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Rasmussen H, Zawalich KC, Ganesan S, Calle R, Zawalich WS (1990) Physiology and pathophysiology of insulin secretion. <i>Diabetes Care<\/i> 13: 655-666.","DOI":"10.2337\/diacare.13.6.655"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic &beta;-cells and hepatocytes. <i>Diabetes<\/i> 39: 647-652.","DOI":"10.2337\/diab.39.6.647"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Henquin JC (2009) Regulation of insulin secretion: a matter of phase control and amplitude modulation. <i>Diabetologia<\/i> 52: 739-751.","DOI":"10.1007\/s00125-009-1314-y"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dean PM, Matthews EK (1968) Electrical activity in pancreatic islet cells. <i>Nature<\/i> 219: 389-390.","DOI":"10.1038\/219389a0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cook DL, Hales CN (1984) Intracellular ATP directly blocks K<sup>+<\/sup>-channels in pancreatic B-cells. <i>Nature<\/i> 311: 271-273.","DOI":"10.1038\/311271a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Komatsu M, Takei M, Ishii H, Sato Y (2013) Glucose-stimulated insulin secretion: A newer perspective. <i>J Diabetes Investig<\/i> 4: 511-516.","DOI":"10.1111\/jdi.12094"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J, et al. (2015) Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic &beta;-cells. <i>J Diabetes Investig<\/i> 6: 256-263.","DOI":"10.1111\/jdi.12304"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kojima I, Nakagawa Y, Hamano K, Medina J, Li L, et al. (2015) Glucose-sensing receptor T1R3: A new signaling receptor activated by glucose in pancreatic &beta;-cells. <i>Biol Pharm Bull<\/i> 38: 674-679.","DOI":"10.1248\/bpb.b14-00895"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Nelson G, Hoon MA, Chandrasekar J, Zhang Y, Ryba NJP, et al. (2001) Mammalian sweet taste receptors. <i>Cell<\/i> 106: 381-390.","DOI":"10.1016\/S0092-8674(01)00451-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nakagawa Y, Ohtsu Y, Nagasawa M, Shibata H, Kojima I (2014) Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor. <i>Endocr J<\/i> 61: 119-131.","DOI":"10.1507\/endocrj.EJ13-0431"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Knight I (1994) The development and applications of sucralose, a new high-intensity sweetener. <i>Can J Physiol Pharmacol<\/i> 72: 435-439.","DOI":"10.1139\/y94-063"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, et al. (2009) Sweet taste receptor expressed in pancreatic &beta;-cells activates the calcium and cyclic AMP signaling system and stimulates insulin secretion. <i>PLoS One<\/i> 4: e5106.","DOI":"10.1371\/journal.pone.0005106"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nakagawa Y, Nagasawa M, Mogami H, Lohse MJ, Ninomiya Y, et al. (2013) Multimodal function of the sweet taste receptor expressed in pancreatic &beta;-cells: generation of diverse patterns of intracellular signals by sweet agonists. <i>Endocr J<\/i> 60: 1191-1206.","DOI":"10.1507\/endocrj.EJ13-0282"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, et al. (1990) Establishment of a pancreatic &beta;-cell line that retains glucose-inducible insulin secretion. <i>Endocrinology<\/i> 127: 126-132.","DOI":"10.1210\/endo-127-1-126"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nikolaev VO, B&uuml;nemann M, Hein L, Hannawacker A, Lohse MJ (2004) Novel single chain cAMP sensor for receptor-induced signal propagation. <i>J Biol Chem<\/i> 279: 37215-37218.","DOI":"10.1074\/jbc.C400302200"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pin JP, Galvez T, Pr&eacute;zeau L (2003) Evolution, structure and activation mechanism of family 3\/C G-protein-coupled receptors. <i>Pharmacol Ther<\/i> 98: 325-354.","DOI":"10.1016\/S0163-7258(03)00038-X"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, et al. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. <i>J Biol Chem<\/i> 280: 15238-15246.","DOI":"10.1074\/jbc.M414287200"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hamano K, Nakagawa Y, Ohtsu Y, Li LF, Medina J, Tanaka Y, et al. (2015) Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic &beta;-cells. <i>J Endocrinol<\/i> 226: 57-66.","DOI":"10.1530\/JOE-15-0102"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Suzuki Y, Zhang H, Saito N, Kojima I, Urano T, et al. (2006) Glucagon-like peptide 1 activates protein kinase C through Ca<sup>2+<\/sup>-dependent activation of phospholipase C in insulin-secreting cells. <i>J Biol Chem<\/i> 281: 28499-28507.","DOI":"10.1074\/jbc.M604291200"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Cussler EL, Evans DF, Matesich MA (1971) Theoretical and experimental basis for a specific counter transport system in membranes. <i>Science <\/i>172: 377-379.","DOI":"10.1126\/science.172.3981.377"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Li J, Shuai HY, Gylfe E, Tengholm A (2013) Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feed back from Ca(2+). <i>Diabetologia<\/i> 56: 1577-1586.","DOI":"10.1007\/s00125-013-2894-0"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. McCormack JG, Halestrap AP, Denton RM (1990) Role of calcium ions in regulation of mammalian intramitochondrial metabolism. <i>Physiol Rev<\/i> 70: 391-425.","DOI":"10.1152\/physrev.1990.70.2.391"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. McCormack JG, Longo EA, Corkey BE (1990) Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. <i>Biochem J<\/i> 267: 527-530.","DOI":"10.1042\/bj2670527"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Schutz JE, Klumpp S, Benz R, Sch&uuml;rhoff-Goeters WJ, Schmid A (1992) Regulation of adenylyl cyclase from paramecium by an intrinsic potassium conductance. <i>Science<\/i> 255: 600-603.","DOI":"10.1126\/science.1371017"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Zhang C, Zhou Z (2002) Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. <i>Nat Neurosci<\/i> 5: 425-430.","DOI":"10.1038\/nn845"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Murata Y, Iwasaki H, Sasaki M, Inaba K, Okamura Y (2005) Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. <i>Nature<\/i> 435: 1239-1243.","DOI":"10.1038\/nature03650"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. 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