{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:06:32Z","timestamp":1769166392435,"version":"3.49.0"},"reference-count":59,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Working-memory impairment is a core cognitive dysfunction in people with schizophrenia and people at mental high risk. Recent imaging studies on working memory have suggested that abnormalities in prefrontal activation and in connectivity between the frontal and parietal regions could be neural underpinnings of the different stages of psychosis. However, it remains to be explored whether comparable alterations are present in people with subclinical levels of psychosis, as experienced by a small proportion of the general population who neither seek help nor show constraints in daily functioning. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We compared 24 people with subclinical high delusional ideation and 24 people with low delusional ideation. Both groups performed an n-back working-memory task during functional magnetic resonance imaging. We characterized frontoparietal effective connectivity using dynamic causal modelling. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Compared to people who had low delusional ideation, people with high delusional ideation showed a significant increase in dorsolateral prefrontal activation during the working-memory task, as well as reduced working-memory-dependent parietofrontal effective connectivity in the left hemisphere. Group differences were not evident at the behavioural level. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> The current experimental design did not distinguish among the working-memory subprocesses; it remains unexplored whether differences in connectivity exist at that level. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> These findings suggest that alterations in the working-memory network are also present in a nonclinical population with psychotic experiences who do not display cognitive deficits. They also suggest that alterations in working-memory-dependent connectivity show a putative continuity along the spectrum of psychotic symptoms. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.180043","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T08:05:08Z","timestamp":1556697908000},"page":"195-204","source":"Crossref","is-referenced-by-count":11,"title":["Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation"],"prefix":"10.1139","volume":"44","author":[{"given":"Yu","family":"Fukuda","sequence":"first","affiliation":[{"name":"From the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Katthagen","sequence":"additional","affiliation":[{"name":"From the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Deserno","sequence":"additional","affiliation":[{"name":"the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany"},{"name":"Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Shayegan","sequence":"additional","affiliation":[{"name":"the Columbia University College of Physicians and Surgeons, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Kaminski","sequence":"additional","affiliation":[{"name":"From the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany"},{"name":"Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"the Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[{"name":"From the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"From the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany"},{"name":"Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"b1-44-3-195\/b1-44-3-195_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hbm.20131","volume":"25","author":"Owen AM","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"b2-44-3-195\/b2-44-3-195_1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1152\/jn.2000.83.3.1550","volume":"83","author":"Chafee MV","year":"2000","journal-title":"J Neurophysiol"},{"key":"b3-44-3-195\/b3-44-3-195_1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0006-3223(98)00318-7","volume":"45","author":"Manoach DS","year":"1999","journal-title":"Biol Psychiatry"},{"key":"b4-44-3-195\/b4-44-3-195_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0920-9964(02)00294-3","volume":"60","author":"Manoach D","year":"2003","journal-title":"Schizophr Res"},{"key":"b5-44-3-195\/b5-44-3-195_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-3223(02)01675-X","volume":"53","author":"Perlstein WM","year":"2003","journal-title":"Biol Psychiatry"},{"key":"b6-44-3-195\/b6-44-3-195_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1523\/JNEUROSCI.3405-11.2012","volume":"32","author":"Deserno L","year":"2012","journal-title":"J Neurosci"},{"key":"b7-44-3-195\/b7-44-3-195_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jamapsychiatry.2013.117","volume":"70","author":"Schmidt A","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"b8-44-3-195\/b8-44-3-195_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1503\/jpn.130102","volume":"39","author":"Schmidt A","year":"2014","journal-title":"J Psychiatry