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Rinella ME (2015) Nonalcoholic fatty liver disease: a systematic review. <i>JAMA<\/i> 313: 2263-2273."},{"key":"2","unstructured":"2. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, <i>et al<\/i>. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. <i>Hepatology<\/i> 55: 2005-2023."},{"key":"3","unstructured":"3. Demir M, Lang S, Steffen HM (2015) Nonalcoholic fatty liver disease: Current status and future directions. <i>J Dig Dis<\/i> 16: 541-557."},{"key":"4","unstructured":"4. Tilg H, Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. <i>Hepatology<\/i> 52: 1836-1846."},{"key":"5","unstructured":"5. Rolo AP, Teodoro JS, Palmeira CM (2012) Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. <i>Free Rad Biol Med<\/i> 52: 59-69."},{"key":"6","unstructured":"6. Yoon HJ, Cha BS (2014) Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease. <i>World J Hepatol<\/i> 6: 800-811."},{"key":"7","unstructured":"7. Du J, Zhang M, Lu J, Zhang X, Xiong Q, <i>et al<\/i>. (2016) Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK. <i>Endocrine<\/i> 53: 701-709."},{"key":"8","unstructured":"8. Qiang X, Xu L, Zhang M, Zhang P, Wang Y, <i>et al<\/i>. (2016) Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. <i>Biochem Biophys Res Commun<\/i> 472: 603-609."},{"key":"9","unstructured":"9. Qu LL, Yu B, Li Z, Jiang WX, Jiang JD, <i>et al<\/i>. (2016) Gastrodin ameliorates oxidative stress and proinflammatory response in nonalcoholic fatty liver disease through the AMPK\/Nrf2 pathway. <i>Phytother Res<\/i> 30: 402-411."},{"key":"10","unstructured":"10. Tang W, Jiang YF, Ponnusamy M, Diallo M (2014) Role of Nrf2 in chronic liver disease. <i>World J Gastroenterol<\/i> 20: 13079-13087."},{"key":"11","unstructured":"11. Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, <i>et al<\/i>. (2010) Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. <i>Free Radic Biol Med<\/i> 48: 357-371."},{"key":"12","unstructured":"12. Jimenez-Osorio AS, Gonzalez-Reyes S, Pedraza-Chaverri J (2015) Natural Nrf2 activators in diabetes. <i>Clin Chim Acta<\/i> 448: 182-192."},{"key":"13","unstructured":"13. Hamden K, Carreau S, Jamoussi K, Miladi S, Lajmi S, <i>et al<\/i>. (2009) 1Alpha,25 dihydroxyvitamin D3: therapeutic and preventive effects against oxidative stress, hepatic, pancreatic and renal injury in alloxan-induced diabetes in rats. <i>J Nutr Sci Vitaminol (Tokyo)<\/i> 55: 215-222."},{"key":"14","unstructured":"14. Foroozanfard F, Jamilian M, Bahmani F, Talaee R, Talaee N, <i>et al<\/i>. (2015) Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitamin D-deficient women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. <i>Clin Endocrinol (Oxf)<\/i> 83: 888-894."},{"key":"15","unstructured":"15. Bhat M, Ismail A (2015) Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. <i>J Steroid Biochem Mol Biol<\/i> 152: 171-179."},{"key":"16","unstructured":"16. Nakai K, Fujii H, Kono K, Goto S, Kitazawa R, <i>et al<\/i>. (2014) Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats. <i>Am J Hypertens<\/i> 27: 586-595."},{"key":"17","unstructured":"17. Wang H, Zhang Q, Chai Y, Liu Y, Li F, <i>et al<\/i>. (2015) 1,25(OH)D downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats. <i>J Endocrinol Invest <\/i>38: 1083-1091."},{"key":"18","unstructured":"18. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, <i>et al<\/i>. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. <i>Hepatology<\/i> 41: 1313-1321."},{"key":"19","unstructured":"19. Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ (2010) Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. <i>Drug Metab Dispos<\/i> 38: 2293-2301."