{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:35:11Z","timestamp":1759937711758},"reference-count":26,"publisher":"Japan Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1507\/endocrj.ej16-0170","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T22:06:51Z","timestamp":1480630011000},"page":"221-227","source":"Crossref","is-referenced-by-count":17,"title":["Gradually increasing ethinyl estradiol for Turner syndrome may produce good final height but not ideal BMD"],"prefix":"10.1507","volume":"64","author":[{"given":"Yukihiro","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ariyasu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Izawa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Igaki-Miyamoto","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Fukuma","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Hatano","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Yagi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Tokyo Metropolitan Children&rsquo;s Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Turner HH (1938) A syndrome of infantilism, congenital webbed neck, and cubitus valgus. <i>Endocrinology<\/i> 23: 566-574.","DOI":"10.1210\/endo-23-5-566"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Gravholt CH (2004) Epidemiological, endocrine and metabolic features in Turner syndrome. <i>Eur J Endocrinol<\/i> 151: 657-687.","DOI":"10.1530\/eje.0.1510657"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bondy CA, Turner Syndrome Study Group (2007) Care of girls and women with Turner syndrome: a guideline of the Turner syndrome Study Group. <i>J Clin Endocrinol Metab<\/i> 92: 10-25.","DOI":"10.1210\/jc.2006-1374"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Sybert VP, McCauley E (2004) Turner&rsquo;s syndrome. <i>N Engl J Med<\/i> 351: 1227-1238.","DOI":"10.1056\/NEJMra030360"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Rosenfeld RG, Attie KM, Frane J, Brasel JA, Burstein S,<i> et al<\/i>. (1998) Growth hormone therapy of Turner&rsquo;s sundrome: Beneificial effect on adult height. <i>J Pediatr<\/i> 132: 319-324.","DOI":"10.1016\/S0022-3476(98)70452-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. van Pareren YK, de Muinck Keizer-Schrama SM, Stijnen T, Sas TC, Jansen M, <i>et al<\/i>. (2003) Final height in girls with turner syndrome after long-term growth hormone treatment in three dosages and low dose estrogens. <i>J Clin Endocrinol Metab <\/i>88: 1119-1125.","DOI":"10.1210\/jc.2002-021171"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Stephure DK; Canadian Growth Hormone Advisory Committee (2005) Impact of growth hormone supplementation on adult height in turner syndrome: results of the Canadian randomized controlled trial. <i>J Clin Endocrinol Metab<\/i> 90: 3360-3366.","DOI":"10.1210\/jc.2004-2187"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bettendorf M, Inta IM, Doerr HG, Hauffa BP, Mehls O, <i>et al<\/i>. (2013) Height gain in Ullrich-Turner syndrome after early and late growth hormone treatment start: results from a large retrospective German study and potential basis for an individualized treatment approach. <i>Horm Res Paediatr<\/i> 80: 356-362.","DOI":"10.1159\/000356045"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Wasniewska M, Aversa T, Mazzanti L, Guarneri MP, Matarazzo P, <i>et al<\/i>. (2013) Adult height in girls with Turner syndrome treated from before 6 years of age with a fixed per kilogram GH dose. <i>Eur J Endocrinol<\/i> 169: 439-443.","DOI":"10.1530\/EJE-12-1032"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Quigley CA, Wan X, Garg S, Kowal K, Cutler GB Jr, <i>et al<\/i>. (2014) Effects of low-dose estrogen replacement during childhood on pubertal development and gonadotropin concentrations in patients with Turner syndrome: results of a randomized, double-blind, placebo-controlled clinical trial. <i>J Clin Endocrinol Metab<\/i> 99: E1754-1764.","DOI":"10.1210\/jc.2013-4518"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ross JL, Quigley CA, Cao D, Feuillan P, Kowal K, <i>et al<\/i>. (2011) Growth hormone plus childhood low-dose estrogen in Turner&rsquo;s syndrome. <i>N Engl J Med<\/i> 364: 1230-1242.","DOI":"10.1056\/NEJMoa1005669"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Aso K, Koto S, Higuchi A, Ariyasu D, Izawa M, <i>et al<\/i>. (2010) Serum FSH level below 10 mIU\/mL at twelve years old is an index of spontaneous and cyclical menstruation in Turner syndrome. <i>Endo J <\/i>57: 909-913.","DOI":"10.1507\/endocrj.K10E-092"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Isojima T, Yokoya S, Ito J, Horikawa R, Tanaka T (2009) New reference growth charts for Japanese girls with Turner syndrome. <i>Pediatr Int<\/i> 51: 709-714.","DOI":"10.1111\/j.1442-200X.2009.02838.