{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:15Z","timestamp":1791888315439,"version":"4.3.4"},"reference-count":65,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Epigenetic variation in the serotonin transporter gene ( SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness. This study is, to our knowledge, the first to test this epigenome\u2013brain\u2013behaviour pathway in patients with anorexia nervosa. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We obtained resting-state functional connectivity (rsFC) data and blood samples from 55 acutely underweight female patients with anorexia nervosa and 55 age-matched female healthy controls. We decomposed imaging data using independent component analysis. We used bisulfite pyrosequencing to analyze blood DNA methylation within the promoter region of SLC6A4. We then explored salience network rsFC patterns in the group \u00d7 methylation interaction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We identified a positive relationship between SLC6A4 methylation levels and rsFC between the dorsolateral prefrontal cortex and the salience network in patients with anorexia nervosa compared to healthy controls. Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa. We confirmed findings of rsFC alterations for CpG-specific methylation at a locus with evidence of methylation correspondence between brain and blood tissue. Limitations: This study was cross-sectional in nature, the sample size was modest for the method and methylation levels were measured peripherally, so findings cannot be fully generalized to brain tissue. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.190016","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T08:53:00Z","timestamp":1588063980000},"page":"206-213","source":"Crossref","is-referenced-by-count":15,"title":["Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa"],"prefix":"10.1139","volume":"45","author":[{"given":"Ilka","family":"Boehm","sequence":"first","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Walton","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"the Department of Psychology, University of Bath, Bath, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Alexander","sequence":"additional","affiliation":[{"name":"the Department of Psychology, Faculty of Human Sciences, Medical School Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria-Luise","family":"Batury","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Seidel","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Geisler","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"King","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Weidner","sequence":"additional","affiliation":[{"name":"the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"the Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"From the Division of Psychological and Social Medicine and Developmental Neurosciences, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"and the Eating Disorders Research and Treatment Center at the Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-45-3-206\/b1-45-3-206_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/07853890008998829","volume":"32","author":"Halford JCG","year":"2000","journal-title":"Ann Med"},{"key":"b2-45-3-206\/b2-45-3-206_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn2682","volume":"10","author":"Kaye W","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"b3-45-3-206\/b3-45-3-206_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1468-2850.2011.01250.x","volume":"18","author":"Haynos AF","year":"2011","journal-title":"Clin Psychol Sci Pract"},{"key":"b4-45-3-206\/b4-45-3-206_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2017.04.054","volume":"218","author":"Marzola E","year":"2017","journal-title":"J Affect Disord"},{"key":"b5-45-3-206\/b5-45-3-206_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0006-3223(94)00173-Z","volume":"37","author":"Demitrack MA","year":"1995","journal-title":"Biol Psychiatry"},{"key":"b6-45-3-206\/b6-45-3-206_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1192\/bjp.172.5.439","volume":"172","author":"Monteleone P","year":"1998","journal-title":"Br J Psychiatry"},{"key":"b7-45-3-206\/b7-45-3-206_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.psyneuen.2013.09.009","volume":"39","author":"Gauthier C","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"b8-45-3-206\/b8-45-3-206_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archpsyc.1991.01810300068010","volume":"48","author":"Kaye W","year":"1991","journal-title":"Arch Gen Psychiatry"},{"key":"b9-45-3-206\/b9-45-3-206_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-2008-1078749","volume":"41","author":"Ehrlich S","year":"2008","journal-title":"Pharmacopsychiatry"},{"key":"b10-45-3-206\/b10-45-3-206_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archpsyc.62.9.1032","volume":"62","author":"Bailer U","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"b11-45-3-206\/b11-45-3-206_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0006-3223(02)01378-1","volume":"52","author":"Frank G","year":"2002","journal-title":"Biol Psychiatry"},{"key":"b12-45-3-206\/b12-45-3-206_1","first-page":"600","volume":"10","author":"Riva