{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T17:10:15Z","timestamp":1756833015828,"version":"3.44.0"},"reference-count":51,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> We conducted a genome-wide gene \u00d7 environment interaction analysis to identify genetic variants that interact with cannabis dependence (CaD) in influencing risky sexual behaviours (RSB). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Our sample included cannabis-exposed and sexually experienced African-American and European-American participants. A DSM-IV CaD diagnosis and RSB were evaluated using the Semi-Structured Assessment for Drug Dependence and Alcoholism. We analyzed RSBs as a score that takes into account experiences of unprotected sex and multiple sexual partners. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 3350 people participated in our study; 43% had a CaD diagnosis, 56% were African-American and 33% were women. We identified a genome-wide significant locus in African-American participants ( S100A10 rs72993629, p = 2.73 \u00d7 10<jats:sup>\u22128<\/jats:sup>) and a potential transpopulation signal in women ( CLTC rs12944716, p = 5.27 \u00d7 10<jats:sup>\u22128<\/jats:sup>). A resting-state fMRI follow-up analysis of S100A10 rs72993629 conducted in an independent cohort showed 2 significant associations: reduced power of the left paracentral lobule in amplitude of low frequency fluctuations (ALFF) analysis ( p = 7.8 \u00d7 10<jats:sup>\u22123<\/jats:sup>) and reduced power of the right pallidum in fractional ALFF analysis ( p = 4.6 \u00d7 10<jats:sup>\u22123<\/jats:sup>). The activity of these brain regions is known to be involved in sexual functions and behaviours. The S100A10 result functionally recapitulated our S100B finding observed in our previous genome-wide association study of CaD. The probability of identifying 2 S100 genes in 2 independent genome-wide investigations by chance is approximately 1 in 1.1 million. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> We were not able to identify any African-American cohort with appropriate sample size, and phenotypic assessment is available to replicate our findings. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The S100A10 and S100B genes, which are located on different chromosomes, encode specialized calcium-binding proteins. These data support a role for calcium homeostasis in individuals with CaD and its induced behaviours. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.160189","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T19:32:37Z","timestamp":1498073557000},"page":"252-261","source":"Crossref","is-referenced-by-count":9,"title":["<i>S100A10<\/i> identified in a genome-wide gene \u00d7 cannabis dependence interaction analysis of risky sexual behaviours"],"prefix":"10.1139","volume":"42","author":[{"given":"Renato","family":"Polimanti","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Conn., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashwath A.","family":"Meda","sequence":"additional","affiliation":[{"name":"Olin Research Center, Institute of Living\/Hartford Hospital, Hartford, Conn., 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