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Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. <i>Diabetologia<\/i> 46: 3-19.","DOI":"10.1007\/s00125-002-1009-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Fukushima M, Usami M, Ikeda M, <i>et al.<\/i> (2004) Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes.<i> Metabolism<\/i> 53: 831-835.","DOI":"10.1016\/j.metabol.2004.02.012"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Tanaka Y, Atsumi Y, Asahina, <i>et al.<\/i> (1998) Usefulness of Revised Fasting Plasma Glucose Criterion and Characteristics of the Insulin Response to an Oral Glucose Load in Newly Diagnosed Japanese Diabetic Subjects.<i> Diabetes Care<\/i> 21: 1133-1137.","DOI":"10.2337\/diacare.21.7.1133"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. 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Kadowaki T, Ohtani T, Odawara M (2012) Potential formula for the calculation of starting and incremental insulin glargine doses: ALOHA subanalysis. <i>PLoS One<\/i> 7: e41358.","DOI":"10.1371\/journal.pone.0041358"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Pennartz C, Schenker N, Menge BA, <i>et al.<\/i> (2011) Chronic reduction of fasting glycemia with insulin glargine improves first- and second-phase insulin secretion in patients with type 2 diabetes. <i>Diabetes Care<\/i> 34: 2048-2053.","DOI":"10.2337\/dc11-0471"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Pistrosch F, K&ouml;hler C, Schaper F, <i>et al.<\/i> (2013) Effects of insulin glargine versus metformin on glycemic variability, microvascular and beta-cell function in early type 2 diabetes. <i>Acta Diabetol<\/i> [Epub ahead of print]","DOI":"10.1007\/s00592-012-0451-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Forst T, Larbig M, Hohberg C, <i>et al.<\/i> (2010) Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes. <i>Diabetes Obes Metab<\/i> 12: 437-441.","DOI":"10.1111\/j.1463-1326.2010.01209.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Roden M, Price TB, Perseghin G, <i>et al.<\/i> (1996) Mechanism of free fatty acid-induced insulin resistance in humans.<i> J Clin Invest<\/i> 97: 2859-2865.","DOI":"10.1172\/JCI118742"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Paolisso G, Howard BV (1998) Role of non-esterified fatty acids in the pathogenesis of type 2 diabetes mellitus. <i>Diabet Med<\/i> 15: 360-366.","DOI":"10.1002\/(SICI)1096-9136(199805)15:5<360::AID-DIA568>3.0.CO;2-W"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. 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Jovanovic A, Gerrard J, Taylor R (2009) The second-meal phenomenon in type 2 diabetes. <i>Diabetes Care<\/i> 32: 1199-1201.","DOI":"10.2337\/dc08-2196"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. ORIGIN Trial Investigators (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. <i>N Engl J Med<\/i> 367: 319-328.","DOI":"10.1056\/NEJMoa1203858"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. 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