{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:36:38Z","timestamp":1791549398090,"version":"4.3.4"},"reference-count":62,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The sense of agency is an important aspect of motor control. Impaired sense of agency has been linked to several medical conditions, including schizophrenia and functional neurological disorders. A complex brain network subserves the sense of agency, and the right temporoparietal junction is one of its main nodes. In this paper, we tested whether transcranial magnetic stimulation over the right temporoparietal junction elicited behavioural changes in the sense of agency. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> In experiment 1, 15 healthy participants performed a behavioural task during functional MRI, with the goal of localizing the area relevant for the sense of agency in the right temporoparietal junction. In the task, the movement of a cursor (controlled by the participants) was artificially manipulated, and the sense of agency was either diminished (turbulence) or enhanced (magic). In experiment 2, we applied transcranial magnetic stimulation in 20 healthy participants in a sham-controlled, crossover trial with excitatory, inhibitory or sham (vertex) stimulation. We measured the summary agency score, an indicator of the sense of agency (lower values correspond to diminished sense of agency). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Experiment 1 revealed a peak of activation during agency manipulation in the right temporoparietal junction (Montreal Neurological Institute coordinates x, y, z: 68, \u221226, 34). Experiment 2 showed that inhibition of the right temporoparietal junction significantly reduced the summary agency score in both turbulence (from \u221214.4 \u00b1 11.4% to \u221222.5 \u00b1 8.9%), and magic (from \u22120.7 \u00b1 5.8% to \u22124.4 \u00b1 4.4%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p> We found no excitatory effects, possibly because of a ceiling effect (because healthy participants have a normal sense of agency) or noneffectiveness of the excitatory protocol. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Our experiments showed that the network subserving the sense of agency was amenable to neuromodulation in healthy participants. This sets the ground for further research in patients with impaired sense of agency. <\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial identification<\/jats:title><jats:p> DRKS00012992 (German clinical trials registry). <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.190099","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T12:20:06Z","timestamp":1593174006000},"page":"271-278","source":"Crossref","is-referenced-by-count":24,"title":["Transcranial magnetic stimulation over the right temporoparietal junction influences the sense of agency in healthy humans"],"prefix":"10.1139","volume":"45","author":[{"given":"Giuseppe A.","family":"Zito","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland"},{"name":"the Support Centre for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University 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