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Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors.<i> Cell<\/i> 131: 861-872.","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.<i> Cell<\/i> 126: 663-676.","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Benedum J (1999) The early history of endocrine cell transplantation.<i> J Mol Med (Berl)<\/i> 77: 30-35.","DOI":"10.1007\/s001090050296"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Merani S, Shapiro AM (2006) Current status of pancreatic islet transplantation.<i> Clin Sci (Lond)<\/i> 110: 611-625.","DOI":"10.1042\/CS20050342"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lindholm J, Laurberg P (2011) Hypothyroidism and thyroid substitution: historical aspects.<i> J Thyroid Res<\/i> 2011: 809341.","DOI":"10.4061\/2011\/809341"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Murray GR (1891) Note on the Treatment of Myxoedema by Hypodermic Injections of an Extract of the Thyroid Gland of a Sheep.<i> Br Med J<\/i> 2: 796-797.","DOI":"10.1136\/bmj.2.1606.796"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Eknoyan G (1995) A history of the parathyroid glands.<i> Am J Kidney Dis<\/i> 26: 801-807.","DOI":"10.1016\/0272-6386(95)90447-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, et al. (2005) Genetic determinants of pancreatic epsilon-cell development.<i> Dev Biol<\/i> 286: 217-224.","DOI":"10.1016\/j.ydbio.2005.06.041"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. (1995) U.K. prospective diabetes study 16. Overview of 6 years&rsquo; therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group.<i> Diabetes<\/i> 44: 1249-1258.","DOI":"10.2337\/diab.44.11.1249"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Imamura M, Maeda S (2011) Genetics of type 2 diabetes: the GWAS era and future perspectives [Review].<i> Endocr J<\/i> 58: 723-739.","DOI":"10.1507\/endocrj.EJ11-0113"},{"key":"11","unstructured":"11. Sanghera DK, Blackett PR (2012) Type 2 Diabetes Genetics: Beyond GWAS.<i> J Diabetes Metab<\/i> 3: 6948."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus.<i> Diabetes<\/i> 14: 619-633.","DOI":"10.2337\/diab.14.10.619"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?<i> Diabetologia<\/i> 48: 2221-2228.","DOI":"10.1007\/s00125-005-1949-2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, et al. (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.<i> Diabetes<\/i> 52: 102-110.","DOI":"10.2337\/diabetes.52.1.102"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic beta-cell mass in European subjects with type 2 diabetes.<i> Diabetes Obes Metab<\/i> 10 Suppl 4: 32-42.","DOI":"10.1111\/j.1463-1326.2008.00969.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. (1991) Epidemiology of severe hypoglycemia in the diabetes control and complications trial. The DCCT Research Group.<i> Am J Med<\/i> 90: 450-459.","DOI":"10.1016\/0002-9343(91)90605-W"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Allen C, LeCaire T, Palta M, Daniels K, Meredith M, et al. (2001) Risk factors for frequent and severe hypoglycemia in type 1 diabetes.<i> Diabetes Care<\/i> 24: 1878-1881.","DOI":"10.2337\/diacare.24.11.1878"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.<i> Lancet<\/i> 352: 837-853.","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kobayashi M, Yamazaki K, Hirao K, Oishi M, Kanatsuka A, et al. (2006) The status of diabetes control and antidiabetic drug therapy in Japan&mdash;a cross-sectional survey of 17,000 patients with diabetes mellitus (JDDM 1).<i> Diabetes Res Clin Pract<\/i> 73: 198-204.","DOI":"10.1016\/j.diabres.2006.01.013"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Meloche RM (2007) Transplantation for the treatment of type 1 diabetes.<i> World J Gastroenterol<\/i> 13: 6347-6355.","DOI":"10.3748\/wjg.v13.i47.6347"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Dieterle CD, Arbogast H, Illner WD, Schmauss S, Landgraf R (2007) Metabolic follow-up after long-term pancreas graft survival.<i> Eur J Endocrinol<\/i> 156: 603-610.","DOI":"10.1530\/EJE-06-0658"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Paty BW, Lanz K, Kendall DM, Sutherland DE, Robertson RP (2001) Restored hypoglycemic counterregulation is stable in successful pancreas transplant recipients for up to 19 years after transplantation.<i> Transplantation<\/i> 72: 1103-1107.","DOI":"10.1097\/00007890-200109270-00021"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Stratta RJ (2005) Surgical nuances in pancreas transplantation.