},{"key":"20","unstructured":"20. Morrow JD (2005) Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. <i>Arterioscler Thromb Vasc Biol<\/i> 25: 279-286."},{"key":"21","unstructured":"21. Day CP, James OF (1998) Hepatic steatosis: innocent bystander or guilty party? <i>Hepatology<\/i> 27: 1463-1466."},{"key":"22","unstructured":"22. Peverill W, Powell LW, Skoien R (2014) Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation. <i>Int J Mol Sci<\/i> 15: 8591-8638."},{"key":"23","unstructured":"23. Nassir F, Ibdah JA (2014) Role of mitochondria in nonalcoholic fatty liver disease. <i>Int J Mol Sci<\/i> 15: 8713-8742."},{"key":"24","unstructured":"24. Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, <i>et al<\/i>. (2016) Vitamin D deficiency is associated with increased risk of non-alcoholic steatohepatitis in adults with non-alcoholic fatty liver disease: Possible role for MAPK and NF-kappaB? <i>Am J Gastroenterol<\/i> 111: 852-863."},{"key":"25","unstructured":"25. Chung GE, Kim D, Kwak MS, Yang JI, Yim JY, <i>et al<\/i>. (2016) The serum vitamin D level is inversely correlated with nonalcoholic fatty liver disease. <i>Clin Mol Hepatol<\/i> 22: 146-151."},{"key":"26","unstructured":"26. Zhai HL, Wang NJ, Han B, Li Q, Chen Y, <i>et al<\/i>. (2016) Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association in men in East China: a cross-sectional study (Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China)). <i>Br J Nutr<\/i> 115: 1352-1359."},{"key":"27","unstructured":"27. Nakano T, Cheng YF, Lai CY, Hsu LW, Chang YC, <i>et al<\/i>. (2011) Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. <i>J Hepatol<\/i> 55: 415-425."},{"key":"28","unstructured":"28. Yin Y, Yu Z, Xia M, Luo X, Lu X, <i>et al<\/i>. (2012) Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism. <i>Eur J Clin Invest<\/i> 42: 1189-1196."},{"key":"29","unstructured":"29. Sharifi N, Amani R, Hajiani E, Cheraghian B (2014) Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. <i>Endocrine<\/i> 47: 70-80."},{"key":"30","unstructured":"30. Husain K, Ferder L, Mizobuchi M, Finch J, Slatopolsky E (2009) Combination therapy with paricalcitol and enalapril ameliorates cardiac oxidative injury in uremic rats. <i>Am J Nephrol<\/i> 29: 465-472."},{"key":"31","unstructured":"31. Deng X, Cheng J, Shen M (2016) Vitamin D improves diabetic nephropathy in rats by inhibiting renin and relieving oxidative stress. <i>J Endocrinol Invest<\/i> 39: 657-666."},{"key":"32","unstructured":"32. Kim CS, Kwon Y, Choe SY, Hong SM, Yoo H, <i>et al<\/i>. (2015) Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1. <i>Nutr Metab (Lond) <\/i>12: 33."},{"key":"33","unstructured":"33. Karaman YK, Bivalkevich NV, Novgorodtseva TP, Gvozdenko TA (2013) Characteristics of heme oxygenase-1 expression in rat hepatocytes during the development of nonalcoholic steatohepatitis.<i> Bull Exp Biol Med <\/i>154: 431-434."},{"key":"34","unstructured":"34. Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, <i>et al<\/i>. (2014) Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. <i>Mol Cell Biol<\/i> 34: 3305-3320."},{"key":"35","unstructured":"35. Valdecantos MP, Prieto-Hontoria PL, Pardo V, M&oacute;dol T, Santamar&Iacute;a B, <i>et al<\/i>. (2015) Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. <i>Free Radic Biol Med<\/i> 84: 263-278."}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/7\/64_EJ16-0542\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T05:01:28Z","timestamp":1501304488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/7\/64_EJ16-0542\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej16-0542","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}