{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:53:30Z","timestamp":1784159610414,"version":"3.55.0"},"reference-count":77,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2022,4,27]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> For decades, the dopamine D2 receptor (D2R) has been known as the main target of antipsychotic medications, but the mechanism for antipsychotic effects beyond this pharmacological target remains unclear. Disrupted-in-schizophrenia 1 ( DISC1) is a gene implicated in the etiology of schizophrenia, and we have found elevated levels of the D2R-DISC1 complex in the postmortem brain tissue of patients with schizophrenia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We used coimmunoprecipitation to measure D2R-DISC1 complex levels in peripheral blood samples from patients with schizophrenia and unaffected controls in 3 cohorts (including males and females) from different hospitals. We also used label-free mass spectrometry to conduct proteomic analysis of these samples. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Levels of the D2R-DISC1 complex were elevated in the peripheral blood samples of patients with schizophrenia from 3 independent cohorts, and were normalized with antipsychotic treatment. Proteomic analysis of the blood samples from patients with high D2R-DISC1 complex levels that were normalized with antipsychotic treatment revealed a number of altered proteins and pathways associated with D2R, DISC1 and the D2R-DISC1 complex. We identified additional proteins and pathways that were associated with antipsychotic treatment in schizophrenia, and that may also be novel targets for schizophrenia treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p> Sample sizes were relatively small, but were sufficient to detect associations between D2R-DISC1 levels, schizophrenia and treatment response. The relevance of leukocyte changes to the symptoms of schizophrenia is unknown. The coimmunoprecipitation lanes included several nonspecific bands. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Levels of the D2R-DISC1 complex were elevated in patients with schizophrenia and reduced with antipsychotic treatment. This finding reinforces the independent role of each protein in schizophrenia. Our results enhanced our understanding of the molecular pathways involved in schizophrenia and in antipsychotic medications, and identified novel potential molecular targets for treating schizophrenia. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.210145","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:15:32Z","timestamp":1648714532000},"page":"E134-E147","source":"Crossref","is-referenced-by-count":14,"title":["The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment"],"prefix":"10.1139","volume":"47","author":[{"given":"Jijun","family":"Wang","sequence":"first","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Su","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"the National Clinical Research Centre for Mental Disorders, Beijing AnDing Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Yuan","sequence":"additional","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Li","sequence":"additional","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dong","sequence":"additional","affiliation":[{"name":"the National Clinical Research Centre for Mental Disorders, Beijing AnDing Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"the National Clinical Research Centre for Mental Disorders, Beijing AnDing Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Samsom","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont."},{"name":"the Department of Pharmacology, University of Toronto, Toronto, Ont."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert H.C.","family":"Wong","sequence":"additional","affiliation":[{"name":"the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont."},{"name":"the Department of Pharmacology, University of Toronto, Toronto, Ont."},{"name":"the Institute of Medical Science, University of Toronto, Toronto, Ont."},{"name":"the Department of Psychiatry, University of Toronto, Toronto, Ont."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Shanghai Mental Health Centre, Shanghai Jiaotong University, School of Medicine, Shanghai, China"},{"name":"the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont."},{"name":"the Institute of Medical Science, University of Toronto, Toronto, Ont."},{"name":"the Department of Psychiatry, University of Toronto, Toronto, Ont."},{"name":"the Department of Physiology, University of Toronto, Toronto, Ont."