G","year":"2016","journal-title":"Front Hum Neurosci"},{"key":"b13-45-3-206\/b13-45-3-206_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/15622975.2015.1126675","volume":"17","author":"Solmi M","year":"2016","journal-title":"World J Biol Psychiatry"},{"key":"b14-45-3-206\/b14-45-3-206_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajmg.b.20142","volume":"127","author":"Abdolmaleky HM","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"b15-45-3-206\/b15-45-3-206_1","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1038\/tp.2014.37","volume":"4","author":"Wankerl M","year":"2014","journal-title":"Transl Psychiatry"},{"key":"b16-45-3-206\/b16-45-3-206_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/schbul\/sbv074","volume":"42","author":"Walton E","year":"2016","journal-title":"Schizophr Bull"},{"key":"b17-45-3-206\/b17-45-3-206_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1080\/15592294.2015.1100786","volume":"10","author":"Hannon E","year":"2015","journal-title":"Epigenetics"},{"key":"b18-45-3-206\/b18-45-3-206_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neubiorev.2016.11.011","volume":"72","author":"Palma-Gudiel H","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"b19-45-3-206\/b19-45-3-206_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jpsychires.2012.10.007","volume":"47","author":"Pjetri E","year":"2013","journal-title":"J Psychiatr Res"},{"key":"b20-45-3-206\/b20-45-3-206_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1503\/jpn.170242","volume":"44","author":"Steiger H","year":"2019","journal-title":"J Psychiatry Neurosci"},{"key":"b21-45-3-206\/b21-45-3-206_1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/mp.2012.124","volume":"18","author":"Miller R","year":"2013","journal-title":"Mol Psychiatry"},{"key":"b22-45-3-206\/b22-45-3-206_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biopsych.2016.12.030","volume":"82","author":"Bogdan R","year":"2017","journal-title":"Biol Psychiatry"},{"key":"b23-45-3-206\/b23-45-3-206_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1503\/jpn.140099","volume":"40","author":"Booij L","year":"2015","journal-title":"J Psychiatry Neurosci"},{"key":"b24-45-3-206\/b24-45-3-206_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","volume":"15","author":"Menon V","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"b25-45-3-206\/b25-45-3-206_1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/hbm.20639","volume":"30","author":"Meyer-Lindenberg A","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"b26-45-3-206\/b26-45-3-206_1","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","volume":"27","author":"Seeley WW","year":"2007","journal-title":"J Neurosci"},{"key":"b27-45-3-206\/b27-45-3-206_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neubiorev.2016.09.032","volume":"71","author":"Gaudio S","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"b28-45-3-206\/b28-45-3-206_1","doi-asserted-by":"crossref","first-page":"e01205","DOI":"10.1002\/brb3.1205","volume":"9","author":"Uniacke B","year":"2019","journal-title":"Brain Behav"},{"key":"b29-45-3-206\/b29-45-3-206_1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn.3778","volume":"17","author":"Nikolova YS","year":"2014","journal-title":"Nat Neurosci"},{"key":"b30-45-3-206\/b30-45-3-206_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1503\/jpn.140180","volume":"40","author":"Frodl T","year":"2015","journal-title":"J Psychiatry Neurosci"},{"key":"b31-45-3-206\/b31-45-3-206_1","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1002\/hbm.22923","volume":"36","author":"Muehlhan M","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"b32-45-3-206\/b32-45-3-206_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41398-018-0195-6","volume":"8","author":"Ismaylova E","year":"2018","journal-title":"Transl Psychiatry"},{"key":"b33-45-3-206\/b33-45-3-206_1","volume-title":"SIAB. Struckturiertes Inventar fuer anorektische und Bulimische Essstoerungen nach DSM-IV und ICD-10","author":"Fichter M","year":"1999"},{"key":"b34-45-3-206\/b34-45-3-206_1","volume-title":"Wechsler Intelligenztest f\u00fcr Erwachsene (WIE) Deutschsprachige Bearbeitung und Adaptation des WAIS-III von David Wechsler","author":"Von Aster M","year":"2006"},{"key":"b35-45-3-206\/b35-45-3-206_1","doi-asserted-by":"crossref","DOI":"10.1026\/0942-5403.17.2.71","volume-title":"HAWIK-IV: Hamburg-Wechsler Intelligenztest f\u00fcr Kinder-IV","author":"Petermann F","year":"2008"},{"key":"b36-45-3-206\/b36-45-3-206_1","volume-title":"Eating Disorder Inventory-2 (EDI-2): Deutsche Version","author":"Paul T","year":"2005"},{"key":"b37-45-3-206\/b37-45-3-206_1","volume-title":"Beck Depressions-Inventar: BDI II; Manual","author":"Hautzinger M","year":"2009"},{"key":"b38-45-3-206\/b38-45-3-206_1","volume-title":"SCL-90-R Symptom-Checklist von L.R. Derogatis\u2014Deutsche Version","author":"Franke G","year":"2002"},{"key":"b39-45-3-206\/b39-45-3-206_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ajmg.b.30414","volume":"144","author":"Philibert R","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"b40-45-3-206\/b40-45-3-206_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hup.2527","volume":"31","author":"Iga