{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:38:58Z","timestamp":1789227538145,"version":"build-2803163510"},"reference-count":31,"publisher":"Japan Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1507\/endocrj.ej16-0548","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T22:09:34Z","timestamp":1482185374000},"page":"1-6","source":"Crossref","is-referenced-by-count":49,"title":["Assessment criteria for vitamin D deficiency\/insufficiency in Japan &amp;mdash; proposal by an expert panel supported by Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society [Opinion]"],"prefix":"10.1507","volume":"64","author":[{"given":"Ryo","family":"Okazaki","sequence":"first","affiliation":[{"name":"Third Department of Medicine, Teikyo University Chiba Medical Center, Ichihara 299-0111, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Teikyo University Chiba Medical Center, Ichihara 299-0111, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Minagawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chiba Children&rsquo;s Hospital, Chiba 266-0007, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Michigami","sequence":"additional","affiliation":[{"name":"Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi 594-1101, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Toranomon Hospital Endocrine Center, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitsugu","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, <i>et al<\/i>. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. <i>J Clin Endocrinol Metab<\/i> 96: 1911-1930.","DOI":"10.1210\/jc.2011-0385"},{"key":"2","unstructured":"2. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium (2011) Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington, DC."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, <i>et al<\/i>. (2010) IOF position statement: vitamin D recommendations for older adults. <i>Osteoporos Int<\/i> 21: 1151-1154.","DOI":"10.1007\/s00198-010-1285-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, <i>et al<\/i>. (2010) Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. <i>CMAJ <\/i>182: E610-618.","DOI":"10.1503\/cmaj.080663"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, <i>et al<\/i>. (2014) Clinician&rsquo;s Guide to Prevention and Treatment of Osteoporosis. <i>Osteoporos Int<\/i> 25: 2359-2381.","DOI":"10.1007\/s00198-014-2794-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, <i>et al<\/i>. (2016) Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. <i>J Clin Endocrinol Metab<\/i> 101: 394-415.","DOI":"10.1210\/jc.2015-2175"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. van Driel M, van Leeuwen JP (2014) Vitamin D endocrine system and osteoblasts. <i>Bonekey Rep<\/i> 3: 493.","DOI":"10.1038\/bonekey.2013.227"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. van der Meijden K, van Essen HW, Bloemers FW, Schulten EA, Lips P, <i>et al<\/i>. (2016) Regulation of CYP27B1 mRNA Expression in Primary Human Osteoblasts. <i>Calcif Tissue Int<\/i> 99: 164-173.","DOI":"10.1007\/s00223-016-0131-9"},{"key":"9","unstructured":"9. Segersten U, Correa P, Hewison M, Hellman P, Dralle H, <i>et al<\/i>. (2002) 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. <i>J Clin Endocrinol Metab<\/i> 87: 2967-2972."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ritter CS, Haughey BH, Armbrecht HJ, Brown AJ (2012) Distribution and regulation of the 25-hydroxyvitamin D3 1alpha-hydroxylase in human parathyroid glands. <i>J Steroid Biochem Mol Biol<\/i> 130: 73-80.","DOI":"10.1016\/j.jsbmb.2012.01.010"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sakuma M, Endo N, Oinuma T, Hayami T, Endo E, <i>et al<\/i>. (2006) Vitamin D and intact PTH status in patients with hip fracture. <i>Osteoporos Int<\/i> 17: 1608-1614.","DOI":"10.1007\/s00198-006-0167-1"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Sakuma M, Endo N, Hagino H, Harada A, Matsui Y, <i>et al<\/i>. (2011) Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan. <i>J Orthop Sci<\/i> 16: 418-423.","DOI":"10.1007\/s00776-011-0089-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ikegami S, Kamimura M, Uchiyama S, Kato H (2011) Women with insufficient 25-hydroxyvitamin D without secondary hyperparathyroidism have altered bone turnover and greater incidence of vertebral fractures. <i>J Orthop Sci<\/i> 16: 573-580.","DOI":"10.1007\/s00776-011-0107-6"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Yamauchi M, Kaji H, Nawata K, Takaoka S, Yamaguchi T, <i>et al<\/i>. (2011) Role of parathyroid hormone in bone fragility of postmenopausal women with vitamin D insufficiency. <i>Calcif Tissue Int<\/i> 88: 362-369.","DOI":"10.1007\/s00223-011-9464-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nakamura K, Saito T, Oyama M, Oshiki R, Kobayashi R, <i>et al<\/i>. (2011) Vitamin D sufficiency is associated with low incidence of limb and vertebral fractures in community-dwelling elderly