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-47-2-e134\/b1-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.1145194","volume":"188","author":"Seeman P","year":"1975","journal-title":"Science"},{"key":"b2-47-2-e134\/b2-47-2-e134_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/261717a0","volume":"261","author":"Seeman P","year":"1976","journal-title":"Nature"},{"key":"b3-47-2-e134\/b3-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/bmj.321.7273.1371","volume":"321","author":"Geddes J","year":"2000","journal-title":"BMJ"},{"key":"b4-47-2-e134\/b4-47-2-e134_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.mp.4001777","volume":"11","author":"Insel TR","year":"2006","journal-title":"Mol Psychiatry"},{"key":"b5-47-2-e134\/b5-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","volume":"353","author":"Lieberman JA","year":"2005","journal-title":"N Engl J Med"},{"key":"b6-47-2-e134\/b6-47-2-e134_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(08)61764-X","volume":"373","author":"Leucht S","year":"2009","journal-title":"Lancet"},{"key":"b7-47-2-e134\/b7-47-2-e134_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","volume":"78","author":"Missale C","year":"1998","journal-title":"Physiol Rev"},{"key":"b8-47-2-e134\/b8-47-2-e134_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","volume":"49","author":"Beaulieu JM","year":"2009","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"b9-47-2-e134\/b9-47-2-e134_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.pharmtox.48.113006.094830","volume":"48","author":"Hanyaloglu AC","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"b10-47-2-e134\/b10-47-2-e134_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12035-011-8227-8","volume":"45","author":"Fukunaga K","year":"2012","journal-title":"Mol Neurobiol"},{"key":"b11-47-2-e134\/b11-47-2-e134_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/092986712803414259","volume":"19","author":"Fuxe K","year":"2012","journal-title":"Curr Med Chem"},{"key":"b12-47-2-e134\/b12-47-2-e134_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molmed.2011.09.002","volume":"17","author":"Porteous DJ","year":"2011","journal-title":"Trends Mol Med"},{"key":"b13-47-2-e134\/b13-47-2-e134_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0140-6736(90)91520-K","volume":"336","author":"St Clair D","year":"1990","journal-title":"Lancet"},{"key":"b14-47-2-e134\/b14-47-2-e134_1","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1093\/hmg\/ddg341","volume":"12","author":"Hennah W","year":"2003","journal-title":"Hum Mol Genet"},{"key":"b15-47-2-e134\/b15-47-2-e134_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.biopsych.2006.04.024","volume":"60","author":"Liu YL","year":"2006","journal-title":"Biol Psychiatry"},{"key":"b16-47-2-e134\/b16-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archpsyc.62.10.1081","volume":"62","author":"Hamshere ML","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"b17-47-2-e134\/b17-47-2-e134_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1086\/425586","volume":"75","author":"Hodgkinson CA","year":"2004","journal-title":"Am J Hum Genet"},{"key":"b18-47-2-e134\/b18-47-2-e134_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0888-7543(02)00026-5","volume":"81","author":"Taylor MS","year":"2003","journal-title":"Genomics"},{"key":"b19-47-2-e134\/b19-47-2-e134_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrn3120","volume":"12","author":"Brandon NJ","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"b20-47-2-e134\/b20-47-2-e134_1","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1523\/JNEUROSCI.3299-08.2008","volume":"28","author":"Shen S","year":"2008","journal-title":"J Neurosci"},{"key":"b21-47-2-e134\/b21-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2007.07.010","volume":"130","author":"Duan X","year":"2007","journal-title":"Cell"},{"key":"b22-47-2-e134\/b22-47-2-e134_1","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1073\/pnas.0802615105","volume":"105","author":"Kvajo M","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b23-47-2-e134\/b23-47-2-e134_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.mp.4002079","volume":"13","author":"Pletnikov MV","year":"2008","journal-title":"Mol Psychiatry"},{"key":"b24-47-2-e134\/b24-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cell.2008.12.044","volume":"136","author":"Mao Y","year":"2009","journal-title":"Cell"},{"key":"b25-47-2-e134\/b25-47-2-e134_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neuron.2010.01.019","volume":"65","author":"Niwa M","year":"2010","journal-title":"Neuron"},{"key":"b26-47-2-e134\/b26-47-2-e134_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.schres.2011.03.032","volume":"129","author":"Lee FH","year":"2011","journal-title":"Schizophr Res"},{"key":"b27-47-2-e134\/b27-47-2-e134_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2010.06.002","volume":"67","author":"Singh KK","year":"2010","journal-title":"Neuron"},{"key":"b28-47-2-e134\/b28-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cell.2011.12.037","volume":"148","author":"Kim