J-I","year":"2016","journal-title":"Hum Psychopharmacol"},{"key":"b41-45-3-206\/b41-45-3-206_1","doi-asserted-by":"crossref","first-page":"e1187","DOI":"10.1038\/tp.2017.171","volume":"7","author":"Edgar RD","year":"2017","journal-title":"Transl Psychiatry"},{"key":"b42-45-3-206\/b42-45-3-206_1","first-page":"1","volume":"45","author":"van Buuren S","year":"2011","journal-title":"J Stat Softw"},{"key":"b44-45-3-206\/b44-45-3-206_1","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/hbm.21170","volume":"32","author":"Erhardt EB","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"b45-45-3-206\/b45-45-3-206_1","doi-asserted-by":"crossref","first-page":"150259","DOI":"10.1503\/jpn.150259","volume":"41","author":"Boehm I","year":"2016","journal-title":"J Psychiatry Neurosci"},{"key":"b46-45-3-206\/b46-45-3-206_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3389\/fnbeh.2014.00346","volume":"8","author":"Boehm I","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"b47-45-3-206\/b47-45-3-206_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","volume":"106","author":"Yeo BT","year":"2011","journal-title":"J Neurophysiol"},{"key":"b48-45-3-206\/b48-45-3-206_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/BF00971709","volume":"12","author":"Reader TA","year":"1987","journal-title":"Neurochem Res"},{"key":"b49-45-3-206\/b49-45-3-206_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s001120170107","volume":"149","author":"Kromeyer-Hauschild K","year":"2001","journal-title":"Monatsschr Kinderheilkd"},{"key":"b50-45-3-206\/b50-45-3-206_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/eat.22374","volume":"48","author":"Booij L","year":"2015","journal-title":"Int J Eat Disord"},{"key":"b51-45-3-206\/b51-45-3-206_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrn3857","volume":"16","author":"Uddin LQ","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"b52-45-3-206\/b52-45-3-206_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0959-4388(03)00090-4","volume":"13","author":"Craig A","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"b53-45-3-206\/b53-45-3-206_1","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/hbm.22736","volume":"36","author":"Ehrlich S","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"b54-45-3-206\/b54-45-3-206_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1503\/jpn.140310","volume":"41","author":"Geisler D","year":"2016","journal-title":"J Psychiatry Neurosci"},{"key":"b55-45-3-206\/b55-45-3-206_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/erv.890","volume":"16","author":"Nunn K","year":"2008","journal-title":"Eur Eat Disord Rev"},{"key":"b56-45-3-206\/b56-45-3-206_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.euroneuro.2017.07.005","volume":"27","author":"Ismaylova E","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"key":"b57-45-3-206\/b57-45-3-206_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/mp.2016.82","volume":"22","author":"Swartz JR","year":"2017","journal-title":"Mol Psychiatry"},{"key":"b58-45-3-206\/b58-45-3-206_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2014.16.1\/adayer","volume":"16","author":"Dayer A","year":"2014","journal-title":"Dialogues Clin Neurosci"},{"key":"b59-45-3-206\/b59-45-3-206_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/cercor\/bhu185","volume":"26","author":"Comte M","year":"2016","journal-title":"Cereb Cortex"},{"key":"b60-45-3-206\/b60-45-3-206_1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/cercor\/bhq216","volume":"21","author":"Kanske P","year":"2011","journal-title":"Cereb Cortex"},{"key":"b61-45-3-206\/b61-45-3-206_1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1176\/appi.ajp.2007.07040575","volume":"164","author":"Wagner A","year":"2007","journal-title":"Am J Psychiatry"},{"key":"b62-45-3-206\/b62-45-3-206_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1017\/S0033291717002161","volume":"48","author":"Boehm I","year":"2017","journal-title":"Psychol Med"},{"key":"b63-45-3-206\/b63-45-3-206_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.psyneuen.2019.03.033","volume":"106","author":"Alexander N","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"b64-45-3-206\/b64-45-3-206_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10578-007-0086-1","volume":"39","author":"Salbach-Andrae H","year":"2008","journal-title":"Child Psychiatry Hum Dev"},{"key":"b65-45-3-206\/b65-45-3-206_1","doi-asserted-by":"crossref","first-page":"e444","DOI":"10.1038\/tp.2014.83","volume":"4","author":"Roberts S","year":"2014","journal-title":"Transl Psychiatry"},{"key":"b66-45-3-206\/b66-45-3-206_1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1017\/S1461145713000710","volume":"16","author":"Asai T","year":"2013","journal-title":"Int J Neuropsychopharmacol"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.190016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.190016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:34:11Z","timestamp":1756830851000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.190016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1503\/jpn.190016"],"URL":"https:\/\/doi.org\/10.1503\/jpn.190016","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}