{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:47:35Z","timestamp":1775854055109,"version":"3.50.1"},"reference-count":48,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Pediatric obsessive\u2013compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Before and after a symptom provocation task, youth with OCD ( n = 23; 9 boys; mean age \u00b1 standard deviation 15.1 \u00b1 2.6 years) and matched healthy controls ( n = 23) completed the Tower of London task during functional MRI scanning. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group \u00d7 time point interaction; t<jats:sub>44<\/jats:sub> = 5.22, p &lt; 0.001). In a seeded, region of interest\u2013constrained, functional connectivity analysis, we identified greater connectivity between the left superior frontal gyrus and the right middle frontal gyrus, left precuneus and left inferior parietal lobule in participants with OCD than healthy controls. We also identified greater connectivity between the right amygdala and right medial frontal gyrus in patients with OCD than healthy controls, but only before symptom provocation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> The fixed-order design of the study and the number of participants taking medication ( n = 20) should be noted. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Participants with OCD demonstrated greater amygdalar\u2013cortical connectivity before symptom provocation, while sustaining greater recruitment and connectivity of task-related planning areas throughout the task. These results suggest that brain activity and connectivity is altered after symptom provocation, in the absence of impaired planning performance. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.220064","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T11:01:49Z","timestamp":1669114909000},"page":"E409-E420","source":"Crossref","is-referenced-by-count":3,"title":["An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive\u2013compulsive disorder"],"prefix":"10.1139","volume":"47","author":[{"given":"Fern","family":"Jaspers-Fayer","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."},{"name":"the British Columbia Children\u2019s Hospital Research Institute, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Yao","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."},{"name":"the British Columbia Children\u2019s Hospital Research Institute, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Best","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."},{"name":"the British Columbia Children\u2019s Hospital Research Institute, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Lillevik","family":"Thorsen","sequence":"additional","affiliation":[{"name":"the Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway"},{"name":"the Centre for Crisis Psychology, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Negreiros","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Ellwyn","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyee","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, B.C."},{"name":"the British Columbia Children\u2019s Hospital Research Institute, Vancouver, B.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"de Wit","sequence":"additional","affiliation":[{"name":"the Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam Neuroscience, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile A.","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"the Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway"},{"name":"the Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam Neuroscience, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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