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Points that need more investigation. Hell J Nucl Med 20: 51\u201356."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Orgiazzi J (2012) Thyroid autoimmunity. Presse Med 41: e611\u2013e625.","DOI":"10.1016\/j.lpm.2012.10.002"},{"key":"3","unstructured":"3 Weetman A, DeGroot LJ (2016) Autoimmunity to the thyroid gland. www.thyroidmanager.org. Accessed jan 10<sup>th<\/sup> 2018."},{"key":"4","unstructured":"4 Bindra A, Braunstein G (2006) Thyroiditis. Am Fam Physician 73: 1769\u20131776."},{"key":"5","unstructured":"5 So M, Macisaac RJ, Grossman M (2012) Hypothyroidism. Aust Fam Physician 41: 556\u2013562."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Zantut-Wittmann DE, Persoli L, Tambascia MA, Fischer E, Franco Maldonado D, et al. (2004) HLA-DRB1*04 and HLA-DQB1*03 association with the atrophic but not with the goitrous form of chronic autoimmune thyroiditis in a Brazilian population. Horm Metab Res 36: 492\u2013500.","DOI":"10.1055\/s-2004-825732"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Zha B, Huang X, Lin J, Liu J, Hou Y, et al. (2014) Distribution of lymphocyte subpopulations in thyroid glands of human autoimmune thyroid disease. J Clin Lab Anal 28: 249\u2013254.","DOI":"10.1002\/jcla.21674"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Li D, Cai W, Gu R, Zhang Y, Zhang H, et al. (2013) Th17 cell plays a role in the pathogenesis of Hashimoto\u2019s thyroiditis in patients. Clin Immunol 149: 411\u2013420.","DOI":"10.1016\/j.clim.2013.10.001"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Colotta F, Jansson B, Bonelli F (2017) Modulation of inflammatory and immune responses by vitamin D. J Autoimmun 85: 78\u201397.","DOI":"10.1016\/j.jaut.2017.07.007"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10 Phenekos C, Vryonidou A, Gritzapis AD, Baxevanis CN, Goula M, et al. (2004) Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto\u2019s thyroiditis (Th1) and Graves\u2019 disease (Th2). Neuroimmunomodulation 11: 209\u2013213.","DOI":"10.1159\/000078438"},{"key":"11","unstructured":"11 Mazokopakis E, Kotsiris D (2014) Hashimoto\u2019s autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell J Nucl Med 17: 37\u201340."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Tamer G, Arik S, Tamer I, Coksert D (2011) Relative vitamin D insufficiency in Hashimoto\u2019s thyroiditis. Thyroid 21: 891\u2013896.","DOI":"10.1089\/thy.2009.0200"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Effraimidis G, Wiersinga WM (2014) Autoimmune thyroid disease: old and new players. Eur J Endocrinol 170: R241\u2013R252.","DOI":"10.1530\/EJE-14-0047"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Proal AD, Albert PJ, Marshall TG (2009) Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women. Ann N Y Acad Sci 1173: 252\u2013259.","DOI":"10.1111\/j.1749-6632.2009.04672.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Perricone C, Agmon-Levin N, Shoenfeld Y (2013) Novel pebbles in the mosaic of autoimmunity. BMC Med 11: 101.","DOI":"10.1186\/1741-7015-11-101"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Choi YM, Kim WG, Kim TY, Bae SJ, Kim HK, et al. (2014) Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 24: 655\u2013661.","DOI":"10.1089\/thy.2013.0460"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Ma J, Wu D, Li C, Fan C, Chao N, et al. (2015) Lower serum 25-hydroxyvitamin D level is associated with 3 types of autoimmune thyroid diseases. Medicine (Baltimore) 94: e1639.","DOI":"10.1097\/MD.0000000000001639"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Yang CY, Leung PS, Adamopoulos IE, Gershwin ME (2013) The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol 45: 217\u2013226.","DOI":"10.1007\/s12016-013-8361-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96: 1911\u20131930.","DOI":"10.1210\/jc.2011-0385"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Lin WY, Wan L, Tsai CH, Chen RH, Lee CC, et al. (2006) Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto\u2019s thyroiditis in Chinese pacients in Taiwan. J Clin Lab Anal 20: 109\u2013112.","DOI":"10.1002\/jcla.20110"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Unal AD, Tarcin O, Parildar H, Cigerli O, Eroglu H, et al. (2014) Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Cent Eur J Immunol 39: 493\u2013497.","DOI":"10.5114\/ceji.2014.47735"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Ferreira CES, Maeda SS, Batista MC, Lazaretti-Castro M, Vasconcellos LS, et al. (2017) Official positioning of the Brazilian Society of Clinical Pathology\/Laboratory Medicine (SBPC\/ML) and the Brazilian Society of Endocrinology and Metabolism (SBEM)\u2014Reference Intervals of Vitamin D\u201425(OH)D. 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(2014) Association of high vitamin D status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int J Endocrinol 2014: 631819.","DOI":"10.1155\/2014\/631819"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, et al. (2013) The association between severity of vitamin D deficiency and Hashimoto\u2019s thyroiditis. Endocr Pract 19: 479\u2013484.","DOI":"10.4158\/EP12376.OR"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Ke W, Sun T, Zhang Y, He L, Wu Q, et al. (2017) 25-Hydroxyvitamin D serum level in Hashimoto\u2019s thyroiditis but not Graves\u2019 disease is relatively deficient. Endocr J 64: 581\u2013587.","DOI":"10.1507\/endocrj.EJ16-0547"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Mansournia N, Mansournia MA, Saeedi S, Dehghan J (2014) The association between serum 25OHD levels and hypothyroid Hashimoto\u2019s thyroiditis. 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(2002) A polymorphism within the vitamin D-binding protein gene is associated with Grave\u2019s disease but not with Hashimoto\u2019s thyroiditis. J Clin Endocrinol Metab 87: 2564\u20132567."},{"key":"44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/thy.2000.10.475","volume":"10","author":"Y Ban","year":"2000","unstructured":"45 Ban Y, Ban Y, Taniyama M, Katagiri T (2000) Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves\u2019 disease. Thyroid 10: 475\u2013480.","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"45","doi-asserted-by":"crossref","unstructured":"46 Ban Y, Taniyama M, Ban Y (2001) Vitamin D receptor gene polymorphisms in Hashimoto\u2019s thyroiditis. 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