{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:34:36Z","timestamp":1792982076831,"version":"4.5.0"},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychiatry Neurosci"],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Signatures from the metabolome and microbiome have already been introduced as candidates for diagnostic and treatment support. The aim of this study was to investigate the utility of volatile organic compounds (VOCs) from the breath for detection of schizophrenia and depression. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Patients with a diagnosis of major depressive disorder (MDD) or schizophrenia, as well as healthy controls, were recruited to participate. After being clinically assessed and receiving instruction, each participant independently collected breath samples for subsequent examination by proton transfer\u2013reaction mass spectrometry. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The sample consisted of 104 participants: 36 patients with MDD, 34 patients with schizophrenia and 34 healthy controls. Through mixed-model and deep learning analyses, 5 VOCs contained in the participants\u2019 breath samples were detected that significantly differentiated between diagnostic groups and healthy controls, namely VOCs with mass-to-charge ratios ( m\/ z) 60, 69, 74, 88 and 90, which had classification accuracy of 76.8% to distinguish participants with MDD from healthy controls, 83.6% to distinguish participants with schizophrenia from healthy controls and 80.9% to distinguish participants with MDD from those with schizophrenia. No significant associations with medication, illness duration, age of onset or time in hospital were detected for these VOCs. <\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations:<\/jats:title><jats:p> The sample size did not allow generalization, and confounders such as nutrition and medication need to be tested. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study established promising results for the use of human breath gas for detection of schizophrenia and MDD. Two VOCs, 1 with m\/ z 60 (identified as trimethylamine) and 1 with m\/ z 90 (identified as butyric acid) could then be further connected to the interworking of the microbiota\u2013gut\u2013brain axis. <\/jats:p><\/jats:sec>","DOI":"10.1503\/jpn.220139","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T10:45:40Z","timestamp":1681296340000},"page":"E117-E125","source":"Crossref","is-referenced-by-count":22,"title":["Gut\u2013brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder"],"prefix":"10.1139","volume":"48","author":[{"given":"Daniush","family":"Henning","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"L\u00fcno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Jiang","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Meyer-Lotz","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hoeschen","sequence":"additional","affiliation":[{"name":"the Institute of Medicine Technics, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Frodl","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany"},{"name":"the Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Aachen, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"b1-48-2-e117\/b1-48-2-e117_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","volume":"386","author":"Global Burden of Disease Study Collaborators","year":"2015","journal-title":"Lancet"},{"key":"b2-48-2-e117\/b2-48-2-e117_1","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","volume":"3","author":"Mathers CD","year":"2006","journal-title":"PLoS Med"},{"key":"b3-48-2-e117\/b3-48-2-e117_1","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1371\/journal.pmed.0020141","volume":"2","author":"Saha S","year":"2005","journal-title":"PLoS Med"},{"key":"b4-48-2-e117\/b4-48-2-e117_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S2045796014000687","volume":"24","author":"Charlson FJ","year":"2015","journal-title":"Epidemiol Psychiatr Sci"},{"key":"b5-48-2-e117\/b5-48-2-e117_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-clinpsy-032813-153657","volume":"10","author":"Laursen TM","year":"2014","journal-title":"Annu Rev Clin Psychol"},{"key":"b6-48-2-e117\/b6-48-2-e117_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/0269881111431748","volume":"26","author":"Schlaepfer TE","year":"2012","journal-title":"J Psychopharmacol"},{"key":"b7-48-2-e117\/b7-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/schbul\/sbs130","volume":"39","author":"J\u00e4\u00e4skel\u00e4inen E","year":"2013","journal-title":"Schizophr Bull"},{"key":"b8-48-2-e117\/b8-48-2-e117_1","first-page":"23","volume":"58","author":"Thase ME","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"b9-48-2-e117\/b9-48-2-e117_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.aad6469","volume":"359","author":"Gandal MJ","year":"2018","journal-title":"Science"},{"key":"b10-48-2-e117\/b10-48-2-e117_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neubiorev.2017.10.001","volume":"83","author":"Pinto JV","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"b11-48-2-e117\/b11-48-2-e117_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41398-020-0835-5","volume":"10","author":"Carvalho AF","year":"2020","journal-title":"Transl Psychiatry"},{"key":"b12-48-2-e117\/b12-48-2-e117_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1503\/jpn.170053","volume":"43","author":"Tomioka Y","year":"2018","journal-title":"J Psychiatry Neurosci"},{"key":"b13-48-2-e117\/b13-48-2-e117_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41380-019-0585-z","volume":"25","author":"Kennis M","year":"2020","journal-title":"Mol Psychiatry"},{"key":"b14-48-2-e117\/b14-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/mp.2016.3","volume":"21","author":"Goldsmith DR","year":"2016","journal-title":"Mol Psychiatry"},{"key":"b15-48-2-e117\/b15-48-2-e117_1","doi-asserted-by":"crossref","first-page":"026007","DOI":"10.1088\/1752-7163\/aa6ac6","volume":"11","author":"Siegel AP","year":"2017","journal-title":"J Breath Res"},{"key":"b16-48-2-e117\/b16-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2147\/NDT.S62289","volume":"11","author":"Dedovic K","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"b17-48-2-e117\/b17-48-2-e117_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.clinpsy.4.022007.141248","volume":"4","author":"Walker