{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:31:58Z","timestamp":1774477918930,"version":"3.50.1"},"reference-count":39,"publisher":"Japan Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1507\/endocrj.ej22-0075","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T22:10:11Z","timestamp":1658355011000},"page":"1387-1394","source":"Crossref","is-referenced-by-count":3,"title":["Increases in serum carbonylated protein levels of dogs with hypercortisolism"],"prefix":"10.1507","volume":"69","author":[{"given":"HakChung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tamahara","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoaki","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Kemppainen RJ, Peterson EM (1994) Animal models of Cushing\u2019s disease. Trends Endocrinol Metab 5: 21\u201328.","DOI":"10.1016\/1043-2760(94)90117-1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Kooistra HS, Galac S (2012) Recent advances in the diagnosis of Cushing\u2019s syndrome in dogs. Top Companion Anim Med 27: 21\u201324.","DOI":"10.1053\/j.tcam.2012.06.001"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Peterson ME (2007) Diagnosis of hyperadrenocorticism in dogs. Clin Tech Small Anim Pract 22: 2\u201311.","DOI":"10.1053\/j.ctsap.2007.02.007"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Bjelakovi\u0107 G, Beninati S, Pavlovi\u0107 D, Koci\u0107 G, Jevtovi\u0107 T, et al. (2007) Glucocorticoids and oxidative stress. J Basic Clin Physiol Pharmacol 18: 115\u2013127.","DOI":"10.1515\/JBCPP.2007.18.2.115"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Karamouzis I, Berardelli R, D\u2019Angelo V, Fussotto B, Zichi C, et al. (2015) Enhanced oxidative stress and platelet activation in patients with Cushing\u2019s syndrome. Clin Endocrinol (Oxf) 82: 517\u2013524.","DOI":"10.1111\/cen.12524"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Pr\u00e1zn\u00fd M, Je\u017ekov\u00e1 J, Horov\u00e1 E, Laz\u00e1rov\u00e1 V, H\u00e1na V, et al. (2008) Impaired microvascular reactivity and endothelial function in patients with Cushing\u2019s syndrome: influence of arterial hypertension. Physiol Res 57: 13\u201322.","DOI":"10.33549\/physiolres.931126"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7 Zafir A, Banu N (2009) Modulation of <i>in vivo<\/i> oxidative status by exogenous corticosterone and restraint stress in rats. Stress 12: 167\u2013177.","DOI":"10.1080\/10253890802234168"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Curtis JM, Hahn WS, Long EK, Burrill JS, Arriaga EA, et al. (2012) Protein carbonylation and metabolic control systems. Trends Endocrinol Metab 23: 399\u2013406.","DOI":"10.1016\/j.tem.2012.05.008"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Dalle-Donne I, Aldini G, Carini M, Colombo R, Rossi R, et al. (2006) Protein carbonylation, cellular dysfunction, and disease progression. J Cell Mol Med 10: 389\u2013406.","DOI":"10.1111\/j.1582-4934.2006.tb00407.x"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10 Stadtman ER, Levine RL (2003) Free radical-mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acids 25: 207\u2013218.","DOI":"10.1007\/s00726-003-0011-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 de Bruin C, Meij BP, Kooistra HS, Hanson JM, Lamberts SW, et al. (2009) Cushing\u2019s disease in dogs and humans. Horm Res 71: 140\u2013143.","DOI":"10.1159\/000178058"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Soares FAC, Filho NAK, Beretta BFS, Linden TS, P\u00f6ppl AG, et al. (2021) Thiobarbituric acid reactive substances in dogs with spontaneous hypercortisolism. Domest Anim Endocrinol 77: 106634.","DOI":"10.1016\/j.domaniend.2021.106634"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Ferreira CS, Vasconcellos RS, Pedreira RS, Silva FL, S\u00e1 FC, et al. (2014) Alterations to oxidative stress markers in dogs after a short-term stress during transport. J Nutr Sci 3: e27.","DOI":"10.1017\/jns.2014.47"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Pacheco GFE, Bortolin RC, Chaves PR, Moreira JCF, Kessler AM, et al. (2018) Effects of the consumption of polyunsaturated fatty acids on the oxidative status of adult dogs. J Anim Sci 96: 4590\u20134598.","DOI":"10.1093\/jas\/sky313"},{"key":"15","unstructured":"15 Feldman EC, Nelson RW (2003) Canine hyperadrenocorticism (Cushing\u2019s syndrome). In: Canine and Feline Endocrinology and Reproduction (3rd). Saunders, St Louis, USA: 253\u2013357."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Alamdari DH, Kostidou E, Paletas K, Sarigianni M, Konstas AG, et al. (2005) High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein. Free Radic Biol Med 39: 1362\u20131367.","DOI":"10.1016\/j.freeradbiomed.2005.06.023"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Keller RJ, Halmes NC, Hinson JA, Pumford NR (1993) Immunochemical detection of oxidized proteins. Chem Res Toxicol 6: 430\u2013433.","DOI":"10.1021\/tx00034a007"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Robinson CE, Keshavarzian A, Pasco DS, Frommel TO, Winship DH, et al. (1999) Determination of protein carbonyl groups by immunoblotting. Anal Biochem 266: 48\u201357.","DOI":"10.1006\/abio.1998.2932"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Bermejo CA, Alenza DP, San Jos\u00e9 PG, Llauet L, P\u00e9rez-L\u00f3pez L, et al. (2020) Laboratory assessment of trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med 34: 1413\u20131422.","DOI":"10.1111\/jvim.15830"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Boretti F, Musella C, Burkhardt W, Kuemmerle-Fraune C, Riond B, et al. (2018) Comparison of two prepill cortisol concentrations in dogs with hypercortisolism treated with trilostane. BMC Vet Res 14: 417.","DOI":"10.1186\/s12917-018-1750-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Golinelli S, de Marco V, Leal RO, Barbarossa A, Aniballi C, et al. (2021) Comparison of methods to monitor dogs with hypercortisolism treated with trilostane. J Vet Intern Med 35: 2616\u20132627.","DOI":"10.1111\/jvim.16269"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Macfarlane L, Parkin T, Ramsey I (2016) Pre-trilostane and three-hour post-trilostane cortisol to monitor trilostane therapy in dogs. Vet Rec 179: 597.","DOI":"10.1136\/vr.103744"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Schofield I, O\u2019Neill DG, Brodbelt DC, Church DB, Geddes RF, et al. (2019) Development and evaluation of a health-related quality-of-life tool for dogs with Cushing\u2019s syndrome. J Vet Intern Med 33: 2595\u20132604.","DOI":"10.1111\/jvim.15639"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Harvey JW, West CL (1987) Prednisone-induced increases in serum alpha-2-globulin and haptoglobin concentrations in dogs. Vet Pathol 24: 90\u201392.","DOI":"10.1177\/030098588702400115"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Martinez-Subiela S, Ginel PJ, Ceron JJ (2004) Effects of different glucocorticoid treatments on serum acute phase proteins in dogs. Vet Rec 154: 814\u2013817.","DOI":"10.1136\/vr.154.26.814"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 McGrotty YL, Knottenbelt CM, Ramsey IK, Reid SWJ, Eckersall PD (2003) Haptoglobin concentrations in a canine hospital population. Vet Rec 152: 562\u2013564.","DOI":"10.1136\/vr.152.18.562"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Arteaga A, Dhand NK, McCann T, Knottenbelt CM, Tebb AJ, et al. (2010) Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. J Small Anim Pract 51: 204\u2013209.","DOI":"10.1111\/j.1748-5827.2009.00863.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 McGrotty YL, Arteaga A, Knottenbelt CM, Ramsey IK, Eckersall PD (2005) Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Vet Clin Pathol 34: 255\u2013258.","DOI":"10.1111\/j.1939-165X.2005.tb00050.x"},{"key":"29","unstructured":"29 Ramsey IK, Sieber-Ruckstuhl N, Woods G, McComb C, Eckersall PD (2018) Haptoglobin and pre-trilostane cortisol as monitoring tools for the treatment of canine hyperadrenocorticism. Program of 28th European College of Veterinary Internal Medicine - Companion Animals (ECVIM-CA) Congress, ESVE-O-5 (Abstract)."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Boretti FS, Baek JH, Palmer AF, Schaer DJ, Buehler PW (2014) Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Front Physiol 5: 385.","DOI":"10.3389\/fphys.2014.00385"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Boretti FS, Buehler PW, D\u2019Agnillo F, Kluge K, Glaus T, et al. (2009) Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest 119: 2271\u20132280.","DOI":"10.1172\/JCI39115"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW (2014) Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol 5: 415.","DOI":"10.3389\/fphys.2014.00415"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Ceron JJ, Eckersall PD, Mart\u00fdnez-Subiela S (2005) Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol 34: 85\u201399.","DOI":"10.1111\/j.1939-165X.2005.tb00019.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Au AY, Hasenwinkel JM, Frondoza CG (2013) Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes <i>in vitro<\/i>. J Anim Physiol Anim Nutr (Berl) 97: 331\u2013341.","DOI":"10.1111\/j.1439-0396.2012.01275.x"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Barrouin-Melo SM, Anturaniemi J, Sankari S, Griinari M, Atroshi F, et al. (2016) Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil. Lipids Health Dis 15: 139.","DOI":"10.1186\/s12944-016-0304-6"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Tang VM, Young AH, Tan H, Beasley C, Wang JF (2013) Glucocorticoids increase protein carbonylation and mitochondrial dysfunction. Horm Metab Res 45: 709\u2013715.","DOI":"10.1055\/s-0033-1345119"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Abidin I, Yargi\u00e7oglu P, Agar A, G\u00fcm\u00fcsl\u00fc S, Aydin S, et al. (2004) The effect of chronic restraint stress on spatial learning and memory: relation to oxidant stress. Int J Neurosci 114: 683\u2013699.","DOI":"10.1080\/00207450490430543"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, et al. (2009) Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood 113: 2578\u20132586.","DOI":"10.1182\/blood-2008-08-174466"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Kato GJ (2009) Haptoglobin halts hemoglobin\u2019s havoc. J Clin Invest 119: 2140\u20132142.","DOI":"10.1172\/JCI40258"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/69\/12\/69_EJ22-0075\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T03:12:35Z","timestamp":1672456355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/69\/12\/69_EJ22-0075\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej22-0075","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"EJ22-0075"}}