Neurosci"},{"key":"b9-44-3-195\/b9-44-3-195_1","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1093\/cercor\/bhx050","volume":"27","author":"Nielsen JD","year":"2017","journal-title":"Cereb Cortex"},{"key":"b10-44-3-195\/b10-44-3-195_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0033291708003814","volume":"39","author":"van Os J","year":"2009","journal-title":"Psychol Med"},{"key":"b11-44-3-195\/b11-44-3-195_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0272-7358(01)00103-9","volume":"21","author":"Johns LC","year":"2001","journal-title":"Clin Psychol Rev"},{"key":"b12-44-3-195\/b12-44-3-195_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1017\/S0033291712001626","volume":"43","author":"Linscott RJ","year":"2013","journal-title":"Psychol Med"},{"key":"b13-44-3-195\/b13-44-3-195_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1017\/S0033291708004558","volume":"39","author":"Forbes NF","year":"2009","journal-title":"Psychol Med"},{"key":"b14-44-3-195\/b14-44-3-195_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0920-9964(99)00121-8","volume":"42","author":"Lenzenweger MF","year":"2000","journal-title":"Schizophr Res"},{"key":"b15-44-3-195\/b15-44-3-195_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0165-1781(02)00099-9","volume":"110","author":"Spitznagel MB","year":"2002","journal-title":"Psychiatry Res"},{"key":"b16-44-3-195\/b16-44-3-195_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.schres.2006.06.041","volume":"88","author":"Keefe RS","year":"2006","journal-title":"Schizophr Res"},{"key":"b17-44-3-195\/b17-44-3-195_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.eurpsy.2010.07.008","volume":"27","author":"Broome MR","year":"2012","journal-title":"Eur Psychiatry"},{"key":"b18-44-3-195\/b18-44-3-195_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/oxfordjournals.schbul.a033401","volume":"25","author":"Peters ER","year":"1999","journal-title":"Schizophr Bull"},{"key":"b19-44-3-195\/b19-44-3-195_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpsychires.2016.08.001","volume":"83","author":"McTeague LM","year":"2016","journal-title":"J Psychiatr Res"},{"key":"b20-44-3-195\/b20-44-3-195_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/archgenpsychiatry.2009.91","volume":"66","author":"Minzenberg MJ","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"b21-44-3-195\/b21-44-3-195_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cercor\/9.1.20","volume":"9","author":"Callicott JH","year":"1999","journal-title":"Cereb Cortex"},{"key":"b22-44-3-195\/b22-44-3-195_1","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1176\/appi.ajp.160.12.2209","volume":"160","author":"Callicott JH","year":"2003","journal-title":"Am J Psychiatry"},{"key":"b23-44-3-195\/b23-44-3-195_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2016.02.023","volume":"173","author":"Thermenos HW","year":"2016","journal-title":"Schizophr Res"},{"key":"b24-44-3-195\/b24-44-3-195_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1176\/appi.ajp.2013.12081135","volume":"170","author":"Yaakub SN","year":"2013","journal-title":"Am J Psychiatry"},{"key":"b25-44-3-195\/b25-44-3-195_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2016.07.014","volume":"176","author":"Friston K","year":"2016","journal-title":"Schizophr Res"},{"key":"b26-44-3-195\/b26-44-3-195_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.biopsych.2017.01.004","volume":"81","author":"Krystal JH","year":"2017","journal-title":"Biol Psychiatry"},{"key":"b27-44-3-195\/b27-44-3-195_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1176\/jnp.5.3.241","volume":"5","author":"Weinberger DR","year":"1993","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"b28-44-3-195\/b28-44-3-195_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.biopsych.2005.10.005","volume":"59","author":"Stephan KE","year":"2006","journal-title":"Biol Psychiatry"},{"key":"b29-44-3-195\/b29-44-3-195_1","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1093\/cercor\/bhv181","volume":"25","author":"Fonville L","year":"2015","journal-title":"Cereb Cortex"},{"key":"b30-44-3-195\/b30-44-3-195_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/oxfordjournals.schbul.a007116","volume":"30","author":"Peters E","year":"2004","journal-title":"Schizophr Bull"},{"key":"b31-44-3-195\/b31-44-3-195_1","volume-title":"Structured clinical interview for DSM-IV axis I disorders","author":"First M","year":"1997"},{"key":"b32-44-3-195\/b32-44-3-195_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","volume":"9","author":"Oldfield RC","year":"1971","journal-title":"Neuropsychologia"},{"key":"b33-44-3-195\/b33-44-3-195_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/schbul\/17.4.555","volume":"17","author":"Raine A","year":"1991","journal-title":"Schizophr Bull"},{"key":"b34-44-3-195\/b34-44-3-195_1","volume-title":"WST-Wortschatztest","author":"Schmidt K-HMP","year":"1992"},{"key":"b35-44-3-195\/b35-44-3-195_1","doi-asserted-by":"crossref","first-page":"10103","DOI":"10.1523\/JNEUROSCI.0805-15.2015","volume":"35","author":"Boehme