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In: Williams Textbook of Endocrinology (12<sup>th<\/sup>). Saunders, Collingwood: 479-577."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Asano T, Aoki A, Sasaki M, Ikoma A, Kakei M, et al. (2012) Hyponatremia is the valuable manifestation for initiating diagnosis of hypopituitarism in elderly. <i>Endocr J <\/i>59: 1015-1020.","DOI":"10.1507\/endocrj.EJ12-0067"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Diederich S, Franzen NF, B&auml;hr V, Oelkers W (2003) Severe hyponatremia due to hypopituitarism with adrenal insufficiency: report on 28 cases. <i>Eur J Endocrinol <\/i>148: 609-617.","DOI":"10.1530\/eje.0.1480609"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Chihara K, Shimatsu A, Hizuka N, Tanaka T, Seino Y, et al. (2007) A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency.<i> Eur J Endocrinol <\/i>157: 19-27.","DOI":"10.1530\/EJE-07-0066"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Arvat E, Maccagno B, Ramunni J, Di Vito L, Gianotti L, et al. (1998) Effect of dexamethasone and alprazolam, a benzodiazepine, on the stimulatory effect of hexarelin, a synthetic GHRP, on ACTH, cortisol and GH secretion in humans. <i>Neuroendocrinology<\/i> 67: 310-316.","DOI":"10.1159\/000054328"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Wren AM, Small CJ, Fribbens CV, Neary NM, Ward HL, et al. (2002) The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. <i>Neuroendocrinology<\/i> 76: 316-324.","DOI":"10.1159\/000066629"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Coiro V, Saccani-Jotti G, Minelli R, Melani A, Milli B, et al. (2005) Adrenocorticotropin\/cortisol and arginine-vasopressin secretory patterns in response to ghrelin in normal men. <i>Neuroendocrinology<\/i> 81: 103-106.","DOI":"10.1159\/000085541"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Korbonits M, Kaltsas G, Perry LA, Putignano P, Grossman AB, et al. (1999) The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. <i>J Clin Endocrinol Metab<\/i> 84: 2489-2495.","DOI":"10.1210\/jcem.84.7.5811"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hirotani C, Oki Y, Ukai K, Okuno T, Kurasaki S, et al. (2005) ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF. <i>Naunyn Schmiedebergs Arch Pharmacol<\/i> 371: 54-60.","DOI":"10.1007\/s00210-004-1009-3"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Arvat E, Maccagno B, Ramunni J, Di Vito L, Broglio F, et al. (1997) Hexarelin, a synthetic growth-hormone releasing peptide, shows no interaction with corticotropin-releasing hormone and vasopressin on adrenocorticotropin and cortisol secretion in humans. <i>Neuroendocrinology<\/i> 66: 432-438.","DOI":"10.1159\/000127269"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kamoi K, Minagawa S, Kimura K, Ishizawa M, Ohara N, et al. (2010) GH-releasing peptide-2 does not stimulate arginine vasopressin secretion in healthy men. <i>Endocr J <\/i>57: 175-180.","DOI":"10.1507\/endocrj.K09E-215"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kageyama K, Nigawara T, Sakihara S, Takayasu S, Terui K, et al. (2008) Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. <i>Endocr J<\/i> 55: 777-783.","DOI":"10.1507\/endocrj.K07E-168"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kano T, Sugihara H, Sudo M, Nagao M, Harada T, et al. (2009) Comparison of pituitary-adrenal responsiveness between insulin tolerance test and growth hormone-releasing peptide-2 test: a pilot study. <i>Peptides<\/i> 31: 657-661.","DOI":"10.1016\/j.peptides.2009.12.023"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kimura T, Shimatsu A, Arimura H, Mori H, Tokitou A, et al. (2010) Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamo-pituitary disorders: evidence for direct ACTH releasing activity of GHRP-2. <i>Endocr J<\/i> 57: 639-644.","DOI":"10.1507\/endocrj.K10E-017"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Arlt W, Allolio B (2003) Adrenal insufficiency. <i>Lancet<\/i> 361: 1881-1893.","DOI":"10.1016\/S0140-6736(03)13492-7"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Charmandari E, Nicolaides NC, Chrousos GP (2014) Adrenal insufficiency. <i>Lancet<\/i> 383: 2152-2167.","DOI":"10.1016\/S0140-6736(13)61684-0"},{"key":"20","unstructured":"20. Grinspoon SK, Biller BM (1994) Clinical review 62: Laboratory assessment of adrenal insufficiency. <i>J Clin Endocrinol Metab<\/i> 79: 923-931."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Grossman AB (2010) Clinical review: The diagnosis and management of central hypoadrenalism. <i>J Clin Endocrinol Metab<\/i> 95: 4855-4863.","DOI":"10.1210\/jc.2010-0982"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Schulte HM, Chrousos GP, Avgerinos P, Oldfield EH, Gold PW, et al. (1984) The corticotropin-releasing hormone stimulation test: a possible aid in the evaluation of patients with adrenal insufficiency. <i>J Clin Endocrinol Metab<\/i> 58: 1064-1067.","DOI":"10.1210\/jcem-58-6-1064"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Longui CA, Vottero A, Harris AG, Chrousos GP (1998) Plasma cortisol responses after intramuscular corticotropin 1-24 in healthy men. <i>Metabolism<\/i> 47: 1419-1422.","DOI":"10.1016\/S0026-0495(98)90316-X"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Galv&atilde;o-Teles A, Burke CW, Fraser TR (1971) Adrenal function tested with tetracosactrin depot. <i>Lancet<\/i> 1: 557-560.","DOI":"10.1016\/S0140-6736(71)91160-3"},{"key":"25","unstructured":"25. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM (2011) Hypothalamus and pituitary. In: Williams Textbook of Endocrinology (12<sup>th<\/sup>). Saunders, Collingwood: 115-156."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kageyama K, Hanada K, Iwasaki Y, Sakihara S, Nigawara T, et al. 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