<i> Transplant Proc<\/i> 37: 1291-1293.","DOI":"10.1016\/j.transproceed.2004.12.210"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, et al. (2005) Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience.<i> Am J Transplant<\/i> 5: 2037-2046.","DOI":"10.1111\/j.1600-6143.2005.00957.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, et al. (2005) Five-year follow-up after clinical islet transplantation.<i> Diabetes<\/i> 54: 2060-2069.","DOI":"10.2337\/diabetes.54.7.2060"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, et al. (2006) International trial of the Edmonton protocol for islet transplantation.<i> N Engl J Med<\/i> 355: 1318-1330.","DOI":"10.1056\/NEJMoa061267"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Gerber PA, Pavlicek V, Demartines N, Zuellig R, Pfammatter T, et al. (2008) Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up.<i> Diabetologia<\/i> 51: 110-119.","DOI":"10.1007\/s00125-007-0860-4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, et al. (2010) Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.<i> Transplantation<\/i> 90: 1595-1601.","DOI":"10.1097\/TP.0b013e3181fe1377"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Balamurugan AN, Breite AG, Anazawa T, Loganathan G, Wilhelm JJ, et al. (2010) Successful human islet isolation and transplantation indicating the importance of class 1 collagenase and collagen degradation activity assay.<i> Transplantation<\/i> 89: 954-961.","DOI":"10.1097\/TP.0b013e3181d21e9a"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Webb MA, Dennison AR, James RF (2012) The potential benefit of non-purified islets preparations for islet transplantation.<i> Biotechnol Genet Eng Rev<\/i> 28: 101-114.","DOI":"10.5661\/bger-28-101"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Egawa H, Tanabe K, Fukushima N, Date H, Sugitani A, et al. (2012) Current status of organ transplantation in Japan.<i> Am J Transplant<\/i> 12: 523-530.","DOI":"10.1111\/j.1600-6143.2011.03822.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yoshimura N, Okajima H, Ushigome H, Sakamoto S, Fujiki M, et al. (2010) Current status of organ transplantation in Japan and worldwide.<i> Surg Today<\/i> 40: 514-525.","DOI":"10.1007\/s00595-009-4214-3"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, et al. (2008) Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.<i> PLoS One<\/i> 3: e2435.","DOI":"10.1371\/journal.pone.0002435"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Burke GW, 3rd, Vendrame F, Pileggi A, Ciancio G, Reijonen H, et al. (2011) Recurrence of autoimmunity following pancreas transplantation.<i> Curr Diab Rep<\/i> 11: 413-419.","DOI":"10.1007\/s11892-011-0206-y"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Sutherland DE, Goetz FC, Sibley RK (1989) Recurrence of disease in pancreas transplants.<i> Diabetes<\/i> 38 Suppl 1: 85-87.","DOI":"10.2337\/diab.38.1.S85"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Murry CE, Keller G (2008) Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.<i> Cell<\/i> 132: 661-680.","DOI":"10.1016\/j.cell.2008.02.008"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Sasai Y (2013) Cytosystems dynamics in self-organization of tissue architecture.<i> Nature<\/i> 493: 318-326.","DOI":"10.1038\/nature11859"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Nostro MC, Keller G (2012) Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.<i> Semin Cell Dev Biol<\/i> 23: 701-710.","DOI":"10.1016\/j.semcdb.2012.06.010"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Sarjeant K, Stephens JM (2012) Adipogenesis.<i> Cold Spring Harb Perspect Biol<\/i> 4: a008417.","DOI":"10.1101\/cshperspect.a008417"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Pearse AG (1969) The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.<i> J Histochem Cytochem<\/i> 17: 303-313.","DOI":"10.1177\/17.5.303"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Lecoin L, Rocques N, El-Yakoubi W, Ben Achour S, Larcher M, et al. (2010) MafA transcription factor identifies the early ret-expressing sensory neurons.<i> Dev Neurobiol<\/i> 70: 485-497.","DOI":"10.1002\/dneu.20790"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Portela-Gomes GM, Hacker GW, Weitgasser R (2004) Neuroendocrine cell markers for pancreatic islets and tumors.<i> Appl Immunohistochem Mol Morphol<\/i> 12: 183-192.","DOI":"10.1097\/00129039-200409000-00001"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Andrew A, Kramer B (1979) An experimental investigation into the possible origin of pancreatic islet cells from rhombencephalic neurectoderm.