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The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. <i>N Engl J Med<\/i> 329: 977-986.","DOI":"10.1056\/NEJM199309303291401"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, <i>et al.<\/i> (1995) Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. <i>Diabetes Res Clin Pract <\/i>28: 103-117.","DOI":"10.1016\/0168-8227(95)01064-K"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, <i>et al.<\/i> (2012) International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. <i>J Diabetes Invest<\/i> 3: 39-40.","DOI":"10.1111\/j.2040-1124.2012.00207.x"},{"key":"4","unstructured":"4. Japan Diabetes Society (2007) Treatment Guide for Diabetes. Bunkodo, Tokyo."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, <i>et al.<\/i> (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. <i>Diabetes Care<\/i> 32: 193-203.","DOI":"10.2337\/dc08-9025"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. IDF Clinical Guidelines Task Force (2006) Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care. <i>Diabet Med<\/i> 23: 579-593.","DOI":"10.1111\/j.1464-5491.2006.01918.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Holman RR, Thorne KI, Farmer AJ, Davies MJ, Keenan JF, <i>et al.<\/i> (2007) Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes.<i> N Engl J Med<\/i> 357: 1716-1730.","DOI":"10.1056\/NEJMoa075392"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Holman RR, Farmer AJ, Davies MJ, Levy JC, Darbyshire JL, <i>et al.<\/i> (2009) Three-year efficacy of complex insulin regimens in type 2 diabetes. <i>N Engl J Med<\/i> 361: 1736-1747.","DOI":"10.1056\/NEJMoa0905479"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Raccah D, Bretzel RG, Owens D, Riddle M (2007) When basal insulin therapy in type 2 diabetes mellitus is not enough--what next? <i>Diabetes Metab Res Rev<\/i> 23: 257-264.","DOI":"10.1002\/dmrr.733"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hirsch IB (2005) Intensifying insulin therapy in patients with type 2 diabetes mellitus. <i>Am J Med<\/i> 118 Suppl 5A: 21S-26S.","DOI":"10.1016\/j.amjmed.2005.04.011"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Masuda H, Sakamoto M, Irie J, Kitaoka A, Shiono K, <i>et al.<\/i> (2008) Comparison of twice-daily injections of biphasic insulin lispro and basal-bolus therapy: glycaemic control and quality-of-life of insulin-naive type 2 diabetic patients. <i>Diabetes Obes Metab<\/i> 10: 1261-1265.","DOI":"10.1111\/j.1463-1326.2008.00897.x"},{"key":"12","unstructured":"12. Japan Council for Quality Health Care Division of Adverse Event Prevention (2010) Project to Collect and Analyze Pharmaceutical Near-Miss Event Information 2009 Annual Report. http:\/\/www.yakkyoku-hiyari.jcqhc.or.jp\/pdf\/year_report_english_2009.pdf"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. American Diabetes Association (2011) Standards of medical care in diabetes-2011. <i>Diabetes Care<\/i> 34 Suppl 1: S11-S61.","DOI":"10.2337\/dc11-S011"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. The Diabetes Control and Complications Trial Research Group (1997) Hypoglycemia in the Diabetes Control and Complications Trial. <i>Diabetes<\/i> 46: 271-286.","DOI":"10.2337\/diab.46.2.271"},{"key":"15","unstructured":"15. Mudaliar S, Henry RR (2003) The oral hypoglycemic agents. In: Porte D, Sherwin R, Baron A (eds) Ellenberg and Rifkin&rsquo;s Diabetes Mellitus (6<sup>th<\/sup>). McGraw-Hill New York: 531-564."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Goto A, Takaichi M, Kishimoto M, Takahashi Y, Kajio H, <i>et al.<\/i> (2010) Body Mass Index, Fasting Plasma Glucose Levels, and C-peptide Levels as Predictors of the Future Insulin Use in Japanese Type 2 Diabetic Patients. <i>Endocrine Journal<\/i> 57: 237-244.","DOI":"10.1507\/endocrj.K09E-279"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Polonsky KS, Given BD, Van CE (1988) Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. <i>J Clin Invest<\/i> 81: 442-448.","DOI":"10.1172\/JCI113339"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Herman WH, Ilag LL, Johnson SL, Martin CL, Sinding J, <i>et al.<\/i> (2005) A clinical trial of continuous subcutaneous insulin infusion versus multiple daily injections in older adults with type 2 diabetes.<i> Diabetes Care<\/i> 28: 1568-1573.","DOI":"10.2337\/diacare.28.7.1568"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Rosenstock J, Ahmann AJ, Colon G, Scism-Bacon J, Jiang H, <i>et al.<\/i> (2008) Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension\/lispro) versus basal\/bolus. <i>Diabetes Care<\/i> 31: 20-25.","DOI":"10.2337\/dc07-1122"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Jain SM, Mao X, Escalante-Pulido M, Vorokhobina N, Lopez I (2010) Prandial-basal insulin regimens plus oral antihyperglycaemic agents to improve mealtime glycaemia: initiate and progressively advance insulin therapy in type 2 diabetes. <i>Diabetes Obes Metab<\/i> 12: 967-975.","DOI":"10.1111\/j.1463-1326.2010.01287.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yoshioka N, Kurihara Y, Manda N, Komori K, Kato M, <i>et al.<\/i> (2009) Step-up therapy with biphasic insulin aspart-70\/30--Sapporo 1-2-3 study. <i>Diabetes Res Clin Pract<\/i> 85: 47-52.","DOI":"10.1016\/j.diabres.2009.04.012"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Monnier L, Colette C, Dunseath GJ, Owens DR (2007) The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes. <i>Diabetes Care<\/i> 30: 263-269.","DOI":"10.2337\/dc06-1612"},{"key":"23","unstructured":"23. 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