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00008877-199902000-00007","volume":"10","author":"Kopp C","year":"1999","journal-title":"Behav Pharmacol"},{"key":"b150-jpn-39-6\/b150-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-079X.2005.00233.x","volume":"39","author":"Sumaya IC","year":"2005","journal-title":"J Pineal Res"},{"key":"b151-jpn-39-6\/b151-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(11)60095-0","volume":"378","author":"Hickie IB","year":"2011","journal-title":"Lancet"},{"key":"b152-jpn-39-6\/b152-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jpsychires.2012.08.013","volume":"46","author":"Fava M","year":"2012","journal-title":"J Psychiatr Res"},{"key":"b153-jpn-39-6\/b153-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrd3140","volume":"9","author":"de Bodinat C","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"b154-jpn-39-6\/b154-jpn-39-6_1","first-page":"126","volume":"29","author":"Bourin M","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"b155-jpn-39-6\/b155-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.psychres.2011.01.021","volume":"189","author":"Galecka E","year":"2011","journal-title":"Psychiatry Res"},{"key":"b156-jpn-39-6\/b156-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.lfs.2009.01.024","volume":"84","author":"Ambriz-Tututi M","year":"2009","journal-title":"Life Sci"},{"key":"b157-jpn-39-6\/b157-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-079X.2011.00895.x","volume":"51","author":"Wilhelmsen M","year":"2011","journal-title":"J Pineal Res"},{"key":"b158-jpn-39-6\/b158-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","volume":"27","author":"Dubocovich ML","year":"2005","journal-title":"Endocrine"},{"key":"b159-jpn-39-6\/b159-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.lfs.2009.01.024","volume":"84","author":"Ambriz-Tututi M","year":"2009","journal-title":"Life Sci"},{"key":"b160-jpn-39-6\/b160-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000109138","volume":"6","author":"Pang SF","year":"1997","journal-title":"Biol Signals"},{"key":"b161-jpn-39-6\/b161-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.lfs.2008.09.028","volume":"83","author":"Yoon MH","year":"2008","journal-title":"Life Sci"},{"key":"b162-jpn-39-6\/b162-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejphar.2007.09.006","volume":"577","author":"Arreola-Espino R","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"b163-jpn-39-6\/b163-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(00)00883-1","volume":"282","author":"Yu CX","year":"2000","journal-title":"Neurosci Lett"},{"key":"b164-jpn-39-6\/b164-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pain.2007.01.025","volume":"132","author":"Ambriz-Tututi M","year":"2007","journal-title":"Pain"},{"key":"b165-jpn-39-6\/b165-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng.288","volume":"41","author":"Lyssenko V","year":"2009","journal-title":"Nat Genet"},{"key":"b166-jpn-39-6\/b166-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.290","volume":"41","author":"Prokopenko I","year":"2009","journal-title":"Nat Genet"},{"key":"b167-jpn-39-6\/b167-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1464-5491.2011.03374.x","volume":"28","author":"Dietrich K","year":"2011","journal-title":"Diabet Med"},{"key":"b168-jpn-39-6\/b168-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000329306","volume":"4","author":"Song JY","year":"2011","journal-title":"Obes Facts"},{"key":"b169-jpn-39-6\/b169-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF03401539","volume":"11","author":"Vlassi M","year":"2012","journal-title":"Hormones"},{"key":"b170-jpn-39-6\/b170-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/EJE-10-0588","volume":"164","author":"Holzapfel C","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"b171-jpn-39-6\/b171-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng.277","volume":"41","author":"Bouatia-Naji N","year":"2009","journal-title":"Nat Genet"},{"key":"b172-jpn-39-6\/b172-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.2337\/db08-1805","volume":"58","author":"Chambers JC","year":"2009","journal-title":"Diabetes"},{"key":"b173-jpn-39-6\/b173-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ng.1053","volume":"44","author":"Bonnefond A","year":"2012","journal-title":"Nat Genet"},{"key":"b174-jpn-39-6\/b174-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"e3962","DOI":"10.1371\/journal.pone.0003962","volume":"3","author":"Staiger H","year":"2008","journal-title":"PLoS ONE"},{"key":"b175-jpn-39-6\/b175-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"Wild S","year":"2004","journal-title":"Diabetes Care"},{"key":"b176-jpn-39-6\/b176-jpn-39-6_1","first-page":"BR61","volume":"16","author":"Adi N","year":"2010","journal-title":"Med Sci Monit"},{"key":"b177-jpn-39-6\/b177-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1097\/BRS.0b013e3180b9f0ff","volume":"32","author":"Qiu XS","year":"2007","journal-title":"Spine"},{"key":"b178-jpn-39-6\/b178-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-079X.2005.00237.x","volume":"39","author":"Ha E","year":"2005","journal-title":"J Pineal Res"},{"key":"b179-jpn-39-6\/b179-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000054684","volume":"74","author":"Drazen DL","year":"2001","journal-title":"Neuroendocrinology"},{"key":"b180-jpn-39-6\/b180-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1034\/j.1600-079X.2003.00051.x","volume":"35","author":"Ekmekcioglu C","year":"2003","journal-title":"J Pineal Res"},{"key":"b181-jpn-39-6\/b181-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1002\/jnr.22430","volume":"88","author":"Lee CH","year":"2010","journal-title":"J Neurosci Res"},{"key":"b182-jpn-39-6\/b182-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1161\/hc4201.097834","volume":"104","author":"Carney RM","year":"2001","journal-title":"Circulation"},{"key":"b183-jpn-39-6\/b183-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0022-3999(02)00302-1","volume":"53","author":"Eaton WW","year":"2002","journal-title":"J Psychosom Res"},{"key":"b184-jpn-39-6\/b184-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/sleep\/30.2.213","volume":"30","author":"Taylor DJ","year":"2007","journal-title":"Sleep"},{"key":"b185-jpn-39-6\/b185-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","volume":"5","author":"Biessels GJ","year":"2006","journal-title":"Lancet Neurol"},{"key":"b186-jpn-39-6\/b186-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1210\/jc.2009-2430","volume":"95","author":"Donga E","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"b187-jpn-39-6\/b187-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/sleep\/30.12.1667","volume":"30","author":"Gangwisch JE","year":"2007","journal-title":"Sleep"},{"key":"b188-jpn-39-6\/b188-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archinte.165.8.863","volume":"165","author":"Gottlieb DJ","year":"2005","journal-title":"Arch Intern Med"},{"key":"b189-jpn-39-6\/b189-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2337\/diacare.29.03.06.dc05-0879","volume":"29","author":"Yaggi HK","year":"2006","journal-title":"Diabetes Care"},{"key":"b190-jpn-39-6\/b190-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00125-011-2106-8","volume":"54","author":"Olsson L","year":"2011","journal-title":"Diabetologia"},{"key":"b191-jpn-39-6\/b191-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"Lawrence RC","year":"2008","journal-title":"Arthritis Rheum"},{"key":"b192-jpn-39-6\/b192-jpn-39-6_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0165-6147(97)90676-3","volume":"18","author":"Stadel JM","year":"1997","journal-title":"Trends Pharmacol Sci"},{"key":"b193-jpn-39-6\/b193-jpn-39-6_1","volume-title":"Stereotaxic coordinates","author":"Paxinos G","year":"2006"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.130009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.130009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:38:01Z","timestamp":1756831081000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.130009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":193,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1503\/jpn.130009"],"URL":"https:\/\/doi.org\/10.1503\/jpn.130009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725273977.793502230","asserted-by":"object"}]},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}