R","year":"2015","journal-title":"J Neurosci"},{"key":"b36-44-3-195\/b36-44-3-195_1","first-page":"67","volume":"42","author":"Pankow A","year":"2016","journal-title":"Schizophr Bull"},{"key":"b37-44-3-195\/b37-44-3-195_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.euroneuro.2008.04.013","volume":"18","author":"Schlagenhauf F","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"b38-44-3-195\/b38-44-3-195_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","volume":"2","author":"Friston KJ","year":"1994","journal-title":"Hum Brain Mapp"},{"key":"b39-44-3-195\/b39-44-3-195_1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1523\/JNEUROSCI.2463-13.2014","volume":"34","author":"Heinzel S","year":"2014","journal-title":"J Neurosci"},{"key":"b40-44-3-195\/b40-44-3-195_1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.10.026","volume":"34","author":"Kiebel SJ","year":"2007","journal-title":"Neuroimage"},{"key":"b41-44-3-195\/b41-44-3-195_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuroimage.2009.03.025","volume":"46","author":"Stephan KE","year":"2009","journal-title":"Neuroimage"},{"key":"b42-44-3-195\/b42-44-3-195_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuroimage.2013.08.065","volume":"84","author":"Rigoux L","year":"2014","journal-title":"Neuroimage"},{"key":"b43-44-3-195\/b43-44-3-195_1","doi-asserted-by":"crossref","first-page":"e1000709","DOI":"10.1371\/journal.pcbi.1000709","volume":"6","author":"Penny WD","year":"2010","journal-title":"PLOS Comput Biol"},{"key":"b44-44-3-195\/b44-44-3-195_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/schbul\/sbr038","volume":"38","author":"Choi JS","year":"2012","journal-title":"Schizophr Bull"},{"key":"b45-44-3-195\/b45-44-3-195_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/schbul\/sbn162","volume":"35","author":"Potkin SG","year":"2009","journal-title":"Schizophr Bull"},{"key":"b46-44-3-195\/b46-44-3-195_1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1006\/nimg.2002.1280","volume":"17","author":"Cabeza R","year":"2002","journal-title":"Neuroimage"},{"key":"b47-44-3-195\/b47-44-3-195_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/adb.12103","volume":"19","author":"Charlet K","year":"2014","journal-title":"Addict Biol"},{"key":"b48-44-3-195\/b48-44-3-195_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.biopsych.2007.06.017","volume":"63","author":"Karlsgodt KH","year":"2008","journal-title":"Biol Psychiatry"},{"key":"b49-44-3-195\/b49-44-3-195_1","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/hbm.21329","volume":"33","author":"Ma L","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"b50-44-3-195\/b50-44-3-195_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0896-6273(03)00036-9","volume":"37","author":"Eger E","year":"2003","journal-title":"Neuron"},{"key":"b51-44-3-195\/b51-44-3-195_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.schres.2015.08.024","volume":"168","author":"Hager OM","year":"2015","journal-title":"Schizophr Res"},{"key":"b52-44-3-195\/b52-44-3-195_1","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1002\/hbm.22382","volume":"35","author":"Dima D","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"b53-44-3-195\/b53-44-3-195_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1098\/rstb.2007.2086","volume":"362","author":"D\u2019Esposito M","year":"2007","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"b54-44-3-195\/b54-44-3-195_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3389\/fnhum.2014.00633","volume":"8","author":"Schmidt A","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"b55-44-3-195\/b55-44-3-195_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neubiorev.2006.11.006","volume":"31","author":"Fusar-Poli P","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"key":"b56-44-3-195\/b56-44-3-195_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4088\/JCP.09m05797yel","volume":"72","author":"Daalman K","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"b57-44-3-195\/b57-44-3-195_1","first-page":"3","volume":"10","author":"Lee KW","year":"2016","journal-title":"Early Interv Psychiatry"},{"key":"b58-44-3-195\/b58-44-3-195_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1741-7015-11-126","volume":"11","author":"Cuthbert BN","year":"2013","journal-title":"BMC Med"},{"key":"b59-44-3-195\/b59-44-3-195_1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1176\/appi.ajp.162.10.1849","volume":"162","author":"Tan H-Y","year":"2005","journal-title":"Am J Psychiatry"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.180043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.180043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:42:41Z","timestamp":1756831361000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.180043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1503\/jpn.180043"],"URL":"https:\/\/doi.org\/10.1503\/jpn.180043","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}