{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:46:25Z","timestamp":1790444785670,"version":"4.1.0"},"reference-count":60,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Previous resting-state functional connectivity studies in patients with anorexia nervosa used independent component analysis or seed-based connectivity analysis to probe specific brain networks. Instead, modelling the entire brain as a complex network allows determination of graph-theoretical metrics, which describe global and local properties of how brain networks are organized and how they interact. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> To determine differences in network properties between female patients with acute anorexia nervosa and pairwise matched healthy controls, we used resting-state fMRI and computed well-established global and local graph metrics across a range of network densities. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Our analyses included 35 patients and 35 controls. We found that the global functional network structure in patients with anorexia nervosa is characterized by increases in both characteristic path length (longer average routes between nodes) and assortativity (more nodes with a similar connectedness link together). Accordingly, we found locally decreased connectivity strength and increased path length in the posterior insula and thalamus. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> The present results may be limited to the methods applied during preprocessing and network construction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> We demonstrated anorexia nervosa\u2013related changes in the network configuration for, to our knowledge, the first time using resting-state fMRI and graph-theoretical measures. Our findings revealed an altered global brain network architecture accompanied by local degradations indicating wide-scale disturbance in information flow across brain networks in patients with acute anorexia nervosa. Reduced local network efficiency in the thalamus and posterior insula may reflect a mechanism that helps explain the impaired integration of visuospatial and homeostatic signals in patients with this disorder, which is thought to be linked to abnormal representations of body size and hunger. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.140310","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T09:42:16Z","timestamp":1450258936000},"page":"6-15","source":"Crossref","is-referenced-by-count":55,"title":["Abnormal functional global and local brain connectivity in female patients with anorexia nervosa"],"prefix":"10.1139","volume":"41","author":[{"given":"Daniel","family":"Geisler","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universit\u00e4t Dresden, Faculty of Medicine, University Hospital C. G. 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