<i> J Embryol Exp Morphol<\/i> 52: 23-38.","DOI":"10.1242\/dev.52.1.23"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Fontaine J, Le Lievre C, Le Douarin NM (1977) What is the developmental fate of the neural crest cells which migrate into the pancreas in the avian embryo?<i> Gen Comp Endocrinol<\/i> 33: 394-404.","DOI":"10.1016\/0016-6480(77)90055-7"},{"key":"45","unstructured":"45. Pearse AG (1979) The diffuse endocrine system and the implications of the APUD concept.<i> Int Surg<\/i> 64: 5-7."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Pictet RL, Rall LB, Phelps P, Rutter WJ (1976) The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells.<i> Science<\/i> 191: 191-192.","DOI":"10.1126\/science.1108195"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Lu CC, Brennan J, Robertson EJ (2001) From fertilization to gastrulation: axis formation in the mouse embryo.<i> Curr Opin Genet Dev<\/i> 11: 384-392.","DOI":"10.1016\/S0959-437X(00)00208-2"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Abe K, Niwa H, Iwase K, Takiguchi M, Mori M, et al. (1996) Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies.<i> Exp Cell Res<\/i> 229: 27-34.","DOI":"10.1006\/excr.1996.0340"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Duncan SA, Navas MA, Dufort D, Rossant J, Stoffel M (1998) Regulation of a transcription factor network required for differentiation and metabolism.<i> Science<\/i> 281: 692-695.","DOI":"10.1126\/science.281.5377.692"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Fujikura J, Yamato E, Yonemura S, Hosoda K, Masui S, et al. (2002) Differentiation of embryonic stem cells is induced by GATA factors.<i> Genes Dev<\/i> 16: 784-789.","DOI":"10.1101\/gad.968802"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Kwon GS, Viotti M, Hadjantonakis AK (2008) The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.<i> Dev Cell<\/i> 15: 509-520.","DOI":"10.1016\/j.devcel.2008.07.017"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Yasunaga M, Tada S, Torikai-Nishikawa S, Nakano Y, Okada M, et al. (2005) Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells.<i> Nat Biotechnol<\/i> 23: 1542-1550.","DOI":"10.1038\/nbt1167"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Kemp C, Willems E, Abdo S, Lambiv L, Leyns L (2005) Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.<i> Dev Dyn<\/i> 233: 1064-1075.","DOI":"10.1002\/dvdy.20408"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, et al. (1999) Requirement for Wnt3 in vertebrate axis formation.<i> Nat Genet<\/i> 22: 361-365.","DOI":"10.1038\/11932"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, et al. (1995) Lack of beta-catenin affects mouse development at gastrulation.<i> Development<\/i> 121: 3529-3537.","DOI":"10.1242\/dev.121.11.3529"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Zhou X, Sasaki H, Lowe L, Hogan BL, Kuehn MR (1993) Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.<i> Nature<\/i> 361: 543-547.","DOI":"10.1038\/361543a0"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ (2003) Cell fate decisions within the mouse organizer are governed by graded Nodal signals.<i> Genes Dev<\/i> 17: 1646-1662.","DOI":"10.1101\/gad.1100503"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK (2011) Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm.<i> Cell Stem Cell<\/i> 8: 335-346.","DOI":"10.1016\/j.stem.2011.01.017"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. McLean AB, D&rsquo;Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, et al. (2007) Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.<i> Stem Cells<\/i> 25: 29-38.","DOI":"10.1634\/stemcells.2006-0219"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Gadue P, Huber TL, Paddison PJ, Keller GM (2006) Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.<i> Proc Natl Acad Sci U S A<\/i> 103: 16806-16811.","DOI":"10.1073\/pnas.0603916103"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Tada S, Era T, Furusawa C, Sakurai H, Nishikawa S, et al. (2005) Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture.<i> Development<\/i> 132: 4363-4374.","DOI":"10.1242\/dev.02005"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. D&rsquo;Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, et al. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm.<i> Nat Biotechnol<\/i> 23: 1534-1541.","DOI":"10.1038\/nbt1163"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, et al. (2004) Development of definitive endoderm from embryonic stem cells in culture.