{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T15:20:28Z","timestamp":1748791228556,"version":"3.37.3"},"reference-count":33,"publisher":"Japan Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1507\/endocrj.ej23-0550","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T22:11:30Z","timestamp":1705702290000},"page":"305-312","source":"Crossref","is-referenced-by-count":1,"title":["New onset of isolated adrenocorticotropin deficiency associated with encephalopathy following coronavirus disease 2019 in a healthy elderly man"],"prefix":"10.1507","volume":"71","author":[{"given":"Yusuke","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-5796","authenticated-orcid":false,"given":"Ichiro","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyoko","family":"Shigeno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Nishikido","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Ikeoka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Strokology, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1 Bellastella G, Cirillo P, Carbone C, Scappaticcio L, Maio A, et al. (2022) Neuroimmunoendocrinology of SARS-CoV 2 Infection. Biomedicines 10: 2855.","DOI":"10.3390\/biomedicines10112855"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Pal R (2020) COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications. Endocrine 68: 251\u2013252.","DOI":"10.1007\/s12020-020-02325-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Cho SM, White N, Premraj L, Battaglini D, Fanning J, et al. (2023) Neurological manifestations of COVID-19 in adults and children. Brain 146: 1648\u20131661.","DOI":"10.1093\/brain\/awac332"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Chang S, Schecht M, Jain R, Belani P (2023) Acute neurological complications of coronavirus disease. Neuroimaging Clin N Am 33: 57\u201368.","DOI":"10.1016\/j.nic.2022.07.003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Pal R, Banerjee M (2020) COVID-19 and the endocrine system: exploring the unexplored. J Endocrinol Invest 43: 1027\u20131031.","DOI":"10.1007\/s40618-020-01276-8"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Medina-Enriquez MM, Lopez-Leon S, Carlos-Escalante JA, Aponte-Torres Z, Cuapio A, et al. (2020) ACE2: the molecular doorway to SARS-CoV-2. Cell Biosci 10: 148.","DOI":"10.1186\/s13578-020-00519-8"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Puig-Domingo M, Marazuela M, Yildiz BO, Giustina A (2021) COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology. Endocrine 72: 301\u2013316.","DOI":"10.1007\/s12020-021-02734-w"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Valencia Sanchez C, Theel E, Binnicker M, Toledano M, McKeon A (2021) Autoimmune encephalitis after SARS-CoV-2 infection: case frequency, findings, and outcomes. Neurology 97: e2262\u2013e2268.","DOI":"10.1212\/WNL.0000000000012931"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Murakami M, Matsushita N, Arai R, Takahashi N, Kawamura R, et al. (2012) Isolated adrenocorticotropin deficiency associated with delirium and takotsubo cardiomyopathy. Case Rep Endocrinol 2012: 580481.","DOI":"10.1155\/2012\/580481"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Nwokolo M, Fletcher J (2013) A rare case of hypopituitarism with psychosis. Endocrinol Diabetes Metab Case Rep 2013: 130007.","DOI":"10.1530\/EDM-13-0007"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Imai H, Matsuishi K, Kitamura N, Matsui Y, Tamiya S, et al. (2009) Isolated adrenocorticotropic hormone deficiency accompanied with delirium. Psychiatry Clin Neurosci 63: 426\u2013427.","DOI":"10.1111\/j.1440-1819.2009.01949.x"},{"key":"12","unstructured":"12 Nieman LK (2022) Clinical manifestations of adrenal insufficiency in adults. <i>UpToDate<\/i> https:\/\/www.uptodate.com\/contents\/clinical-manifestations-of-adrenal-insufficiency-in-adults accessed on Nov 10, 2023."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Abenza Abildua MJ, Atienza S, Carvalho Monteiro G, Erro Aguirre ME, Imaz Aguayo L, et al. (2021) Encephalopathy and encephalitis during acute SARS-CoV-2 infection. Spanish society of neurology COVID-19 registry. Neurologia (Engl Ed) 36: 127\u2013134.","DOI":"10.1016\/j.nrleng.2020.11.003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Jarius S, Pache F, Kortvelyessy P, Jelcic I, Stettner M, et al. (2022) Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients. J Neuroinflammation 19: 19.","DOI":"10.1186\/s12974-021-02339-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Tibbling G, Link H, Ohman S (1977) Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand J Clin Lab Invest 37: 385\u2013390.","DOI":"10.1080\/00365517709091496"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Reiber H, Peter JB (2001) Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 184: 101\u2013122.","DOI":"10.1016\/S0022-510X(00)00501-3"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Kato S, Yoshikura N, Kimura A, Shimohata T (2022) Possible autoimmune encephalitis associated with the severe acute respiratory syndrome coronavirus 2 omicron variant