{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:52:32Z","timestamp":1778968352174,"version":"3.51.4"},"reference-count":14,"publisher":"Japan Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1507\/endocrj.ej20-0251","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T22:07:16Z","timestamp":1600380436000},"page":"163-170","source":"Crossref","is-referenced-by-count":2,"title":["Differential effects of \u03b2-arrestin1 and \u03b2-arrestin2 on somatostatin receptors in murine AtT-20 corticotroph tumor cells"],"prefix":"10.1507","volume":"68","author":[{"given":"Kazunori","family":"Kageyama","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Niioka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Takayasu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Daimon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Gadelha MR, Wildemberg LE, Bronstein MD, Gatto F, Ferone D (2017) Somatostatin receptor ligands in the treatment of acromegaly. Pituitary 20: 100\u2013108.","DOI":"10.1007\/s11102-017-0791-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Bruns C, Lewis I, Briner U, Meno-Tetang G, Weckbecker G (2002) SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur J Endocrinol 146: 707\u2013716.","DOI":"10.1530\/eje.0.1460707"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Hofland LJ, van der Hoek J, Feelders R, van Aken MO, van Koetsveld PM, et al. (2005) The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas <i>via<\/i> somatostatin receptor type 5. Eur J Endocrinol 152: 645\u2013654.","DOI":"10.1530\/eje.1.01876"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Hofland LJ (2008) Somatostatin and somatostatin receptors in Cushing\u2019s disease. Mol Cell Endocrinol 286: 199\u2013205.","DOI":"10.1016\/j.mce.2007.10.015"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Feelders RA, de Bruin C, Pereira AM, Romijn JA, Netea-Maier RT, et al. (2010) Lamberts, Pasireotide alone or with cabergoline and ketoconazole in Cushing\u2019s disease. N Engl J Med 362: 1846\u20131848.","DOI":"10.1056\/NEJMc1000094"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6 Gatto F, Feelders R, van der Pas R, Kros JM, Dogan F, et al. (2013) \u03b2-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly. Endocrinology 154: 4715\u20134725.","DOI":"10.1210\/en.2013-1672"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Cuevas-Ramos D, Fleseriu M (2014) Somatostatin receptor ligands and resistance to treatment in pituitary adenomas. J Mol Endocrinol v52: R223\u2013R240.","DOI":"10.1530\/JME-14-0011"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Gatto F, Biermasz NR, Feelders RA, Kros JM, Dogan F, et al. (2016) Low beta-arrestin expression correlates with the responsiveness to long-term somatostatin analog treatment in acromegaly. Eur J Endocrinol 174: 651\u2013662.","DOI":"10.1530\/EJE-15-0391"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Ishigame N, Kageyama K, Takayasu S, Furumai K, Nakada Y, et al. (2016) Regulation of the expression of corticotropin-releasing factor gene by pyroglutamylated RFamide peptide in rat hypothalamic 4B cells. Endocr J 63: 919\u2013927.","DOI":"10.1507\/endocrj.EJ16-0172"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Murasawa S, Kageyama K, Sugiyama A, Ishigame N, Niioka K, et al. (2014) Inhibitory effects of SOM230 on adrenocorticotropic hormone production and corticotroph tumor cell proliferation <i>in vitro<\/i> and <i>in vivo<\/i>. Mol Cell Endocrinol 394: 37\u201346.","DOI":"10.1016\/j.mce.2014.07.001"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Eigler T, Ben-Shlomo A (2014) Somatostatin system: molecular mechanisms regulating anterior pituitary hormones. J Mol Endocrinol 53: R1\u2013R19.","DOI":"10.1530\/JME-14-0034"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Moriyama T, Kageyama K, Kasagi Y, Iwasaki Y, Nigawara T, et al. (2005) Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA <i>via<\/i> protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells. Mol Cell Endocrinol 243: 74\u201379.","DOI":"10.1016\/j.mce.2005.09.010"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Roosterman D, Brune NE, Kreuzer OJ, Feld M, Pauser S, et al. (2008) Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells. FEBS J 275: 4728\u20134739.","DOI":"10.1111\/j.1742-4658.2008.06606.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, et al. (2018) \u03b2-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. PLoS One 13: e0196946.","DOI":"10.1371\/journal.pone.0196946"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/68\/2\/68_EJ20-0251\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T03:26:07Z","timestamp":1615001167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/68\/2\/68_EJ20-0251\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej20-0251","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}