{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:37Z","timestamp":1790507797714,"version":"4.1.0"},"reference-count":63,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Cortical folding is essential for healthy brain development. Previous studies have found regional reductions in cortical folding in adult patients with psychotic illness. It is unknown whether these neuroanatomical markers are present in youth with subclinical psychotic symptoms. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We collected MRIs and examined the local gyrification index in a sample of 110 youth (mean age \u00b1 standard deviation 14.0 \u00b1 3.7 yr; range 9\u201325 yr) with a family history of severe mental illness: 48 with psychotic symptoms and 62 without. Images were processed using the Human Connectome Pipeline and FreeSurfer. We tested for group differences in local gyrification index using mixed-effects generalized linear models controlling for age, sex and familial clustering. Sensitivity analysis further controlled for intracranial volume, IQ, and stimulant and cannabis use. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Youth with psychotic symptoms displayed an overall trend toward lower cortical folding across all brain regions. After adjusting for multiple comparisons and confounders, regional reductions were localized to the frontal and occipital lobes. Specifically, the medial ( B = \u22120.42, p <jats:sub>FDR<\/jats:sub> = 0.04) and lateral ( B = \u22120.39, p <jats:sub>FDR<\/jats:sub> = 0.04) orbitofrontal cortices as well as the cuneus ( B = \u22120.47, p <jats:sub>FDR<\/jats:sub> = 0.03) and the pericalcarine ( B = \u22120.45, p <jats:sub>FDR<\/jats:sub> = 0.03) and lingual ( B = \u22120.38, p <jats:sub>FDR<\/jats:sub> = 0.04) gyri. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> Inference about developmental trajectories was limited by the cross-sectional data. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Psychotic symptoms in youth are associated with cortical folding deficits, even in the absence of psychotic illness. The current study helps clarify the neurodevelopmental basis of psychosis at an early stage, before medication, drug use and other confounds have had a persistent effect on the brain. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.180144","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T09:47:39Z","timestamp":1582710459000},"page":"125-133","source":"Crossref","is-referenced-by-count":10,"title":["Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness"],"prefix":"10.1139","volume":"45","author":[{"given":"Vladislav","family":"Drobinin","sequence":"first","affiliation":[{"name":"From the Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada"},{"name":"the Nova Scotia Health Authority, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Van Gestel","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Zwicker","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Pathology, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Cumby","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"Patterson","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Howes","family":"Vallis","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Psychiatry, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Campbell","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Medicine, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl A.","family":"Helmick","sequence":"additional","affiliation":[{"name":"From the Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada"},{"name":"the Department of Psychiatry, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"From the Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Alda","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Psychiatry, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris V.","family":"Bowen","sequence":"additional","affiliation":[{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"and the Department of Diagnostic Radiology, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Uher","sequence":"additional","affiliation":[{"name":"From the Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada"},{"name":"the Nova Scotia Health Authority, Halifax, NS"},{"name":"the Department of Pathology, Dalhousie University, Halifax, NS"},{"name":"the Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS"},{"name":"the Department of Psychiatry, Dalhousie University, Halifax, NS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-45-2-125\/b1-45-2-125_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","volume":"386","author":"Global Burden of Disease Study 2013 Collaborators","year":"2015","journal-title":"Lancet"},{"key":"b2-45-2-125\/b2-45-2-125_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/wps.20490","volume":"17","author":"Radua J","year":"2018","journal-title":"World Psychiatry"},{"key":"b3-45-2-125\/b3-45-2-125_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/mp.2012.23","volume":"17","author":"Rapoport JL","year":"2012","journal-title":"Mol Psychiatry"},{"key":"b4-45-2-125\/b4-45-2-125_1","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1038\/tp.2015.115","volume":"5","author":"Selemon LD","year":"2015","journal-title":"Transl Psychiatry"},{"key":"b5-45-2-125\/b5-45-2-125_1","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.2174\/156802612805289953","volume":"12","author":"White T","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"b6-45-2-125\/b6-45-2-125_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1109\/TMI.2007.903576","volume":"27","author":"Schaer