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The Hypothalamic-Pituitary Dysfunction Study Group of the Ministry of Health L, and Welfare, Japan (2009) The Guideline for the Diagnosis and Treatment of Adult GH Deficiency. Available at: http:\/\/square.umin.ac.jp\/kasuitai\/doctor\/guidance.html. Accessed June 20, 2012 (In Japanese)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"3. Fisker S, Jorgensen JOL, Orskov H, Christiansen JS (1998) L-arginine and insulin-tolerance tests in the diagnosis of adult growth hormone deficiency: influence of confounding factors. <i>Clin Endocrinol<\/i> 48:109-115.","DOI":"10.1046\/j.1365-2265.1998.00362.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"4. Rahim A, Toogood AA, Shalet SM (1996) The assessment of growth hormone status in normal young adult males using a variety of provocative agents. <i>Clin Endocrinol<\/i> 45:557-562.","DOI":"10.1046\/j.1365-2265.1996.00855.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420347"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0631"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2007.07.004"},{"key":"7","doi-asserted-by":"crossref","unstructured":"8. Biller BMK, Samuels MH, Zagar A, Cook DM, Arafah BM, et al. (2002) Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. <i>Endocrine Care<\/i> 87:2067-2079.","DOI":"10.1210\/jcem.87.5.8509"},{"key":"8","unstructured":"9. Aimaretti G, Corneli G, Razzore P, Bellone S, Baffoni C, et al. (1998) Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone plus arginine as provocative tests for the diagnosis of GH deficiency in adults. <i>J Clin Endocrinol Metab<\/i> 83:1615-1618."},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.379"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0066"},{"key":"11","doi-asserted-by":"crossref","unstructured":"13. Raiti S, Davis WT, Blizzard RM (1967) A comparison of effects of insuline hypoglycaemia and arginine infusion on release of human growth hormone. <i>Lancet<\/i> 2:1182-1183.","DOI":"10.1016\/S0140-6736(67)91896-X"},{"key":"12","doi-asserted-by":"crossref","unstructured":"14. Hanew K, Utsumi A (2002) The role of endogenous GHRH in arginine-, insulin-, clonidine- and L-dopa-induced GH release in normal subjects. <i>Eur J Endocrinol<\/i> 146:197-202.","DOI":"10.1530\/eje.0.1460197"},{"key":"13","doi-asserted-by":"crossref","unstructured":"15. Albaroth J, Muller OA, Schopohl J, Vonwerder K (1988) Arginine stimulates growth-hormone secretion by suppressing endogenous somatostatin secretion. <i>J Clin Endocrinol Metab<\/i> 67:1186-1189.","DOI":"10.1210\/jcem-67-6-1186"},{"key":"14","unstructured":"17. Doi N, Hirotani C, Ukai K, Shimada O, Okuno T, et al. (2004) Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. <i>Arzneimittelforschung<\/i> 54:857-867."},{"key":"15","doi-asserted-by":"crossref","unstructured":"18. Parker ML, Hammond JM, Daughada.Wh (1967) Arginine provocative test - an aid in diagnosis of hyposomatotropism. <i>J Clin Endocrinol Metab <\/i>27:1129-1136.","DOI":"10.1210\/jcem-27-8-1129"},{"key":"16","doi-asserted-by":"crossref","unstructured":"19. Ghigo E, Aimaretti G, Arvat E, Camanni F (2001) Growth hormone-releasing hormone combined with arginine or growth hormone secretagogues for the diagnosis of growth hormone deficiency in adults. <i>Endocrine<\/i> 15:29-38.","DOI":"10.1385\/ENDO:15:1:029"},{"key":"17","doi-asserted-by":"crossref","unstructured":"20. Cook DM, Yuen KCJ, Biller BMK, Kemp SF, Vance ML, et al. (2009) American association of clinical endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone - deficient adults and transition patients - 2009 update: executive summary of recommendations. <i>Endocr Pract<\/i> 15:580-586.","DOI":"10.4158\/EP.15.6.580"},{"key":"18","doi-asserted-by":"crossref","unstructured":"21. Cordido F, Alvarez-Castro P, Isidro ML, Casanueva FF, Dieguez C (2003) Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patients. <i>Eur J Endocrinol<\/i> 149:117-122.","DOI":"10.1530\/eje.0.1490117"},{"key":"19","doi-asserted-by":"crossref","unstructured":"22. Ghigo E, Procopio M, Boffano GM, Arvat E, Valente F, et al. (1992) Arginine potentiates but dose not restore the blunted growth-hormone response to growth hormone-releasing hormone in obesity. <i>Metabolism<\/i> 41:560-563.","DOI":"10.1016\/0026-0495(92)90220-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"23. Cordido F, Dieguez C, Casanueva FF (1990) Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth-hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. <i>J Clin Endocrinol Metab<\/i> 70:1361-1370.","DOI":"10.1210\/jcem-70-5-1361"},{"key":"21","doi-asserted-by":"crossref","unstructured":"24. Colao A, Di Somma C, Savastano S, Rota F, Savanelli MC, et al. (2009) A Reappraisal of Diagnosing GH Deficiency in Adults: Role of Gender, Age, Waist Circumference, and Body Mass Index. <i>J Clin Endocrinol Metab<\/i> 94:4414-4422.","DOI":"10.1210\/jc.2009-1134"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1450"},{"key":"23","doi-asserted-by":"crossref","unstructured":"26. Casanueva FF, Villanueva L, Dieguez C, Diaz Y, Cabranes JA, et al. (1987) Free fatty-acids block growth-hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. <i>J Clin Endocrinol Metab <\/i>65:634-642.","DOI":"10.1210\/jcem-65-4-634"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90249-6"},{"key":"25","unstructured":"29. Ministry of Health, Labour, and Welfare, Japan. (2009) National Health and Nutrition Survey. Available at: http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/kenkou_eiyou_chousa.html. Accessed June 20, 2012 (In Japanese)."},{"key":"26","unstructured":"30. McDowell MA, Fryar CD, Ogden CL, Flegal KM (2008) Anthropometric Reference Data for Children and Adults: United States, 2003-2006. Available at: http:\/\/www.cdc.gov\/nchs\/products\/nhsr.htm. 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