{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:00:34Z","timestamp":1770458434404,"version":"3.49.0"},"reference-count":59,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH levels in the amygdala were negatively correlated with functional connectivity between the amygdala and prefrontal cortex, subserving stress and affect control. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Thirty-one healthy participants completed positron emission tomography (PET) imaging with the FAAH probe [C-11]CURB, and resting-state functional MRI scans. Participants were genotyped for the FAAH polymorphism rs324420, and trait neuroticism was assessed. We calculated amygdala functional connectivity using pre-determined regions of interest (including the subgenual ventromedial prefrontal cortex [sgvmPFC] and the dorsal anterior cingulate cortex [dACC]) and a seed-to-voxel approach. We conducted correlation analyses on functional connectivity, with amygdala [C-11]CURB binding as a variable of interest. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The strength of amygdala functional connectivity with the sgvmPFC and dACC was negatively correlated with [C-11]CURB binding in the amygdala (sgvmPFC: r = \u22120.38, q = 0.04; dACC: r = \u22120.44; q = 0.03). Findings were partly replicated using the seed-to-voxel approach, which showed a cluster in the ventromedial prefrontal cortex, including voxels in the dACC but not the sgvmPFC (cluster-level, family-wise error rate corrected p &lt; 0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p> We did not replicate earlier findings of a relationship between an FAAH polymorphism (rs324420) and amygdala functional connectivity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our data provide preliminary evidence that lower levels of FAAH in the amygdala relate to increased frontoamygdalar functional coupling. Our findings were consistent with the role of FAAH in regulating brain circuits that underlie fear and emotion processing in humans. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.200010","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T16:14:52Z","timestamp":1615997692000},"page":"E238-E246","source":"Crossref","is-referenced-by-count":19,"title":["Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals"],"prefix":"10.1139","volume":"46","author":[{"given":"Duncan G.J.","family":"Green","sequence":"first","affiliation":[{"name":"From the Addiction Imaging Research Group, Toronto, Ont., Canada"},{"name":"the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhee","family":"Kim","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Ont., Canada"},{"name":"the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Kish","sequence":"additional","affiliation":[{"name":"the Human Brain Lab, Toronto, Ont., Canada"},{"name":"the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada"},{"name":"the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada"},{"name":"the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada"},{"name":"the Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel F.","family":"Tyndale","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Ont., Canada"},{"name":"the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada"},{"name":"the Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew N.","family":"Hill","sequence":"additional","affiliation":[{"name":"the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, Departments of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, Alta., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Ont., Canada"},{"name":"the Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont., Canada"},{"name":"the Departments of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Ont., Canada"},{"name":"the Morton and Gloria Shulman Movement Disorder Unit and E.J. 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