{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:55:28Z","timestamp":1792029328060,"version":"4.4.0"},"reference-count":26,"publisher":"Japan Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1507\/endocrj.ej21-0390","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T18:07:52Z","timestamp":1632247672000},"page":"179-188","source":"Crossref","is-referenced-by-count":9,"title":["Clinical outcomes of 34 patients with resistance to thyroid hormone beta: a twenty-year experience in Japan"],"prefix":"10.1507","volume":"69","author":[{"given":"Kenji","family":"Ohba","sequence":"first","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"},{"name":"Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekazu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Misawa Nakamura","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan"},{"name":"Okamoto Thyroid Clinic, Osaka, Osaka 535-0031, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","unstructured":"1 Dumitrescu AM, Korwutthikulrangsri M, Refetoff S (2021) Impaired sensitivity to thyroid hormone: defects of transport, metabolism and action. In: Braverman LE, Cooper DS, Kopp PA (eds) Werner &amp; Ingbar\u2019s The Thyroid: A Fundamental and Clinical Text (11th). Lippincott Williams &amp; Wilkins, Philadelphia, USA: 868\u2013907."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Cheng SY, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31: 139\u2013170.","DOI":"10.1210\/er.2009-0007"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Lafranchi SH, Snyder DB, Sesser DE, Skeels MR, Singh N, et al. (2003) Follow-up of newborns with elevated screening T4 concentrations. J Pediatr 143: 296\u2013301.","DOI":"10.1067\/S0022-3476(03)00184-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Tajima T, Jo W, Fujikura K, Fukushi M, Fujieda K (2009) Elevated free thyroxine levels detected by a neonatal screening system. Pediatr Res 66: 312\u2013316.","DOI":"10.1203\/PDR.0b013e3181b1bcbd"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Tagami T (2021) An overview of thyroid function tests in subjects with resistance to thyroid hormone and related disorders. Endocr J 68: 509\u2013517.","DOI":"10.1507\/endocrj.EJ21-0059"},{"key":"6","unstructured":"6 Japan Thyroid Association (2016) Diagnosis of the resistance to thyroid hormone beta (RTH\u03b2). http:\/\/www.japanthyroid.jp\/doctor\/img\/hormone03.pdf accessed on May 18, 2021."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Ohba K (2021) An update on the pathophysiology and diagnosis of inappropriate secretion of thyroid-stimulating hormone. Int J Mol Sci 22: 6611.","DOI":"10.3390\/ijms22126611"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Tajiri J (2006) Radioactive iodine therapy for goitrous Hashimoto\u2019s thyroiditis. J Clin Endocrinol Metab 91: 4497\u20134500.","DOI":"10.1210\/jc.2006-1163"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Yamada S, Fukuhara N, Horiguchi K, Yamaguchi-Okada M, Nishioka H, et al. (2014) Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases. J Neurosurg 121: 1462\u20131473.","DOI":"10.3171\/2014.7.JNS1471"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Shinkai S, Ohba K, Kakudo K, Iwaki T, Mimura Y, et al. (2021) Hyperfunctioning papillary thyroid carcinoma with a BRAF mutation: the first case report and a literature review. Eur Thyroid J 10: 262\u2013267.","DOI":"10.1159\/000513552"},{"key":"11","unstructured":"11 Polymorphism Phenotyping ver. 2. http:\/\/genetics.bwh.harvard.edu\/pph2 accessed on July 31, 2021."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, et al. (2020) The differential diagnosis of discrepant thyroid function tests: insistent pitfalls and updated flow-chart based on a long-standing experience. Front Endocrinol (Lausanne) 11: 432.","DOI":"10.3389\/fendo.2020.00432"},{"key":"13","unstructured":"13 Dumitrescu AM, Refetoff S (2015) Impaired sensitivity to thyroid hormone: defects of transport, metabolism and action. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, <i>et al.<\/i> (eds) Endotex [Internet]. MDText.com, Inc. South Dartmouth, Massachusetts, USA."},{"key":"14","unstructured":"14 Beck-Peccoz P, Persani L, Lania A (2019) Thyrotropin-secreting pituitary adenomas. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, <i>et al.<\/i> (eds) Endotex [Internet]. MDText.com, Inc. South Dartmouth, Massachusetts, USA."},{"key":"15","unstructured":"15 Burch HB (2021) Overview of the clinical manifestations of thyrotoxicosis. In: Braverman LE, Cooper DS, Kopp PA (eds) Werner &amp; Ingbar\u2019s The Thyroid: A Fundamental and Clinical Text (11th). Lippincott Williams &amp; Wilkins, Philadelphia, USA: 419\u2013426."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Barkoff MS, Kocherginsky M, Anselmo J, Weiss RE, Refetoff S (2010) Autoimmunity in patients with resistance to thyroid hormone. J Clin Endocrinol Metab 95: 3189\u20133193.","DOI":"10.1210\/jc.2009-2179"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Fukata S, Brent GA, Sugawara M (2005) Resistance to thyroid hormone in Hashimoto\u2019s thyroiditis. N Engl J Med 352: 517\u2013518.","DOI":"10.1056\/NEJM200502033520523"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18 Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, et al. (2010) Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid 20: 917\u2013926.","DOI":"10.1089\/thy.2009.0389"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19 Taniyama M, Otsuka F, Tozaki T, Ban Y (2013) Thyroid profiles in a patient with resistance to thyroid hormone and episodes of thyrotoxicosis, including repeated painless thyroiditis. Thyroid 23: 898\u2013901.","DOI":"10.1089\/thy.2012.0004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, et al. (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab 87: 489\u2013499.","DOI":"10.1210\/jcem.87.2.8182"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Sato H (2010) Clinical features of primary hyperthyroidism caused by Graves\u2019 disease admixed with resistance to thyroid hormone (P453T). Endocr J 57: 687\u2013692.","DOI":"10.1507\/endocrj.K10E-066"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Ramos-Lev\u00ed AM, Moreno JC, \u00c1lvarez-Escol\u00e1 C, Lac\u00e1mara N, Monta\u00f1ez MC (2016) Coexistence of thyroid hormone resistance syndrome, pituitary adenoma and Graves\u2019 disease. Endocrinol Nutr 63: 139\u2013141.","DOI":"10.1016\/j.endonu.2015.12.003"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Ogawa K, Yoshida M, Hayashi Y, Murata Y, Miyata M, et al. (2011) A rare case of resistance to thyroid hormone coexisting with Graves\u2019 disease. Endocrine 40: 318\u2013319.","DOI":"10.1007\/s12020-011-9491-0"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Shiwa T, Oki K, Awaya T, Nakanishi S, Yamane K (2011) Resistance to thyroid hormone accompanied by Graves\u2019 disease. Intern Med 50: 1977\u20131980.","DOI":"10.2169\/internalmedicine.50.4904"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Sun H, Xu S, Xie S, Cao W, Chen G, et al. (2017) Graves\u2019 disease coexisting with resistance to thyroid hormone: a rare case. Clin Case Rep 6: 337\u2013341.","DOI":"10.1002\/ccr3.1344"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26 Sivakumar T, Chaidarun S (2010) Resistance to thyroid hormone in a patient with coexisting Graves\u2019 disease. Thyroid 20: 213\u2013216.","DOI":"10.1089\/thy.2009.0175"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/69\/2\/69_EJ21-0390\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T01:21:51Z","timestamp":1715217711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/69\/2\/69_EJ21-0390\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej21-0390","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"EJ21-0390"}}