M","year":"2008","journal-title":"IEEE Trans Med Imaging"},{"key":"b7-45-2-125\/b7-45-2-125_1","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1073\/pnas.0932745100","volume":"100","author":"Klyachko VA","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"b8-45-2-125\/b8-45-2-125_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1523\/JNEUROSCI.1106-17.2017","volume":"38","author":"Borrell V","year":"2018","journal-title":"J Neurosci"},{"key":"b9-45-2-125\/b9-45-2-125_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1523\/JNEUROSCI.1105-17.2017","volume":"38","author":"Kroenke CD","year":"2018","journal-title":"J Neurosci"},{"key":"b10-45-2-125\/b10-45-2-125_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.15252\/embj.201593701","volume":"35","author":"Fernandez V","year":"2016","journal-title":"EMBO J"},{"key":"b11-45-2-125\/b11-45-2-125_1","first-page":"13","volume":"2","author":"Schaer M","year":"2009","journal-title":"Eur Psychiatry Rev"},{"key":"b12-45-2-125\/b12-45-2-125_1","first-page":"56","volume":"5","author":"Armstrong E","year":"1995","journal-title":"Cereb Cortex N Y N 1991"},{"key":"b13-45-2-125\/b13-45-2-125_1","first-page":"1","author":"Zwicker A","year":"2018","journal-title":"Psychol Med"},{"key":"b14-45-2-125\/b14-45-2-125_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.biopsych.2013.11.018","volume":"76","author":"Nanda P","year":"2014","journal-title":"Biol Psychiatry"},{"key":"b15-45-2-125\/b15-45-2-125_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.schres.2013.11.032","volume":"152","author":"Nesvag R","year":"2014","journal-title":"Schizophr Res"},{"key":"b16-45-2-125\/b16-45-2-125_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jpsychires.2006.07.018","volume":"41","author":"Falkai P","year":"2007","journal-title":"J Psychiatr Res"},{"key":"b17-45-2-125\/b17-45-2-125_1","first-page":"673","volume":"43","author":"Liu B","year":"2017","journal-title":"Schizophr Bull"},{"key":"b18-45-2-125\/b18-45-2-125_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0166-2236(88)90060-4","volume":"11","author":"Weinberger DR","year":"1988","journal-title":"Trends Neurosci"},{"key":"b19-45-2-125\/b19-45-2-125_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0006-3223(96)00292-2","volume":"41","author":"Kulynych JJ","year":"1997","journal-title":"Biol Psychiatry"},{"key":"b20-45-2-125\/b20-45-2-125_1","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.biopsych.2010.12.012","volume":"69","author":"Palaniyappan L","year":"2011","journal-title":"Biol Psychiatry"},{"key":"b21-45-2-125\/b21-45-2-125_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/mp.2017.170","volume":"23","author":"Kelly S","year":"2018","journal-title":"Mol Psychiatry"},{"key":"b22-45-2-125\/b22-45-2-125_1","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1176\/appi.ajp.159.12.1983","volume":"159","author":"Selemon LD","year":"2002","journal-title":"Am J Psychiatry"},{"key":"b23-45-2-125\/b23-45-2-125_1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/jamapsychiatry.2013.203","volume":"70","author":"Palaniyappan L","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"b24-45-2-125\/b24-45-2-125_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1192\/bjp.bp.114.155796","volume":"207","author":"Guo S","year":"2015","journal-title":"Br J Psychiatry J Ment Sci"},{"key":"b25-45-2-125\/b25-45-2-125_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2011.1472","volume":"69","author":"Fusar-Poli P","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"b26-45-2-125\/b26-45-2-125_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12888-014-0344-2","volume":"14","author":"Uher R","year":"2014","journal-title":"BMC Psychiatry"},{"key":"b27-45-2-125\/b27-45-2-125_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","volume":"35","author":"Endicott J","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"b29-45-2-125\/b29-45-2-125_1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","volume":"36","author":"Kaufman J","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"b30-45-2-125\/b30-45-2-125_1","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"Wechsler D","year":"2011","edition":"2"},{"key":"b31-45-2-125\/b31-45-2-125_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.schbul.a007040","volume":"29","author":"Miller TJ","year":"2003","journal-title":"Schizophr Bull"},{"key":"b32-45-2-125\/b32-45-2-125_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1176\/appi.ajp.2010.10040567","volume":"168","author":"Arseneault L","year":"2011","journal-title":"Am J Psychiatry"},{"key":"b33-45-2-125\/b33-45-2-125_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpsyc.57.11.1053","volume":"57","author":"Poulton R","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"b34-45-2-125\/b34-45-2-125_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1001\/archgenpsychiatry.2010.14","volume":"67","author":"Polanczyk G","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"b35-45-2-125\/b35-45-2-125_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.schres.2013.02.014","volume":"146","author":"Fux L","year":"2013","journal-title":"Schizophr Res"},{"key":"b36-45-2-125\/b36-45-2-125_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/archpsyc.58.2.158","volume":"58","author":"Klosterkotter J","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"b37-45-2-125\/b37-45-2-125_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/138161212799316064","volume":"18","author":"Schultze-Lutter