{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:37:53Z","timestamp":1791815873824,"version":"4.3.4"},"reference-count":41,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> In the last decade, many studies have reported abnormal connectivity within the default mode network (DMN) in patients with Alzheimer disease. Few studies, however, have investigated other networks and their association with pathophysiological proteins obtained from cerebrospinal fluid (CSF). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We performed 3 T imaging in patients with mild Alzheimer disease, patients with amnestic mild cognitive impairment (aMCI) and healthy controls, and we collected CSF samples from the patients with aMCI and mild Alzheimer disease. We analyzed 57 regions from 8 networks. Additionally, we performed correlation tests to investigate possible associations between the networks\u2019 functional connectivity and the protein levels obtained from the CSF of patients with aMCI and Alzheimer disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Our sample included 41 patients with Alzheimer disease, 35 with aMCI and 48 controls. We found that the main connectivity abnormalities in those with Alzheimer disease occurred between the DMN and task-positive networks: these patients presented not only a decreased anticorrelation between some regions, but also an inversion of the correlation signal (positive correlation instead of anti-correlation). Those with aMCI did not present statistically different connectivity from patients with Alzheimer disease or controls. Abnormal levels of CSF proteins were associated with functional disconnectivity between several regions in both the aMCI and mild Alzheimer disease groups, extending well beyond the DMN or temporal areas. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> The presented data are cross-sectional in nature, and our findings are dependent on the choice of seed regions used. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> We found that the main functional connectivity abnormalities occur between the DMN and task-positive networks and that the pathological levels of CSF biomarkers correlate with functional connectivity disruption in patients with Alzheimer disease. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.160190","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T09:39:42Z","timestamp":1509356382000},"page":"366-377","source":"Crossref","is-referenced-by-count":28,"title":["Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels"],"prefix":"10.1139","volume":"42","author":[{"given":"Marina","family":"Weiler","sequence":"first","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunno Machado","family":"de Campos","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Vieira","family":"de Ligo Teixeira","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Fernandes","family":"Casseb","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"Mac Knight Carletti-Cassani","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Elias","family":"Vicentini","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamires Naela Cardoso","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda Leme","family":"Talib","sequence":"additional","affiliation":[{"name":"and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes Vicente","family":"Forlenza","sequence":"additional","affiliation":[{"name":"and the Laboratory of Neuroscience, Department & Institute of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Luiz Figueredo","family":"Balthazar","sequence":"additional","affiliation":[{"name":"From the Neuroimaging Laboratory, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-42-6-366\/b1-42-6-366_1","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1002\/hbm.22414","volume":"35","author":"He X","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"b2-42-6-366\/b2-42-6-366_1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2011.06.007","volume":"33","author":"Agosta F","year":"2012","journal-title":"Neurobiol Aging"},{"key":"b3-42-6-366\/b3-42-6-366_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/1567205011666140131114716","volume":"11","author":"Weiler M","year":"2014","journal-title":"Curr Alzheimer Res"},{"key":"b4-42-6-366\/b4-42-6-366_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/WCO.0b013e32835a26b3","volume":"25","author":"Greicius MD","year":"2012","journal-title":"Curr Opin Neurol"},{"key":"b5-42-6-366\/b5-42-6-366_1","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1093\/cercor\/bhu246","volume":"25","author":"Dai Z","year":"2015","journal-title":"Cereb Cortex"},{"key":"b6-42-6-366\/b6-42-6-366_1","doi-asserted-by":"crossref","first-page":"e63727","DOI":"10.1371\/journal.pone.0063727","volume":"8","author":"Song J","year":"2013","journal-title":"PLoS One"},{"key":"b7-42-6-366\/b7-42-6-366_1","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1038\/srep14824","volume":"5","author":"Wang P","year":"2015","journal-title":"Sci Rep"},{"key":"b8-42-6-366\/b8-42-6-366_1","unstructured":"BrierMRThomasJBSnyderAZ.Loss of intranetwork and internetwork resting state functional connections with Alzheimer\u2019s disease progression"},{"key":"b9-42-6-366\/b9-42-6-366_1","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","volume":"25","author":"Buckner RL","year":"2005","journal-title":"J Neurosci"},{"key":"b10-42-6-366\/b10-42-6-366_1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","volume":"67","author":"Sheline YI","year":"2010","journal-title":"Biol Psychiatry"},{"key":"b11-42-6-366\/b11-42-6-366_1","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1001\/jama.2011.810","volume":"305","author":"McKhann