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(2017) Practical performance of the 2015 American Thyroid Association Guidelines for predicting tumor recurrence in patients with papillary thyroid cancer in South Korea. Thyroid 27: 174\u2013181.","DOI":"10.1089\/thy.2016.0252"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Grani G, Zatelli MC Alfo M, Montesano T, Torlontano M, et al. (2021) Real-world performance of the American Thyroid Association risk estimates in predicting 1-year differentiated thyroid cancer outcomes: a prospective multicenter study of 2000 patients. Thyroid 31: 264\u2013271.","DOI":"10.1089\/thy.2020.0272"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Pitoia F, Jerkovich F (2019) Dynamic risk assessment in patients with differentiated thyroid cancer. Endocr Relat Cancer 26: R553\u2013R566.","DOI":"10.1530\/ERC-19-0213"},{"key":"42","doi-asserted-by":"publisher","unstructured":"42 Randolph GW, Duh QY, Heller KS, LiVolsi VA, Mandel SJ, et al. 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(2017) American Thyroid Association guidelines on the management of thyroid nodules and differentiated thyroid cancer task force review and recommendation on the proposed renaming of encapsulated follicular variant papillary thyroid carcinoma without invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Thyroid 27: 481\u2013483.","DOI":"10.1089\/thy.2016.0628"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51 Ferris RL, Nikiforov Y, Terris D, Seethala RR, Ridge JA, et al. (2018) AHNS series: do you know your guidelines? AHNS endocrine section consensus statement: state-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Head Neck 40: 1881\u20131888.","DOI":"10.1002\/hed.25141"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52 Saad AG, Kumar S, Ron E, Lubin JH, Stanek J, et al. 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