successfully treated with steroids: a case report. Intern Med 61: 3739\u20133741.","DOI":"10.2169\/internalmedicine.0371-22"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Chakraborty AP, Pandit A, Dutta A, Das S, Ganguly G, et al. (2022) Transcortical sensory aphasia heralding SARS-Cov-2-induced autoimmune encephalitis with gyral restricted diffusion hyperintensities: a novel case report. Egypt J Neurol Psychiatr Neurosurg 58: 167.","DOI":"10.1186\/s41983-022-00593-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Hilado M, Banh M, Homans J, Partikian A (2022) Pediatric autoimmune encephalitis following COVID-19 infection. J Child Neurol 37: 268\u2013272.","DOI":"10.1177\/08830738211069814"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Dono F, Carrarini C, Russo M, De Angelis MV, Anzellotti F, et al. (2021) New-onset refractory status epilepticus (NORSE) in post SARS-CoV-2 autoimmune encephalitis: a case report. Neurol Sci 42: 35\u201338.","DOI":"10.1007\/s10072-020-04846-z"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Dahshan A, Abdellatef AA (2022) Autoimmune encephalitis as a complication of COVID-19 infection: a case report. Egypt J Intern Med 34: 32.","DOI":"10.1186\/s43162-022-00119-7"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Grimaldi S, Lagarde S, Harle JR, Boucraut J, Guedj E (2020) Autoimmune encephalitis concomitant with SARS-CoV-2 infection: insight from (18)F-FDG PET imaging and neuronal autoantibodies. J Nucl Med 61: 1726\u20131729.","DOI":"10.2967\/jnumed.120.249292"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Yoshimura K, Yamamoto M, Inoue T, Fukuoka H, Iida K, et al. (2022) Coexistence of growth hormone, adrenocorticotropic hormone, and testosterone deficiency associated with coronavirus disease 2019: a case followed up for 15 months. Endocr J 69: 1335\u20131342.","DOI":"10.1507\/endocrj.EJ22-0108"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Hamazaki K, Nishigaki T, Kuramoto N, Oh K, Konishi H (2022) Secondary adrenal insufficiency after COVID-19 diagnosed by insulin tolerance test and corticotropin-releasing hormone test. Cureus 14: e23021.","DOI":"10.7759\/cureus.23021"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Gorbova NY, Vladimirova VP, Rozhinskaya LY, Belaya ZY (2022) [Hypophysitis and reversible hypopituitarism developed after COVID-19 infection\u2014a clinical case report]. Probl Endokrinol (Mosk) 68: 50\u201356.","DOI":"10.14341\/probl12896"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Chua MWJ, Chua MPW (2021) Delayed onset of central hypocortisolism in a patient recovering from COVID-19. AACE Clin Case Rep 7: 2\u20135.","DOI":"10.1016\/j.aace.2020.11.001"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Muller JA, Gross R, Conzelmann C, Kruger J, Merle U, et al. (2021) SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab 3: 149\u2013165.","DOI":"10.1038\/s42255-021-00347-1"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Frara S, Loli P, Allora A, Santini C, di Filippo L, et al. (2022) COVID-19 and hypopituitarism. Rev Endocr Metab Disord 23: 215\u2013231.","DOI":"10.1007\/s11154-021-09672-y"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Poma AM, Proietti A, Macerola E, Bonuccelli D, Conti M, et al. (2022) Suppression of pituitary hormone genes in subjects who died from COVID-19 independently of virus detection in the gland. J Clin Endocrinol Metab 107: 2243\u20132253.","DOI":"10.1210\/clinem\/dgac312"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Leow MK, Kwek DS, Ng AW, Ong KC, Kaw GJ, et al. (2005) Hypocortisolism in survivors of severe acute respiratory syndrome (SARS). Clin Endocrinol (Oxf) 63: 197\u2013202.","DOI":"10.1111\/j.1365-2265.2005.02325.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Gonen MS, De Bellis A, Durcan E, Bellastella G, Cirillo P, et al. (2022) Assessment of neuroendocrine changes and hypothalamo-pituitary autoimmunity in patients with COVID-19. Horm Metab Res 54: 153\u2013161.","DOI":"10.1055\/a-1764-1260"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Das L, Dutta P, Walia R, Mukherjee S, Suri V, et al. (2021) Spectrum of endocrine dysfunction and association with disease severity in patients with COVID-19: insights from a cross-sectional, observational study. Front Endocrinol (Lausanne) 12: 645787.","DOI":"10.3389\/fendo.2021.645787"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Morita S, Tsuji T, Kishimoto S, Uraki S, Takeshima K, et al. (2022) Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report. BMC Endocr Disord 22: 185.","DOI":"10.1186\/s12902-022-01095-3"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/71\/3\/71_EJ23-0550\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T04:17:48Z","timestamp":1711772268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/71\/3\/71_EJ23-0550\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej23-0550","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"type":"print","value":"0918-8959"},{"type":"electronic","value":"1348-4540"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"EJ23-0550"}}