{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:17:28Z","timestamp":1790860648833,"version":"4.1.0"},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> A naturally occurring loss-of-function mutation in the gene for C-C chemokine receptor type 5 ( CCR5-\u039432) has recently been reported as a protective factor in post-stroke motor and cognitive recovery. We sought to examine whether this mutation also prevented the development of depressive symptoms up to 2 years after a stroke. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Participants were survivors of a first-ever mild to moderate ischemic stroke or transient ischemic attack from the TABASCO prospective study who underwent a 3 T MRI at baseline and were examined by a multiprofessional team 6, 12 and 24 months after the event, including an evaluation of depressive symptoms using the Geriatric Depression Scale. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> CCR5-\u039432 status and a baseline depression evaluation were available for 435 patients. Compared with noncarriers, CCR5-\u039432 carriers (16.1%) had fewer depressive symptoms at admission ( p = 0.035) and at 6 months ( p &lt; 0.001), 12 months ( p &lt; 0.001) and 24 months ( p = 0.006) after the index event. This association remained significant at 6 and 12 months after adjustment for age, sex, education, antidepressant use, ethnicity and the presence of cortical infarcts. These findings were more robust in women. Compared to baseline, depressive symptoms in CCR5-\u039432 noncarriers tended to remain stable or grow worse over time, but in CCR5-\u039432 carriers, symptoms tended to improve. Limitations: A limitation of this study was the exclusion of patients who had a severe stroke or who had pre-stroke depression. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Carriers of the CCR5-\u039432 allele had a lower tendency to develop depressive symptoms post-stroke, and this phenomenon was more prominent in women. These findings could have clinical implications; they suggest a mechanism-based treatment target for post-stroke depression. Drugs mimicking this loss-of-function mutation exist and could serve as a novel antidepressant therapy. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.200197","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T07:55:21Z","timestamp":1626940521000},"page":"E431-E440","source":"Crossref","is-referenced-by-count":12,"title":["<i>CCR5<\/i>-\u039432 polymorphism: a possible protective factor for post-stroke depressive symptoms"],"prefix":"10.1139","volume":"46","author":[{"given":"Oren","family":"Tene","sequence":"first","affiliation":[{"name":"From the Departments of Neurology and Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"},{"name":"the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hen","family":"Hallevi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, 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