Japanese women: the Muramatsu Study. <i>Osteoporos Int<\/i> 22: 97-103.","DOI":"10.1007\/s00198-010-1213-6"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Tanaka S, Kuroda T, Yamazaki Y, Shiraki Y, Yoshimura N, <i>et al<\/i>. (2014) Serum 25-hydroxyvitamin D below 25 ng\/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women. <i>J Bone Miner Metab<\/i> 32: 514-523.","DOI":"10.1007\/s00774-013-0520-3"},{"key":"17","unstructured":"17. Tamaki J, Iki M, Sato H, Kajita E, Nishino O, <i>et al<\/i>. (2015) Low serum 25(OH)D level increases fracture risk: the Japanese Population-based Osteoporosis (JPOS) cohort study. Dai 33-Kai Nihon Kotsutaisha Gakkai Gakujyutsu Shukai Programu Shoroku Shu (Program of the 33rd Meeting of the Japanese Society for Bone and Mineral Research) A177 (Abstract) (In Japanese)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Nakamura K, Tsugawa N, Saito T, Ishikawa M, Tsuchiya Y, <i>et al<\/i>. (2008) Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. <i>Bone<\/i> 42: 271-277.","DOI":"10.1016\/j.bone.2007.09.056"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tsugawa N, Uenishi K, Ishida H, Ozaki R, Takase T, <i>et al<\/i>. (2016) Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency. <i>J Bone Miner Metab<\/i> 34: 464-474.","DOI":"10.1007\/s00774-015-0694-y"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Okazaki R, Sugimoto T, Kaji H, Fujii Y, Shiraki M, <i>et al<\/i>. (2011) Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D(3) load in Japanese subjects. <i>J Bone Miner Metab<\/i> 29: 103-110.","DOI":"10.1007\/s00774-010-0200-5"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, <i>et al<\/i>. (2013) Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study. <i>Osteoporos Int<\/i> 24: 2775-2787.","DOI":"10.1007\/s00198-013-2372-z"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Suzuki T, Kwon J, Kim H, Shimada H, Yoshida Y, <i>et al<\/i>. (2008) Low serum 25-hydroxyvitamin D levels associated with falls among Japanese community-dwelling elderly. <i>J Bone Miner Res<\/i> 23: 1309-1317.","DOI":"10.1359\/jbmr.080328"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Shimizu Y, Kim H, Yoshida H, Shimada H, Suzuki T (2015) Serum 25-hydroxyvitamin D level and risk of falls in Japanese community-dwelling elderly women: a 1-year follow-up study. <i>Osteoporos Int<\/i> 26: 2185-2192.","DOI":"10.1007\/s00198-015-3130-1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ishijima M, Sakamoto Y, Yamanaka M, Tokita A, Kitahara K,<i> et al<\/i>. (2009) Minimum required vitamin D level for optimal increase in bone mineral density with alendronate treatment in osteoporotic women. <i>Calcif Tissue Int<\/i> 85: 398-404.","DOI":"10.1007\/s00223-009-9295-x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Adami S, Giannini S, Bianchi G, Sinigaglia L, Di Munno O, <i>et al<\/i>. (2009) Vitamin D status and response to treatment in post-menopausal osteoporosis. <i>Osteoporos Int<\/i> 20: 239-244.","DOI":"10.1007\/s00198-008-0650-y"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Carmel AS, Shieh A, Bang H, Bockman RS (2012) The 25(OH)D level needed to maintain a favorable bisphosphonate response is &ge;33 ng\/ml. <i>Osteoporos Int<\/i> 23: 2479-2487.","DOI":"10.1007\/s00198-011-1868-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Diez-Perez A, Olmos JM, Nogues X, Sosa M, Diaz-Curiel M, <i>et al<\/i>. (2012) Risk factors for prediction of inadequate response to antiresorptives. <i>J Bone Miner Res<\/i> 27: 817-824.","DOI":"10.1002\/jbmr.1496"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Peris P, Martinez-Ferrer A, Monegal A, Martinez de Osaba MJ, Muxi A, <i>et al<\/i>. (2012) 25 hydroxyvitamin D serum levels influence adequate response to bisphosphonate treatment in postmenopausal osteoporosis. <i>Bone<\/i> 51: 54-58.","DOI":"10.1016\/j.bone.2012.03.026"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fukumoto S, Ozono K, Michigami T, Minagawa M, Okazaki R, <i>et al<\/i>. (2015) Pathogenesis and diagnostic criteria for rickets and osteomalacia - proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society. <i>Endocr J<\/i> 62: 665-671.","DOI":"10.1507\/endocrj.EJ15-0289"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, <i>et al<\/i>. (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. <i>J Bone Miner Res<\/i> 25: 305-312.","DOI":"10.1359\/jbmr.090728"},{"key":"31","unstructured":"31. The Japan Endocrine Society. The Guide for the Differential Diagnosis of Hypocalcemia. http:\/\/endocrine.umin.ac.jp\/tebiki\/003\/003001.pdf (In Japanese)."}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/1\/64_EJ16-0548\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T06:18:37Z","timestamp":1498371517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/64\/1\/64_EJ16-0548\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej16-0548","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}