JY","year":"2012","journal-title":"Cell"},{"key":"b29-47-2-e134\/b29-47-2-e134_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuron.2009.08.008","volume":"63","author":"Kim JY","year":"2009","journal-title":"Neuron"},{"key":"b30-47-2-e134\/b30-47-2-e134_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2009.08.015","volume":"63","author":"Enomoto A","year":"2009","journal-title":"Neuron"},{"key":"b31-47-2-e134\/b31-47-2-e134_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2007.04.015","volume":"54","author":"Clapcote SJ","year":"2007","journal-title":"Neuron"},{"key":"b32-47-2-e134\/b32-47-2-e134_1","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1523\/JNEUROSCI.4219-10.2011","volume":"31","author":"Lee FH","year":"2011","journal-title":"J Neurosci"},{"key":"b33-47-2-e134\/b33-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.neuron.2014.11.007","volume":"84","author":"Su P","year":"2014","journal-title":"Neuron"},{"key":"b34-47-2-e134\/b34-47-2-e134_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0920-9964(99)00192-9","volume":"44","author":"Torrey EF","year":"2000","journal-title":"Schizophr Res"},{"key":"b35-47-2-e134\/b35-47-2-e134_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbr.2014.08.064","volume":"275","author":"Trossbach SV","year":"2014","journal-title":"Behav Brain Res"},{"key":"b36-47-2-e134\/b36-47-2-e134_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0165-5728(02)00280-1","volume":"132","author":"McKenna F","year":"2002","journal-title":"J Neuroimmunol"},{"key":"b37-47-2-e134\/b37-47-2-e134_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0022-3956(84)90033-5","volume":"18","author":"Rossor M","year":"1984","journal-title":"J Psychiatr Res"},{"key":"b38-47-2-e134\/b38-47-2-e134_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(06)58001-X","volume":"158","author":"Webster MJ","year":"2006","journal-title":"Prog Brain Res"},{"key":"b39-47-2-e134\/b39-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/mp.2010.100","volume":"16","author":"Chan MK","year":"2011","journal-title":"Mol Psychiatry"},{"key":"b40-47-2-e134\/b40-47-2-e134_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.schres.2016.04.019","volume":"177","author":"Uhrig S","year":"2016","journal-title":"Schizophr Res"},{"key":"b41-47-2-e134\/b41-47-2-e134_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/15622975.2011.645877","volume":"14","author":"Wilmsdorff MV","year":"2013","journal-title":"World J Biol Psychiatry"},{"key":"b42-47-2-e134\/b42-47-2-e134_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ajmg.b.32361","volume":"168","author":"Abdolmaleky HM","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"b43-47-2-e134\/b43-47-2-e134_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molmed.2011.09.002","volume":"17","author":"Porteous DJ","year":"2011","journal-title":"Trends Mol Med"},{"key":"b44-47-2-e134\/b44-47-2-e134_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0149-7634(03)00035-6","volume":"27","author":"Wong AH","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"b45-47-2-e134\/b45-47-2-e134_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1176\/ajp.155.6.761","volume":"155","author":"Abi-Dargham A","year":"1998","journal-title":"Am J Psychiatry"},{"key":"b46-47-2-e134\/b46-47-2-e134_1","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.1073\/pnas.97.14.8104","volume":"97","author":"Abi-Dargham A","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b47-47-2-e134\/b47-47-2-e134_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-2999(00)00815-3","volume":"410","author":"Wong AH","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"b48-47-2-e134\/b48-47-2-e134_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"Kay SR","year":"1987","journal-title":"Schizophr Bull"},{"key":"b49-47-2-e134\/b49-47-2-e134_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2466\/pr0.1962.10.3.799","volume":"10","author":"Overall JE","year":"1962","journal-title":"Psychol Rep"},{"key":"b50-47-2-e134\/b50-47-2-e134_1","first-page":"22","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"b51-47-2-e134\/b51-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/nm.2263","volume":"16","author":"Pei L","year":"2010","journal-title":"Nat Med"},{"key":"b52-47-2-e134\/b52-47-2-e134_1","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/sj.emboj.7601656","volume":"26","author":"Lee FJ","year":"2007","journal-title":"EMBO J"},{"key":"b53-47-2-e134\/b53-47-2-e134_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"Ogata H","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"b54-47-2-e134\/b54-47-2-e134_1","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"Szklarczyk