<i> Development<\/i> 131: 1651-1662.","DOI":"10.1242\/dev.01044"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Wells JM, Melton DA (1999) Vertebrate endoderm development.<i> Annu Rev Cell Dev Biol<\/i> 15: 393-410.","DOI":"10.1146\/annurev.cellbio.15.1.393"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Wright CV, Schnegelsberg P, De Robertis EM (1989) XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm.<i> Development<\/i> 105: 787-794.","DOI":"10.1242\/dev.105.4.787"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice.<i> Nature<\/i> 371: 606-609.","DOI":"10.1038\/371606a0"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, et al. (1996) PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.<i> Development<\/i> 122: 983-995.","DOI":"10.1242\/dev.122.3.983"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, et al. (2005) Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.<i> Dev Biol<\/i> 284: 399-411.","DOI":"10.1016\/j.ydbio.2005.05.035"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Molotkov A, Molotkova N, Duester G (2005) Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.<i> Dev Dyn<\/i> 232: 950-957.","DOI":"10.1002\/dvdy.20256"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, et al. (2005) Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells.<i> Diabetes<\/i> 54: 301-305.","DOI":"10.2337\/diabetes.54.2.301"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Cai J, Yu C, Liu Y, Chen S, Guo Y, et al. (2010) Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.<i> J Mol Cell Biol<\/i> 2: 50-60.","DOI":"10.1093\/jmcb\/mjp037"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Robbins DJ, Fei DL, Riobo NA (2012) The Hedgehog signal transduction network.<i> Sci Signal<\/i> 5: re6.","DOI":"10.1126\/scisignal.2002906"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Beachy PA, Karhadkar SS, Berman DM (2004) Tissue repair and stem cell renewal in carcinogenesis.<i> Nature<\/i> 432: 324-331.","DOI":"10.1038\/nature03100"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Apelqvist A, Ahlgren U, Edlund H (1997) Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.<i> Curr Biol<\/i> 7: 801-804.","DOI":"10.1016\/S0960-9822(06)00340-X"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Hebrok M, Kim SK, Melton DA (1998) Notochord repression of endodermal Sonic hedgehog permits pancreas development.<i> Genes Dev<\/i> 12: 1705-1713.","DOI":"10.1101\/gad.12.11.1705"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Kim SK, Melton DA (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.<i> Proc Natl Acad Sci U S A<\/i> 95: 13036-13041.","DOI":"10.1073\/pnas.95.22.13036"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Tehrani Z, Lin S (2011) Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development.<i> Development<\/i> 138: 631-640.","DOI":"10.1242\/dev.050450"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA (2000) Regulation of pancreas development by hedgehog signaling.<i> Development<\/i> 127: 4905-4913.","DOI":"10.1242\/dev.127.22.4905"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Hebrok M (2003) Hedgehog signaling in pancreas development.<i> Mech Dev<\/i> 120: 45-57.","DOI":"10.1016\/S0925-4773(02)00331-3"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels.<i> Science<\/i> 294: 564-567.","DOI":"10.1126\/science.1064344"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Kumar M, Melton D (2003) Pancreas specification: a budding question.<i> Curr Opin Genet Dev<\/i> 13: 401-407.","DOI":"10.1016\/S0959-437X(03)00089-3"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Kumar M, Jordan N, Melton D, Grapin-Botton A (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate.<i> Dev Biol<\/i> 259: 109-122.","DOI":"10.1016\/S0012-1606(03)00183-0"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Deutsch G, Jung J, Zheng M, Lora J, Zaret KS (2001) A bipotential precursor population for pancreas and liver within the embryonic endoderm.<i> Development<\/i> 128: 871-881.","DOI":"10.1242\/dev.128.6.871"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Rossi JM, Dunn NR, Hogan BL, Zaret KS (2001) Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.<i> Genes Dev<\/i> 15: 1998-2009.","DOI":"10.1101\/gad.904601"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Shin D, Shin CH, Tucker J, Ober EA, Rentzsch F, et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish.<i> Development<\/i> 134: 2041-2050.","DOI":"10.1242\/dev.000281"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Johannesson M, Stahlberg A, Ameri J, Sand FW, Norrman K, et al. (2009) FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner.<i> PLoS One<\/i> 4: e4794.","DOI":"10.1371\/journal.pone.0004794"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Zhang D, Jiang W, Liu M, Sui X, Yin X, et al. (2009) Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.<i> Cell Res<\/i> 19: 429-438.","DOI":"10.1038\/cr.2009.28"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Mfopou JK, Chen B, Mateizel I, Sermon K, Bouwens L (2010) Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells.<i> Gastroenterology<\/i> 138: 2233-2245, 2245. e1-14.","DOI":"10.1053\/j.gastro.2010.02.056"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Kunisada Y, Tsubooka-Yamazoe N, Shoji M, Hosoya M (2012) Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells.<i> Stem Cell Res<\/i> 8: 274-284.","DOI":"10.1016\/j.scr.2011.10.002"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, et al. (2008) Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.<i> Nat Biotechnol<\/i> 26: 443-452.","DOI":"10.1038\/nbt1393"},{"key":"91","unstructured":"91. Ostrom M, Loffler KA, Edfalk S, Selander L, Dahl U, et al. (2008) Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.<i> PLoS One<\/i> 3: e2841."},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, et al. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.<i> J Biol Chem<\/i> 281: 15694-15700.","DOI":"10.1074\/jbc.M601252200"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, et al. (2001) Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.<i> Development<\/i> 128: 5109-5117.","DOI":"10.1242\/dev.128.24.5109"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Ye F, Duvillie B, Scharfmann R (2005) Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.<i> Diabetologia<\/i> 48: 277-281.","DOI":"10.1007\/s00125-004-1638-6"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Hart A, Papadopoulou S, Edlund H (2003) Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.<i> Dev Dyn<\/i> 228: 185-193.","DOI":"10.1002\/dvdy.10368"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Norgaard GA, Jensen JN, Jensen J (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.<i> Dev Biol<\/i> 264: 323-338.","DOI":"10.1016\/j.ydbio.2003.08.013"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Louvi A, Artavanis-Tsakonas S (2006) Notch signalling in vertebrate neural development.<i> Nat Rev Neurosci<\/i> 7: 93-102.","DOI":"10.1038\/nrn1847"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, et al. (1999) Notch signalling controls pancreatic cell differentiation.<i> Nature<\/i> 400: 877-881.","DOI":"10.1038\/23716"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, et al. (2006) Notch\/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.<i> Cell Metab<\/i> 3: 59-65.","DOI":"10.1016\/j.cmet.2005.12.005"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, et al. (2000) Control of endodermal endocrine development by Hes-1.<i> Nat Genet<\/i> 24: 36-44.","DOI":"10.1038\/71657"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101. Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, et al. (2011) Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.<i> Dev Biol<\/i> 349: 406-416.","DOI":"10.1016\/j.ydbio.2010.11.007"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102. Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.<i> Proc Natl Acad Sci U S A<\/i> 97: 1607-1611.","DOI":"10.1073\/pnas.97.4.1607"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, et al. (2006) Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.<i> Genes Dev<\/i> 20: 3130-3146.","DOI":"10.1101\/gad.1478706"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104. Raducanu A, Lickert H (2012) Understanding pancreas development for beta-cell repair and replacement therapies.<i> Curr Diab Rep<\/i> 12: 481-489.","DOI":"10.1007\/s11892-012-0301-8"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105. Ameri J, Stahlberg A, Pedersen J, Johansson JK, Johannesson MM, et al. (2010) FGF2 specifies hESC-derived definitive endoderm into foregut\/midgut cell lineages in a concentration-dependent manner.<i> Stem Cells<\/i> 28: 45-56.","DOI":"10.1002\/stem.249"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106. D&rsquo;Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.<i> Nat Biotechnol<\/i> 24: 1392-1401.","DOI":"10.1038\/nbt1259"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107. Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, et al. (2007) Generation of insulin-producing islet-like clusters from human embryonic stem cells.