F","year":"2012","journal-title":"Curr Pharm Des"},{"key":"b38-45-2-125\/b38-45-2-125_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2015-2486","volume":"137","author":"MacKenzie LE","year":"2016","journal-title":"Pediatrics"},{"key":"b39-45-2-125\/b39-45-2-125_1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1017\/S0033291717001374","volume":"47","author":"MacKenzie LE","year":"2017","journal-title":"Psychol Med"},{"key":"b40-45-2-125\/b40-45-2-125_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuroimage.2013.04.127","volume":"80","author":"Glasser MF","year":"2013","journal-title":"NeuroImage"},{"key":"b41-45-2-125\/b41-45-2-125_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","volume":"14","author":"Fischl B","year":"2004","journal-title":"Cereb Cortex"},{"key":"b42-45-2-125\/b42-45-2-125_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"Desikan RS","year":"2006","journal-title":"NeuroImage"},{"key":"b44-45-2-125\/b44-45-2-125_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"b45-45-2-125\/b45-45-2-125_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pnpbp.2013.02.010","volume":"44","author":"Bartholomeusz CF","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"b46-45-2-125\/b46-45-2-125_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2010.05.006","volume":"121","author":"Takayanagi Y","year":"2010","journal-title":"Schizophr Res"},{"key":"b47-45-2-125\/b47-45-2-125_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41537-016-0008-y","volume":"3","author":"Isomura S","year":"2017","journal-title":"N P J Schizophr"},{"key":"b48-45-2-125\/b48-45-2-125_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(03)12323-9","volume":"361","author":"Pantelis C","year":"2003","journal-title":"Lancet"},{"key":"b49-45-2-125\/b49-45-2-125_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biopsych.2014.05.023","volume":"77","author":"Cannon TD","year":"2015","journal-title":"Biol Psychiatry"},{"key":"b50-45-2-125\/b50-45-2-125_1","doi-asserted-by":"crossref","first-page":"18041","DOI":"10.1073\/pnas.0806669105","volume":"105","author":"Homayoun H","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b51-45-2-125\/b51-45-2-125_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pneurobio.2008.09.001","volume":"86","author":"Rolls ET","year":"2008","journal-title":"Prog Neurobiol"},{"key":"b52-45-2-125\/b52-45-2-125_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.conb.2012.05.010","volume":"22","author":"Seo H","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"b53-45-2-125\/b53-45-2-125_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/schbul\/sbt050","volume":"40","author":"Palaniyappan L","year":"2014","journal-title":"Schizophr Bull"},{"key":"b54-45-2-125\/b54-45-2-125_1","doi-asserted-by":"crossref","first-page":"e0163749","DOI":"10.1371\/journal.pone.0163749","volume":"11","author":"Chang M","year":"2016","journal-title":"PLoS One"},{"key":"b55-45-2-125\/b55-45-2-125_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00429-011-0374-1","volume":"218","author":"Schultz CC","year":"2013","journal-title":"Brain S truct Funct"},{"key":"b56-45-2-125\/b56-45-2-125_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000382020","volume":"71","author":"Kong L","year":"2015","journal-title":"Neuropsychobiology Basel"},{"key":"b57-45-2-125\/b57-45-2-125_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ajmg.b.32515","volume":"174","author":"Thompson CA","year":"2017","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"b58-45-2-125\/b58-45-2-125_1","doi-asserted-by":"crossref","first-page":"e76815","DOI":"10.1371\/journal.pone.0076815","volume":"8","author":"Walton E","year":"2013","journal-title":"PLoS ONE"},{"key":"b59-45-2-125\/b59-45-2-125_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.biopsych.2017.05.018","volume":"82","author":"Sasabayashi D","year":"2017","journal-title":"Biol Psychiatry"},{"key":"b60-45-2-125\/b60-45-2-125_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dcn.2015.07.004","volume":"16","author":"Shollenbarger SG","year":"2015","journal-title":"Dev Cogn Neurosci"},{"key":"b61-45-2-125\/b61-45-2-125_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4088\/JCP.12r08287","volume":"74","author":"Spencer TJ","year":"2013","journal-title":"J Clin Psychiatry"},{"key":"b62-45-2-125\/b62-45-2-125_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/08897077.2014.995332","volume":"36","author":"Bagot KS","year":"2015","journal-title":"Subst Abuse"},{"key":"b63-45-2-125\/b63-45-2-125_1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/schbul\/sbs118","volume":"39","author":"Haijma SV","year":"2013","journal-title":"Schizophr Bull"},{"key":"b64-45-2-125\/b64-45-2-125_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","volume":"23","author":"Buckner RL","year":"2004","journal-title":"NeuroImage"},{"key":"b65-45-2-125\/b65-45-2-125_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.schres.2014.06.040","volume":"158","author":"Janssen J","year":"2014","journal-title":"Schizophr Res"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.180144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.180144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:43:16Z","timestamp":1756831396000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.180144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1503\/jpn.180144"],"URL":"https:\/\/doi.org\/10.1503\/jpn.180144","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}