D","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"b55-47-2-e134\/b55-47-2-e134_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pharmthera.2009.06.001","volume":"124","author":"Molteni R","year":"2009","journal-title":"Pharmacol Ther"},{"key":"b56-47-2-e134\/b56-47-2-e134_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cellsig.2015.09.019","volume":"28","author":"Brandon NJ","year":"2016","journal-title":"Cell Signal"},{"key":"b57-47-2-e134\/b57-47-2-e134_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biopsych.2016.03.2104","volume":"81","author":"Weinstein JJ","year":"2017","journal-title":"Biol Psychiatry"},{"key":"b58-47-2-e134\/b58-47-2-e134_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/npp.2011.267","volume":"37","author":"Funk AJ","year":"2012","journal-title":"Neuropsychopharm"},{"key":"b59-47-2-e134\/b59-47-2-e134_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0006-3223(99)00104-3","volume":"46","author":"Kyosseva SV","year":"1999","journal-title":"Biol Psychiatry"},{"key":"b60-47-2-e134\/b60-47-2-e134_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/diseases7010022","volume":"7","author":"Matsuda S","year":"2019","journal-title":"Diseases"},{"key":"b61-47-2-e134\/b61-47-2-e134_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/wps.20693","volume":"19","author":"McCutcheon RA","year":"2020","journal-title":"World Psychiatry"},{"key":"b62-47-2-e134\/b62-47-2-e134_1","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkj109","volume":"34","author":"Stark C","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"b63-47-2-e134\/b63-47-2-e134_1","doi-asserted-by":"crossref","first-page":"D358","DOI":"10.1093\/nar\/gkt1115","volume":"42","author":"Orchard S","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"b64-47-2-e134\/b64-47-2-e134_1","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","volume":"47","author":"The UniProt Consortium","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"b65-47-2-e134\/b65-47-2-e134_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4001880","volume":"12","author":"Camargo LM","year":"2007","journal-title":"Mol Psychiatry"},{"key":"b66-47-2-e134\/b66-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbrc.2003.10.101","volume":"311","author":"Millar JK","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"b67-47-2-e134\/b67-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/hmg\/ddg162","volume":"12","author":"Morris JA","year":"2003","journal-title":"Hum Mol Genet"},{"key":"b68-47-2-e134\/b68-47-2-e134_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1073\/pnas.0136913100","volume":"100","author":"Ozeki Y","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b69-47-2-e134\/b69-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bbrc.2004.03.163","volume":"317","author":"Miyoshi K","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"b70-47-2-e134\/b70-47-2-e134_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1523\/JNEUROSCI.3825-06.2007","volume":"27","author":"Shinoda T","year":"2007","journal-title":"J Neurosci"},{"key":"b71-47-2-e134\/b71-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1126\/science.1112915","volume":"310","author":"Millar JK","year":"2005","journal-title":"Science"},{"key":"b72-47-2-e134\/b72-47-2-e134_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-007-0727-x","volume":"192","author":"Siuciak JA","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"b73-47-2-e134\/b73-47-2-e134_1","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1242\/dev.137075","volume":"143","author":"Yu JS","year":"2016","journal-title":"Development"},{"key":"b74-47-2-e134\/b74-47-2-e134_1","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1073\/pnas.93.17.9235","volume":"93","author":"Laruelle M","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"b75-47-2-e134\/b75-47-2-e134_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrg3240","volume":"13","author":"Sullivan PF","year":"2012","journal-title":"Nat Rev Genet"},{"key":"b76-47-2-e134\/b76-47-2-e134_1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/mp.2012.182","volume":"18","author":"Sullivan PF","year":"2013","journal-title":"Mol Psychiatry"},{"key":"b77-47-2-e134\/b77-47-2-e134_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/mp.2013.160","volume":"19","author":"Porteous DJ","year":"2014","journal-title":"Mol Psychiatry"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.210145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.210145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:41:29Z","timestamp":1756831289000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.210145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,27]]}},"alternative-id":["10.1503\/jpn.210145"],"URL":"https:\/\/doi.org\/10.1503\/jpn.210145","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}