{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:54:02Z","timestamp":1792446842029,"version":"4.5.0"},"reference-count":49,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> It is unknown whether impaired coupling among 3 core large-scale brain networks (salience [SN], default mode [DMN] and executive control networks [ECN]) is associated with relapse behaviour in treated heroin-dependent patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We conducted a prospective resting-state functional MRI study comparing the functional connectivity strength among healthy controls and heroin-dependent men who had either relapsed or were in early remission. Men were considered to be either relapsed or in early remission based on urine drug screens during a 3-month follow-up period. We also examined how the coupling of large-scale networks correlated with relapse behaviour among heroin-dependent men. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We included 20 controls and 50 heroin-dependent men (26 relapsed and 24 early remission) in our analyses. The relapsed men showed greater connectivity than the early remission and control groups between the dorsal anterior cingulate cortex (key node of the SN) and the dorsomedial prefrontal cortex (included in the DMN). The relapsed men and controls showed lower connectivity than the early remission group between the left dorsolateral prefrontal cortex (key node of the left ECN) and the dorsomedial prefrontal cortex. The percentage of positive urine drug screens positively correlated with the coupling between the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex, but negatively correlated with the coupling between the left dorsolateral prefrontal cortex and dorsomedial prefrontal cortex. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p> We examined deficits in only 3 core networks leading to relapse behaviour. Other networks may also contribute to relapse. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Greater coupling between the SN and DMN and lower coupling between the left ECN and DMN is associated with relapse behaviour. These findings may shed light on the development of new treatments for heroin addiction. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.170011","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T18:21:25Z","timestamp":1513621285000},"page":"48-57","source":"Crossref","is-referenced-by-count":58,"title":["Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men"],"prefix":"10.1139","volume":"43","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"From the Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"},{"name":"the Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jierong","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Tangdu Hospital, Fourth Military Medical University, 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