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Niswender K (2009) Early and aggressive initiation of insulin therapy for type 2 diabetes: What Is the evidence? Clin Diabetes<\/i> 27: 60-68.","DOI":"10.2337\/diaclin.27.2.60"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. U.K. Prospective Diabetes Study Group (1995) U.K. prospective diabetes study 16. Overview of 6 years’ therapy of type II diabetes: a progressive disease. Diabetes<\/i> 44: 1249-1258.","DOI":"10.2337\/diab.44.11.1249"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Defronzo RA (2009) Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes<\/i> 58: 773-795.","DOI":"10.2337\/db09-9028"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Festa A, Williams K, D’Agostino R Jr, Wagenknecht LE, Haffner SM (2006) The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. 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Gerich JE (2002) Is reduced first-phase insulinrelease the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes<\/i> 51: S117-121.","DOI":"10.2337\/diabetes.51.2007.S117"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Cerasi E, Luft R (1967) What is inherited? What is added? Hypothesis for the pathogenesis of diabetes mellitus. Diabetes<\/i> 16: 615-627.","DOI":"10.2337\/diab.16.9.615"},{"key":"39","unstructured":"39. Brunzell JD, Robertson RP, Lerner RL, Hazzard WR, Ensinck, at al. (1976). Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab<\/i> 42: 222-229."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Kahn CB, Soeldner JS, Gleason RE, Rojas L, Camerini-Davalos RA, et al. (1969) Clinical and chemical diabetes in the offspring of diabetic couples. 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