{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:16:52Z","timestamp":1788279412308,"version":"build-2803163510"},"reference-count":12,"publisher":"Japan Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1507\/endocrj.ej19-0063","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T22:08:14Z","timestamp":1559340494000},"page":"763-768","source":"Crossref","is-referenced-by-count":10,"title":["The association between thyroid hormone balance and thyroid volume in patients with Hashimoto thyroiditis"],"prefix":"10.1507","volume":"66","author":[{"given":"Motoki","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Ito","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirosuke","family":"Danno","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kousaka","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waka","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijun","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Fukata","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsushige","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaoki","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Internal Medicine II, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Laurberg P (1984) Mechanisms governing the relative proportions of thyroxine and 3,5,3&apos;-triiodothyronine in thyroid secretion. Metabolism 33: 379\u2013392.","DOI":"10.1016\/0026-0495(84)90203-8"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23: 38\u201389.","DOI":"10.1210\/edrv.23.1.0455"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, et al. (2007) Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased type 2 iodothyronine deiodinase activity. J Clin Endocrinol Metab 92: 1451\u20131457.","DOI":"10.1210\/jc.2006-1242"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Celi FS, Coppotelli G, Chidakel A, Kelly M, Brillante BA, et al. (2008) The role of type 1 and type 2 5&apos;-deiodinase in the pathophysiology of the 3,5,3&apos;-triiodothyronine toxicosis of McCune-Albright syndrome. J Clin Endocrinol Metab 93: 2383\u20132389.","DOI":"10.1210\/jc.2007-2237"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Ito M, Toyoda N, Nomura E, Takamura Y, Amino N, et al. (2011) Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3&apos;-triiodothyronine-predominant Graves\u2019 disease. Eur J Endocrinol 164: 95\u2013100.","DOI":"10.1530\/EJE-10-0736"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Ito M, Miyauchi A, Morita S, Kudo T, Nishihara E, et al. (2012) TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. Eur J Endocrinol 167: 373\u2013378.","DOI":"10.1530\/EJE-11-1029"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Harada A, Ito M, Miyauchi A, Nishikawa M, Toyoda N, <i>et al.<\/i> (2019) Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with huge goitrous Hashimoto thyroiditis. <i>Endocrine<\/i> in press.","DOI":"10.1007\/s12020-019-01855-7"},{"key":"8","unstructured":"8 Murakami Y, Takamatsu J, Sakane S, Kuma K, Ohsawa N (1996) Changes in thyroid volume in response to radioactive iodine for Graves\u2019 hyperthyroidism correlated with activity of thyroid-stimulating antibody and treatment outcome. J Clin Endocrinol Metab 81: 3257\u20133260."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR (2005) Type 2 iodothyronine deiodinase is the major source of plasma T<sub>3<\/sub> in euthyroid humans. J Clin Invest 115: 2524\u20132533.","DOI":"10.1172\/JCI25083"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Gereben B, Goncalves C, Harney JW, Larsen PR, Bianco AC (2000) Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol 14: 1697\u20131708.","DOI":"10.1210\/mend.14.11.0558"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Brtko J, Bob\u00e1lov\u00e1 J, Podoba J, Schmutzler C, K\u00f6hrle J (2002) Thyroid hormone receptors and type I iodothyronine 5&apos;-deiodinase activity of human thyroid toxic adenomas and benign cold nodules. Exp Clin Endocrinol Diabetes 110: 166\u2013170.","DOI":"10.1055\/s-2002-32147"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12 Murakami M, Araki O, Hosoi Y, Kamiya Y, Morimura T, et al. (2001) Expression and regulation of type II iodothyronine deiodinase in human thyroid gland. Endocrinology 142: 2961\u20132967.","DOI":"10.1210\/en.142.7.2961"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/66\/9\/66_EJ19-0063\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T03:51:24Z","timestamp":1569642684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/66\/9\/66_EJ19-0063\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej19-0063","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}