E","year":"2008","journal-title":"Annu Rev Clin Psychol"},{"key":"b18-48-2-e117\/b18-48-2-e117_1","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1038\/s41598-020-70993-0","volume":"10","author":"Sukul P","year":"2020","journal-title":"Sci Rep"},{"key":"b19-48-2-e117\/b19-48-2-e117_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/15622975.2022.2040052","volume":"23","author":"Jiang C","year":"2022","journal-title":"World J Biol Psychiatry"},{"key":"b20-48-2-e117\/b20-48-2-e117_1","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1002\/sim.8347","volume":"38","author":"Tan YV","year":"2019","journal-title":"Stat Med"},{"key":"b21-48-2-e117\/b21-48-2-e117_1","doi-asserted-by":"crossref","first-page":"eaau8317","DOI":"10.1126\/sciadv.aau8317","volume":"5","author":"Zheng P","year":"2019","journal-title":"Sci Adv"},{"key":"b22-48-2-e117\/b22-48-2-e117_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"Cryan JF","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"b23-48-2-e117\/b23-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.3390\/s17081859","volume":"17","author":"Kasper PL","year":"2017","journal-title":"Sensors (Basel)"},{"key":"b24-48-2-e117\/b24-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1920201","DOI":"10.1080\/20008198.2021.1920201","volume":"12","author":"Baranyi A","year":"2021","journal-title":"Eur J Psychotraumatol"},{"key":"b25-48-2-e117\/b25-48-2-e117_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13195-018-0451-2","volume":"10","author":"Vogt NM","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"b26-48-2-e117\/b26-48-2-e117_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1074\/mcp.M112.021816","volume":"12","author":"Zheng P","year":"2013","journal-title":"Mol Cell Proteomics"},{"key":"b27-48-2-e117\/b27-48-2-e117_1","first-page":"301","volume":"20","author":"Gatarek P","year":"2021","journal-title":"EXCLI J"},{"key":"b28-48-2-e117\/b28-48-2-e117_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40168-017-0271-9","volume":"5","author":"Rath S","year":"2017","journal-title":"Microbiome"},{"key":"b29-48-2-e117\/b29-48-2-e117_1","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.3390\/nu12082340","volume":"12","author":"Arias N","year":"2020","journal-title":"Nutrients"},{"key":"b30-48-2-e117\/b30-48-2-e117_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuro.2019.10.012","volume":"76","author":"Quan L","year":"2020","journal-title":"Neurotoxicology"},{"key":"b31-48-2-e117\/b31-48-2-e117_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.gastro.2010.11.049","volume":"140","author":"Spencer MD","year":"2011","journal-title":"Gastroenterology"},{"key":"b32-48-2-e117\/b32-48-2-e117_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnmol.2020.00018","volume":"13","author":"Espinoza S","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"b33-48-2-e117\/b33-48-2-e117_1","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.3390\/ijms22168802","volume":"22","author":"Vaganova AN","year":"2021","journal-title":"Int J Mol Sci"},{"key":"b34-48-2-e117\/b34-48-2-e117_1","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1021\/acs.analchem.9b00148","volume":"91","author":"Adam ME","year":"2019","journal-title":"Anal Chem"},{"key":"b35-48-2-e117\/b35-48-2-e117_1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.nucmedbio.2013.06.007","volume":"40","author":"Kim SW","year":"2013","journal-title":"Nucl Med Biol"},{"key":"b36-48-2-e117\/b36-48-2-e117_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","volume":"7","author":"Rios-Covian D","year":"2016","journal-title":"Front Microbiol"},{"key":"b37-48-2-e117\/b37-48-2-e117_1","doi-asserted-by":"crossref","first-page":"791466","DOI":"10.3389\/fcimb.2021.791466","volume":"11","author":"Sun X","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"b38-48-2-e117\/b38-48-2-e117_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"Erny D","year":"2015","journal-title":"Nat Neurosci"},{"key":"b39-48-2-e117\/b39-48-2-e117_1","doi-asserted-by":"crossref","first-page":"724664","DOI":"10.3389\/fpsyt.2021.724664","volume":"12","author":"Li X","year":"2021","journal-title":"Front Psychiatry"},{"key":"b40-48-2-e117\/b40-48-2-e117_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41398-020-01038-3","volume":"10","author":"Wu M","year":"2020","journal-title":"Transl Psychiatry"},{"key":"b41-48-2-e117\/b41-48-2-e117_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","volume":"625","author":"Bourassa MW","year":"2016","journal-title":"Neurosci Lett"},{"key":"b42-48-2-e117\/b42-48-2-e117_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1152\/jappl.2001.91.2.762","volume":"91","author":"Karl T","year":"2001","journal-title":"J Appl Physiol (1985)"},{"key":"b43-48-2-e117\/b43-48-2-e117_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1471-2407-9-348","volume":"9","author":"Bajtarevic A","year":"2009","journal-title":"BMC Cancer"},{"key":"b44-48-2-e117\/b44-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1080\/00207450390240059","volume":"113","author":"Kurup RK","year":"2003","journal-title":"Int J Neurosci"},{"key":"b45-48-2-e117\/b45-48-2-e117_1","doi-asserted-by":"crossref","first-page":"8295","DOI":"10.12998\/wjcc.v9.i28.8295","volume":"9","author":"Onaolapo OJ","year":"2021","journal-title":"World J Clin Cases"},{"key":"b46-48-2-e117\/b46-48-2-e117_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/ojpsych.2011.11001","volume":"1","author":"Ross BM","year":"2011","journal-title":"Open J Psychiatry"},{"key":"b47-48-2-e117\/b47-48-2-e117_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/YCO.0b013e3283366643","volume":"23","author":"Winterer G","year":"2010","journal-title":"Curr Opin Psychiatry"}],"container-title":["Journal of Psychiatry and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1503\/jpn.220139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1503\/jpn.220139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:34:30Z","timestamp":1756830870000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1503\/jpn.220139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,25]]}},"alternative-id":["10.1503\/jpn.220139"],"URL":"https:\/\/doi.org\/10.1503\/jpn.220139","relation":{},"ISSN":["1180-4882","1488-2434"],"issn-type":[{"value":"1180-4882","type":"print"},{"value":"1488-2434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]}}}