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(2013) National incidence and prevalence of TSH-secreting pituitary adenomas in Sweden. J Clin Endocrinol Metab 98: 626\u2013635.","DOI":"10.1210\/jc.2012-3362"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD (1996) Thyrotropin-secreting pituitary tumors. 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Eur Thyroid J 2: 76\u201382.","DOI":"10.1159\/000351007"},{"key":"5","unstructured":"5 Japan Thyroid Association and the Japan Endocrine Society (ed) (2017) Guidelines for management of thyroid storm. Nankodo, Tokyo, Japan (In Japanese)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Fujio S, Ashari, Habu M, Yamahata H, Moinuddin FM, et al. (2014) Thyroid storm induced by TSH-secreting pituitary adenoma: a case report. Endocr J 61: 1131\u20131136.","DOI":"10.1507\/endocrj.EJ14-0278"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Page KA, Roehmholdt BF, Jablonski M, Mayerson AB (2008) Development of thyroid storm after surgical resection of a thyrotropin-secreting pituitary adenoma. Endocr Pract 14: 732\u2013737.","DOI":"10.4158\/EP.14.6.732"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Kuhn JM, Arlot S, Lefebvre H, Caron P, Cortet-Rudelli C, et al. (2000) Evaluation of the treatment of thyrotropin-secreting pituitary adenomas with a slow release formulation of the somatostatin analog lanreotide. J Clin Endocrinol Metab 85: 1487\u20131491.","DOI":"10.1210\/jcem.85.4.6548"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Gancel A, Vuillermet P, Legrand A, Catus F, Thomas F, et al. (1994) Effects of a slow-release formulation of the new somatostatin analogue lanreotide in TSH-secreting pituitary adenomas. Clin Endocrinol (Oxf) 40: 421\u2013428.","DOI":"10.1111\/j.1365-2265.1994.tb03941.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Caron P, Arlot S, Bauters C, Chanson P, Kuhn JM, et al. (2001) Efficacy of the long-acting octreotide formulation (octreotide-LAR) in patients with thyrotropin-secreting pituitary adenomas. J Clin Endocrinol Metab 86: 2849\u20132853.","DOI":"10.1210\/jcem.86.6.7593"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Shimatsu A, Murabe H, Kamoi K, Suzuki Y, Nakao K (1999) Treatment of thyrotropin-secreting pituitary adenomas with octreotide. Endocr J 46: 113\u2013123.","DOI":"10.1507\/endocrj.46.113"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Yamada S, Fukuhara N, Horiguchi K, Yamaguchi-Okada M, Nishioka H, et al. (2014) Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases. J Neurosurg 121: 1462\u20131473.","DOI":"10.3171\/2014.7.JNS1471"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Fukuhara N, Horiguchi K, Nishioka H, Suzuki H, Takeshita A, et al. (2015) Short-term preoperative octreotide treatment for TSH-secreting pituitary adenoma. 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(2007) Somatostatin receptor subtypes mRNA in TSH-secreting pituitary adenomas: a case showing a dramatic reduction in tumor size during short octreotide treatment. Endocr J 54: 371\u2013378.","DOI":"10.1507\/endocrj.K06-177"},{"key":"18","unstructured":"18 Somatuline LA [package insert]. Berkshire, UK: Ipsen Limited; 2019. https:\/\/www.medicines.org.uk\/emc\/product\/965\/smpc#gref accessed on January 19, 2021."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Shimatsu A, Teramoto A, Hizuka N, Kitai K, Ramis J, et al. (2013) Efficacy, safety, and pharmacokinetics of sustained-release lanreotide (lanreotide Autogel) in Japanese patients with acromegaly or pituitary gigantism. Endocr J 60: 651\u2013663.","DOI":"10.1507\/endocrj.EJ12-0417"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Wolin EM, Manon A, Chassaing C, Lewis A, Bertocchi L, et al. (2016) Lanreotide depot: an antineoplastic treatment of carcinoid or neuroendocrine tumors. J Gastrointest Cancer 47: 366\u2013374.","DOI":"10.1007\/s12029-016-9866-9"},{"key":"21","unstructured":"21 Somatuline AutoSolution [package insert]. Hoofddorp, The Netherlands: IPSEN FARMACEUTICA B.V; 2019. https:\/\/www.geneesmiddeleninformatiebank.nl\/smpc\/h26301_smpc.pdf accessed on January 19, 2021 (In Dutch)."},{"key":"22","unstructured":"22 Somatuline [package insert]. Tokyo, Japan: Teijin Pharma Limited; 2020. https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/470310_2499413G1025_1_07 accessed on January 19, 2021 (In Japanese)."},{"key":"23","unstructured":"23 (2010) Research group of \u201cHypothalamic-pituitary dysfunction,\u201d Research program of intractable disease, Health and Labour Sciences Grants from the Ministry of Health, Labour and Welfare ed. 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Introductory Guide MedDRA Version 22.0. https:\/\/admin.new.meddra.org\/sites\/default\/files\/guidance\/file\/intguide_22_0_english.pdf accessed on January 19, 2021."},{"key":"25","unstructured":"25 (2015) Outline of hygiene administration report, the Ministry of Health, Labour and Welfare (at the end of 2015): Number of recipient certificates issued for specific disease treatment (for designated intractable disease) according to age group and disease group. https:\/\/www.nanbyou.or.jp\/wp-content\/uploads\/upload_files\/kouhu20161.pdf accessed on January 19, 2021 (In Japanese)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Sid\u00e9ris L, Dub\u00e9 P, Rinke A (2012) Antitumor effects of somatostatin analogs in neuroendocrine tumors. 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Pituitary 19: 582\u2013589.","DOI":"10.1007\/s11102-016-0749-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Lombardi G, Colao A, Marzullo P, Biondi B, Palmieri E, et al. (2002) Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study. J Endocrinol Invest 25: 971\u2013976.","DOI":"10.1007\/BF03344070"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Burke PG, Li Q, Costin ML, McMullan S, Pilowsky PM, et al. (2008) Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure. Hypertension 52: 1127\u20131133.","DOI":"10.1161\/HYPERTENSIONAHA.108.118224"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Comunello A, Dassie F, Martini C, De Carlo E, Mioni R, et al. (2015) Heart rate variability is reduced in acromegaly patients and improved by treatment with somatostatin analogues. 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Clin Endocrinol (Oxf) 63: 514\u2013519.","DOI":"10.1111\/j.1365-2265.2005.02372.x"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36 Sriphrapradang C, Srichomkwun P, Refetoff S, Mamanasiri S (2016) A novel thyroid hormone receptor beta gene mutation (G251V) in a Thai patient with resistance to thyroid hormone coexisting with pituitary incidentaloma. Thyroid 26: 1804\u20131806.","DOI":"10.1089\/thy.2016.0450"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Teng X, Jin T, Brent GA, Wu A, Teng W, et al. (2015) A patient with a thyrotropin-secreting microadenoma and resistance to thyroid hormone (P453T). J Clin Endocrinol Metab 100: 2511\u20132514.","DOI":"10.1210\/jc.2014-3994"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Mannavola D, Persani L, Vannucchi G, Zanardelli M, Fugazzola L, et al. (2005) Different responses to chronic somatostatin analogues in patients with central hyperthyroidism. 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