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kroeger H, Kotaniemi A, Vainio P, Alhava E (1992) Bone densitometry of the spine and femur in children by dual-energy x-ray absorption. <i>Bone Miner <\/i>17: 75-85.","DOI":"10.1016\/0169-6009(92)90712-M"},{"key":"15","unstructured":"15. Tanaka T, Igarashi Y, Ozono K, Oyama K, Ogawa M, <i>et al<\/i>. (2011) Efficacy of high dose growth hormone treatment in Turner syndrome: Seven-year experience of Turner syndrome Research Collaboration. <i>J of Japanese Association for Human Auxology<\/i> 17: 8-15 (In Japanese)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Tanaka T, Horikawa R, Tanae A, Hibi I (2000) Final Height in Girls with Turner Syndrome after Growth Hormone Treatment; Experience at National Children&rsquo;s Hospital. <i>Clin Pediatr Endocrinol<\/i> 9: 41-46.","DOI":"10.1297\/cpe.9.41"},{"key":"17","unstructured":"17. Mochizuki T, Fujita K, Yokoya S (2010) A Quetionnaire Survey of the Follow-up in Adults Turner Women in Japan. <i>J of Japanese Society for Pediatrics<\/i> 114: 43-47 (In Japanese)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Rongen-Westerlaken C, Corel L, van den Broeck J, Massa G, Karlberg J, <i>et al<\/i>. (1997) Reference values for height, height velocity and weight in Turner&rsquo;s syndrome. Swedish Study Group for GH treatment. <i>Acta Paediatr <\/i>86: 937-942.","DOI":"10.1111\/j.1651-2227.1997.tb15174.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Bulun SE (2014) Aromatase and Estrogen receptor &alpha; deficiency. <i>Fertil Steril<\/i> 101: 323-329.","DOI":"10.1016\/j.fertnstert.2013.12.022"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB Jr (1994) Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. <i>J Clin Invest<\/i> 94: 2475-2480.","DOI":"10.1172\/JCI117616"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nanao K, Tsuchiya Y, Kotoh S, Hasegawa Y (2002) Low vertebral cancellous bone density in peripubertal girls with Turner&rsquo;s syndrome and boys with hypogonadism. <i>J Pediatr Endocrinol Metab<\/i> 15: 1537-1542.","DOI":"10.1515\/JPEM.2002.15.9.1537"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Soucek O, Lebl J, Snajderova M, Kolouskova S, Rocek M, <i>et al<\/i>. (2011) Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages. <i>Clin Endocrinol (Oxf) <\/i>74: 445-452.","DOI":"10.1111\/j.1365-2265.2010.03955.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Aycan Z, Cetinkaya E, Darendeliler F, Vidinlisan S, Bas F, <i>et al<\/i>. (2008) The effect of growth hormone treatment on bone mineral density in prepubertal girls with Turner syndrome: a multicentre prospective clinical trial. <i>Clin Endocrinol (Oxf)<\/i> 68: 769-772.","DOI":"10.1111\/j.1365-2265.2007.03107.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Scarabin PY, Oger E, Plu-Bureau G, Estrogen, THromboEmbolism Risk Study Group (2003) Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. <i>Lancet<\/i> 362: 428-432.","DOI":"10.1016\/S0140-6736(03)14066-4"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, <i>et al<\/i>. (2007) Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study. <i>Circulation<\/i> 115: 840-845.","DOI":"10.1161\/CIRCULATIONAHA.106.642280"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ross JL, Cassorla F, Carpenter G, Long LM, Royster MS, <i>et al<\/i>. (1988) The effect of short term treatment with growth hormone and ethinyl estradiol on lower leg growth rate in girls with Turner&rsquo;s syndrome. <i>J Clin Endocrinol Metab<\/i> 67: 515-518.","DOI":"10.1210\/jcem-67-3-515"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/2\/64_EJ16-0170\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T05:04:41Z","timestamp":1498367081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/2\/64_EJ16-0170\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej16-0170","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}