<i> Stem Cells<\/i> 25: 1940-1953.","DOI":"10.1634\/stemcells.2006-0761"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108. Micallef SJ, Li X, Schiesser JV, Hirst CE, Yu QC, et al. (2012) INS(GFP\/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells.<i> Diabetologia<\/i> 55: 694-706.","DOI":"10.1007\/s00125-011-2379-y"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109. Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, et al. (2011) Production of functional glucagon-secreting alpha-cells from human embryonic stem cells.<i> Diabetes<\/i> 60: 239-247.","DOI":"10.2337\/db10-0573"},{"key":"110","doi-asserted-by":"crossref","unstructured":"110. Xu X, Browning VL, Odorico JS (2011) Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells.<i> Mech Dev<\/i> 128: 412-427.","DOI":"10.1016\/j.mod.2011.08.001"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, et al. (2009) The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.<i> BMC Public Health<\/i> 9: 88.","DOI":"10.1186\/1471-2458-9-88"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112. Braun S, Bitton-Worms K, LeRoith D (2011) The Link between the Metabolic Syndrome and Cancer.<i> International Journal of Biological Sciences<\/i> 7: 1003-1015.","DOI":"10.7150\/ijbs.7.1003"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113. Tchernof A, Despres JP (2013) Pathophysiology of human visceral obesity: an update.<i> Physiol Rev<\/i> 93: 359-404.","DOI":"10.1152\/physrev.00033.2011"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114. Tran TT, Yamamoto Y, Gesta S, Kahn CR (2008) Beneficial effects of subcutaneous fat transplantation on metabolism.<i> Cell Metab<\/i> 7: 410-420.","DOI":"10.1016\/j.cmet.2008.04.004"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115. Garg A (2011) Clinical review#: Lipodystrophies: genetic and acquired body fat disorders.<i> J Clin Endocrinol Metab<\/i> 96: 3313-3325.","DOI":"10.1210\/jc.2011-1159"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, et al. (2000) Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.<i> J Clin Invest<\/i> 105: 271-278.","DOI":"10.1172\/JCI7901"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117. Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reitman ML (2000) Leptin and diabetes in lipoatrophic mice.<i> Nature<\/i> 403: 850; discussion 850-851.","DOI":"10.1038\/35002663"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118. Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, et al. (2002) Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.<i> Diabetes<\/i> 51: 2727-2733.","DOI":"10.2337\/diabetes.51.9.2727"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119. Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.<i> Nature<\/i> 401: 73-76.","DOI":"10.1038\/43448"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120. Konrad D, Rudich A, Schoenle EJ (2007) Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue.<i> Diabetologia<\/i> 50: 833-839.","DOI":"10.1007\/s00125-007-0596-1"},{"key":"121","doi-asserted-by":"crossref","unstructured":"121. Himms-Hagen J (1990) Brown adipose tissue thermogenesis: interdisciplinary studies.<i> FASEB J<\/i> 4: 2890-2898.","DOI":"10.1096\/fasebj.4.11.2199286"},{"key":"122","unstructured":"122. Hamann A, Flier JS, Lowell BB (1998) Obesity after genetic ablation of brown adipose tissue.<i> Z Ernahrungswiss<\/i> 37 Suppl 1: 1-7."},{"key":"123","doi-asserted-by":"crossref","unstructured":"123. Kontani Y, Wang Y, Kimura K, Inokuma KI, Saito M, et al. (2005) UCP1 deficiency increases susceptibility to diet-induced obesity with age.<i> Aging Cell<\/i> 4: 147-155.","DOI":"10.1111\/j.1474-9726.2005.00157.x"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, et al. (2013) Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.<i> J Clin Invest<\/i> 123: 215-223.","DOI":"10.1172\/JCI62308"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, et al. (2009) Identification and importance of brown adipose tissue in adult humans.<i> N Engl J Med<\/i> 360: 1509-1517.","DOI":"10.1056\/NEJMoa0810780"},{"key":"126","doi-asserted-by":"crossref","unstructured":"126. Takashima Y, Era T, Nakao K, Kondo S, Kasuga M, et al. (2007) Neuroepithelial cells supply an initial transient wave of MSC differentiation.<i> Cell<\/i> 129: 1377-1388.","DOI":"10.1016\/j.cell.2007.04.028"},{"key":"127","doi-asserted-by":"crossref","unstructured":"127. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al. (1999) Multilineage potential of adult human mesenchymal stem cells.<i> Science<\/i> 284: 143-147.","DOI":"10.1126\/science.284.5411.143"},{"key":"128","doi-asserted-by":"crossref","unstructured":"128. Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues.<i> Science<\/i> 276: 71-74.","DOI":"10.1126\/science.276.5309.71"},{"key":"129","doi-asserted-by":"crossref","unstructured":"129. Covas DT, Panepucci RA, Fontes AM, Silva WA Jr., Orellana MD, et al. (2008) Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts.<i> Exp Hematol<\/i> 36: 642-654.","DOI":"10.1016\/j.exphem.2007.12.015"},{"key":"130","doi-asserted-by":"crossref","unstructured":"130. Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, et al. (2008) White fat progenitor cells reside in the adipose vasculature.<i> Science<\/i> 322: 583-586.","DOI":"10.1126\/science.1156232"},{"key":"131","doi-asserted-by":"crossref","unstructured":"131. Bowers RR, Lane MD (2007) A role for bone morphogenetic protein-4 in adipocyte development.<i> Cell Cycle<\/i> 6: 385-389.","DOI":"10.4161\/cc.6.4.3804"},{"key":"132","doi-asserted-by":"crossref","unstructured":"132. Huang H, Song TJ, Li X, Hu L, He Q, et al. (2009) BMP signaling pathway is required for commitment of C3H10T1\/2 pluripotent stem cells to the adipocyte lineage.<i> Proc Natl Acad Sci U S A<\/i> 106: 12670-12675.","DOI":"10.1073\/pnas.0906266106"},{"key":"133","doi-asserted-by":"crossref","unstructured":"133. Tang QQ, Otto TC, Lane MD (2004) Commitment of C3H10T1\/2 pluripotent stem cells to the adipocyte lineage.<i> Proc Natl Acad Sci U S A<\/i> 101: 9607-9611.","DOI":"10.1073\/pnas.0403100101"},{"key":"134","doi-asserted-by":"crossref","unstructured":"134. Bowers RR, Kim JW, Otto TC, Lane MD (2006) Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.<i> Proc Natl Acad Sci U S A<\/i> 103: 13022-13027.","DOI":"10.1073\/pnas.0605789103"},{"key":"135","doi-asserted-by":"crossref","unstructured":"135. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, et al. (2000) Inhibition of adipogenesis by Wnt signaling.<i> Science<\/i> 289: 950-953.","DOI":"10.1126\/science.289.5481.950"},{"key":"136","doi-asserted-by":"crossref","unstructured":"136. Bowers RR, Lane MD (2008) Wnt signaling and adipocyte lineage commitment.<i> Cell Cycle<\/i> 7: 1191-1196.","DOI":"10.4161\/cc.7.9.5815"},{"key":"137","doi-asserted-by":"crossref","unstructured":"137. Davis LA, Zur Nieden NI (2008) Mesodermal fate decisions of a stem cell: the Wnt switch.<i> Cell Mol Life Sci<\/i> 65: 2658-2674.","DOI":"10.1007\/s00018-008-8042-1"},{"key":"138","doi-asserted-by":"crossref","unstructured":"138. Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, et al. (2007) Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT\/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma.<i> J Biol Chem<\/i> 282: 14515-14524.","DOI":"10.1074\/jbc.M700030200"},{"key":"139","doi-asserted-by":"crossref","unstructured":"139. Cousin W, Fontaine C, Dani C, Peraldi P (2007) Hedgehog and adipogenesis: fat and fiction.<i> Biochimie<\/i> 89: 1447-1453.","DOI":"10.1016\/j.biochi.2007.08.012"},{"key":"140","doi-asserted-by":"crossref","unstructured":"140. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, et al. (2008) Dynamics of fat cell turnover in humans.<i> Nature<\/i> 453: 783-787.","DOI":"10.1038\/nature06902"},{"key":"141","doi-asserted-by":"crossref","unstructured":"141. Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, et al. (2006) Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.<i> Dev Biol<\/i> 296: 164-176.","DOI":"10.1016\/j.ydbio.2006.04.449"},{"key":"142","doi-asserted-by":"crossref","unstructured":"142. Seale P, Bjork B, Yang W, Kajimura S, Chin S, et al. (2008) PRDM16 controls a brown fat\/skeletal muscle switch.<i> Nature<\/i> 454: 961-967.","DOI":"10.1038\/nature07182"},{"key":"143","doi-asserted-by":"crossref","unstructured":"143. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, et al. (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.<i> Nature<\/i> 454: 1000-1004.","DOI":"10.1038\/nature07221"},{"key":"144","doi-asserted-by":"crossref","unstructured":"144. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, et al. (2009) Initiation of myoblast to brown fat switch by a PRDM16-C\/EBP-beta transcriptional complex.<i> Nature<\/i> 460: 1154-1158.","DOI":"10.1038\/nature08262"},{"key":"145","doi-asserted-by":"crossref","unstructured":"145. Kajimura S, Seale P, Spiegelman BM (2010) Transcriptional control of brown fat development.<i> Cell Metab<\/i> 11: 257-262.","DOI":"10.1016\/j.cmet.2010.03.005"},{"key":"146","doi-asserted-by":"crossref","unstructured":"146. Fujikura J, Nakao K, Sone M, Noguchi M, Mori E, et al. (2012) Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation.<i> Diabetologia<\/i> 55: 1689-1698.","DOI":"10.1007\/s00125-012-2508-2"},{"key":"147","doi-asserted-by":"crossref","unstructured":"147. May-Panloup P, Chretien MF, Malthiery Y, Reynier P (2007) Mitochondrial DNA in the oocyte and the developing embryo.<i> Curr Top Dev Biol<\/i> 77: 51-83.","DOI":"10.1016\/S0070-2153(06)77003-X"},{"key":"148","doi-asserted-by":"crossref","unstructured":"148. Finsterer J (2009) Manifestations of the mitochondrial A3243G mutation.<i> Int J Cardiol<\/i> 137: 60-62.","DOI":"10.1016\/j.ijcard.2008.04.089"},{"key":"149","doi-asserted-by":"crossref","unstructured":"149. Sato M, Sato K (2011) Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos.<i> Science<\/i> 334: 1141-1144.","DOI":"10.1126\/science.1210333"},{"key":"150","doi-asserted-by":"crossref","unstructured":"150. Shoubridge EA, Wai T (2007) Mitochondrial DNA and the mammalian oocyte.<i> Curr Top Dev Biol<\/i> 77: 87-111.","DOI":"10.1016\/S0070-2153(06)77004-1"},{"key":"151","doi-asserted-by":"crossref","unstructured":"151. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, et al. (2008) Disease-specific induced pluripotent stem cells.<i> Cell<\/i> 134: 877-886.","DOI":"10.1016\/j.cell.2008.07.041"},{"key":"152","doi-asserted-by":"crossref","unstructured":"152. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, et al. (2009) Generation of pluripotent stem cells from patients with type 1 diabetes.<i> Proc Natl Acad Sci U S A<\/i> 106: 15768-15773.","DOI":"10.1073\/pnas.0906894106"},{"key":"153","doi-asserted-by":"crossref","unstructured":"153. Ohmine S, Squillace KA, Hartjes KA, Deeds MC, Armstrong AS, et al. (2012) Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency.<i> Aging (Albany NY)<\/i> 4: 60-73.","DOI":"10.18632\/aging.100428"},{"key":"154","doi-asserted-by":"crossref","unstructured":"154. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, et al. (2010) Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes.<i> Proc Natl Acad Sci U S A<\/i> 107: 17668-17673.","DOI":"10.1073\/pnas.1004487107"},{"key":"155","doi-asserted-by":"crossref","unstructured":"155. Rashid ST, Corbineau S, Hannan N, Marciniak SJ, Miranda E, et al. (2010) Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.<i> J Clin Invest<\/i> 120: 3127-3136.","DOI":"10.1172\/JCI43122"},{"key":"156","doi-asserted-by":"crossref","unstructured":"156. Cayo MA, Cai J, DeLaForest A, Noto FK, Nagaoka M, et al. (2012) JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia.<i> Hepatology<\/i> 56: 2163-2171.","DOI":"10.1002\/hep.25871"},{"key":"157","doi-asserted-by":"crossref","unstructured":"157. Jang J, Kang HC, Kim HS, Kim JY, Huh YJ, et al. (2011) Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.<i> Ann Neurol<\/i> 70: 402-409.","DOI":"10.1002\/ana.22486"},{"key":"158","doi-asserted-by":"crossref","unstructured":"158. Ghodsizadeh A, Taei A, Totonchi M, Seifinejad A, Gourabi H, et al. (2010) Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells.<i> Stem Cell Rev<\/i> 6: 622-632.","DOI":"10.1007\/s12015-010-9189-3"},{"key":"159","doi-asserted-by":"crossref","unstructured":"159. Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, et al. (2011) Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies.<i> Cell<\/i> 146: 37-52.","DOI":"10.1016\/j.cell.2011.06.001"},{"key":"160","doi-asserted-by":"crossref","unstructured":"160. Panicker LM, Miller D, Park TS, Patel B, Azevedo JL, et al. (2012) Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease.<i> Proc Natl Acad Sci U S A<\/i> 109: 18054-18059.","DOI":"10.1073\/pnas.1207889109"},{"key":"161","doi-asserted-by":"crossref","unstructured":"161. Zhang S, Chen S, Li W, Guo X, Zhao P, et al. (2011) Rescue of ATP7B function in hepatocyte-like cells from Wilson&rsquo;s disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.<i> Hum Mol Genet<\/i> 20: 3176-3187.","DOI":"10.1093\/hmg\/ddr223"},{"key":"162","doi-asserted-by":"crossref","unstructured":"162. Somers A, Jean JC, Sommer CA, Omari A, Ford CC, et al. (2010) Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.<i> Stem Cells<\/i> 28: 1728-1740.","DOI":"10.1002\/stem.495"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/60\/6\/60_EJ13-0162\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T01:53:46Z","timestamp":1645581226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/60\/6\/60_EJ13-0162\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":162,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej13-0162","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}