GM","year":"2011","journal-title":"JAMA"},{"key":"b12-42-6-366\/b12-42-6-366_1","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","volume":"43","author":"Morris JC","year":"1993","journal-title":"Neurology"},{"key":"b13-42-6-366\/b13-42-6-366_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"Albert MS","year":"2011","journal-title":"Alzheimers Dement"},{"key":"b14-42-6-366\/b14-42-6-366_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1212\/01.wnl.0000256697.20968.d7","volume":"68","author":"Devanand DP","year":"2007","journal-title":"Neurology"},{"key":"b15-42-6-366\/b15-42-6-366_1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archneur.1975.00490510088009","volume":"32","author":"Hachinski VC","year":"1975","journal-title":"Arch Neurol"},{"key":"b16-42-6-366\/b16-42-6-366_1","first-page":"351","volume":"149","author":"Fazekas F","year":"1987","journal-title":"AJNR Am J Neuroradiol"},{"key":"b17-42-6-366\/b17-42-6-366_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1373\/clinchem.2004.039347","volume":"51","author":"Olsson A","year":"2005","journal-title":"Clin Chem"},{"key":"b18-42-6-366\/b18-42-6-366_1","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/hbm.23231","volume":"37","author":"De Campos BM","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"b19-42-6-366\/b19-42-6-366_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroimage.2011.07.044","volume":"59","author":"Van Dijk KR","year":"2012","journal-title":"Neuroimage"},{"key":"b20-42-6-366\/b20-42-6-366_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cercor\/bhr099","volume":"22","author":"Shirer WR","year":"2012","journal-title":"Cereb Cortex"},{"key":"b21-42-6-366\/b21-42-6-366_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3233\/JAD-2009-1177","volume":"18","author":"Blennow K","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"b22-42-6-366\/b22-42-6-366_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneurol.2008.596","volume":"66","author":"Tapiola T","year":"2009","journal-title":"Arch Neurol"},{"key":"b23-42-6-366\/b23-42-6-366_1","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.7717\/peerj.367","volume":"2","author":"Di X","year":"2014","journal-title":"PeerJ"},{"key":"b24-42-6-366\/b24-42-6-366_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/JAD-141824","volume":"44","author":"Bozzali M","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"b25-42-6-366\/b25-42-6-366_1","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.0504136102","volume":"102","author":"Fox MD","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b26-42-6-366\/b26-42-6-366_1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.tics.2012.10.008","volume":"16","author":"Anticevic A","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"b27-42-6-366\/b27-42-6-366_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuroimage.2007.03.071","volume":"37","author":"Cole MW","year":"2007","journal-title":"Neuroimage"},{"key":"b28-42-6-366\/b28-42-6-366_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3233\/JAD-2010-101038","volume":"22","author":"Sala-Llonch R","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"b29-42-6-366\/b29-42-6-366_1","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1002\/hbm.22489","volume":"35","author":"Hansen NL","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"b30-42-6-366\/b30-42-6-366_1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.neuroimage.2011.08.009","volume":"59","author":"Liang Z","year":"2012","journal-title":"Neuroimage"},{"key":"b31-42-6-366\/b31-42-6-366_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nbd.2015.08.005","volume":"90","author":"Kann O","year":"2016","journal-title":"Neurobiol Dis"},{"key":"b32-42-6-366\/b32-42-6-366_1","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/brain\/awu271","volume":"137","author":"Lim HK","year":"2014","journal-title":"Brain"},{"key":"b33-42-6-366\/b33-42-6-366_1","first-page":"695","volume":"26","author":"Elman JA","year":"2016","journal-title":"Cereb Cortex"},{"key":"b34-42-6-366\/b34-42-6-366_1","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/brain\/awt146","volume":"136","author":"Sepulcre J","year":"2013","journal-title":"Brain"},{"key":"b35-42-6-366\/b35-42-6-366_1","first-page":"3137","volume":"37","author":"Myers N","year":"2014","journal-title":"Brain"},{"key":"b36-42-6-366\/b36-42-6-366_1","author":"Koch K","year":"2015","journal-title":"Cereb Cortex"},{"key":"b37-42-6-366\/b37-42-6-366_1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/srep01339","volume":"3","author":"Li X","year":"2013","journal-title":"Sci Rep"},{"key":"b38-42-6-366\/b38-42-6-366_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1034\/j.1600-0404.107.s179.9.x","volume":"179","author":"Andreasen N","year":"2003","journal-title":"Acta Neurol Scand Suppl"},{"key":"b39-42-6-366\/b39-42-6-366_1","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/brain\/awl269","volume":"129","author":"Buerger K","year":"2006","journal-title":"Brain"},{"key":"b40-42-6-366\/b40-42-6-366_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1001\/jamaneurol.2013.1453","volume":"70","author":"Walker LC","year":"2013","journal-title":"JAMA Neurol"},{"key":"b41-42-6-366\/b41-42-6-366_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s11682-012-9177-0","volume":"6","author":"Han SD","year":"2012","journal-title":"Brain Imaging Behav"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.160190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.160190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:31:27Z","timestamp":1756830687000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.160190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1503\/jpn.160190"],"URL":"https:\/\/doi.org\/10.1503\/jpn.160190","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}