{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:22:32Z","timestamp":1768519352462,"version":"3.49.0"},"reference-count":24,"publisher":"Japan Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1507\/endocrj.ej24-0061","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T22:11:42Z","timestamp":1714687902000},"page":"799-807","source":"Crossref","is-referenced-by-count":4,"title":["A case of hypophysitis after COVID-19 vaccination with a detection of anti-pituitary antibody, with review of literature"],"prefix":"10.1507","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9275-3387","authenticated-orcid":false,"given":"Chika","family":"Kyo","sequence":"first","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumikazu","family":"Sawabe","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Hayafusa","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kotani","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhide","family":"Inoue","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ariyasu","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka 420-8527, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Menni C, Klaser K, May A, Polidori L, Capdevila J, et al. (2021) Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis 21: 939\u2013949.","DOI":"10.1016\/S1473-3099(21)00224-3"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Knudsen B, Prasad V (2023) COVID-19 vaccine induced myocarditis in young males: a systematic review. Eur J Clin Invest 53: e13947.","DOI":"10.1111\/eci.13947"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Cancarevic I, Nassar M, Medina L, Sanchez A, Parikh A, et al. (2022) Nephrotic syndrome in adult patients with COVID-19 infection or post COVID-19 vaccine: a systematic review. Cureus 14: e29613.","DOI":"10.7759\/cureus.29613"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Morita S, Tsuji T, Kishimoto S, Uraki S, Takeshima K, et al. (2022) Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report. BMC Endocr Disord 22: 185.","DOI":"10.1186\/s12902-022-01095-3"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Taieb A, Mounira EE (2022) Pilot findings on SARS-CoV-2 vaccine-induced pituitary diseases: a mini review from diagnosis to pathophysiology. Vaccines (Basel) 10: 2004.","DOI":"10.3390\/vaccines10122004"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Murvelashvili N, Tessnow A (2021) A case of hypophysitis following immunization with the mRNA-1273 SARS-CoV-2 vaccine. J Investig Med High Impact Case Rep 9: 23247096211043386.","DOI":"10.1177\/23247096211043386"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7 Roncati L, Manenti A (2023) Pituitary apoplexy following adenoviral vector-based COVID-19 vaccination. Brain Hemorrhages 4: 27\u201329.","DOI":"10.1016\/j.hest.2022.04.002"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Bou\u00e7a B, Rold\u00e3o M, Bogalho P, Cerqueira L, Silva-Nunes J (2022) Central diabetes insipidus following immunization with BNT162b2 mRNA COVID-19 vaccine: a case report. Front Endocrinol (Lausanne) 13: 889074.","DOI":"10.3389\/fendo.2022.889074"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Ankireddypalli AR, Chow LS, Radulescu A, Kawakami Y, Araki T (2022) A case of hypophysitis associated with SARS-CoV-2 vaccination. AACE Clin Case Rep 8: 204\u2013209.","DOI":"10.1016\/j.aace.2022.06.001"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10 Ach T, Kammoun F, Fekih HE, Slama NBH, Kahloun S, et al. (2023) Central diabetes insipidus revealing a hypophysitis induced by SARS-CoV-2 vaccine. Therapie 78: 453\u2013455.","DOI":"10.1016\/j.therap.2022.09.007"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Ishay A, Shacham EC (2023) Central diabetes insipidus: a late sequela of BNT162b2 SARS-CoV-2 mRNA vaccine? BMC Endocr Disord 23: 47.","DOI":"10.1186\/s12902-023-01296-4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Matsuo T, Okubo K, Mifune H, Imao T (2023) Bilateral optic neuritis and hypophysitis with diabetes insipidus 1 month after COVID-19 mRNA vaccine: case report and literature review. J Investig Med High Impact Case Rep 11: 23247096231186046.","DOI":"10.1177\/23247096231186046"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, et al. (2021) Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. J Immunother Cancer 9: 002493.","DOI":"10.1136\/jitc-2021-002493"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Iwama S, Arima H (2020) Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands. Endocr J 67: 1077\u20131083.","DOI":"10.1507\/endocrj.EJ20-0436"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Ricciuti A, De Remigis A, Landek-Salgado MA, De Vincentiis L, Guaraldi F, et al. (2014) Detection of pituitary antibodies by immunofluorescence: approach and results in patients with pituitary diseases. J Clin Endocrinol Metab 99: 1758\u20131766.","DOI":"10.1210\/jc.2014-1049"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P, et al. (2013) Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells. J Clin Endocrinol Metab 98: 3920\u20133925.","DOI":"10.1210\/jc.2013-2411"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Bragazzi NL, Hejly A, Watad A, Adawi M, Amital H, et al. (2020) ASIA syndrome and endocrine autoimmune disorders. Best Pract Res Clin Endocrinol Metab 34: 101412.","DOI":"10.1016\/j.beem.2020.101412"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Devnath S, Inoue K (2008) An insight to pituitary folliculo-stellate cells. J Neuroendocrinol 20: 687\u2013691.","DOI":"10.1111\/j.1365-2826.2008.01716.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Horiguchi K, Higuchi M, Yoshida S, Nakakura T, Tateno K, et al. (2014) Proton receptor GPR68 expression in dendritic-cell-like S100\u03b2-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification. Cell Tissue Res 358: 515\u2013525.","DOI":"10.1007\/s00441-014-1958-x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Horiguchi K, Fujiwara K, Higuchi M, Yoshida S, Tsukada T, et al. (2014) Expression of chemokine CXCL10 in dendritic-cell-like S100\u03b2-positive cells in rat anterior pituitary gland. Cell Tissue Res 357: 757\u2013765.","DOI":"10.1007\/s00441-014-1864-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Fujita Y, Bando H, Iguchi G, Iida K, Nishizawa H, et al. (2021) Clinical heterogeneity of acquired idiopathic isolated adrenocorticotropic hormone deficiency. Front Endocrinol (Lausanne) 12: 578802.","DOI":"10.3389\/fendo.2021.578802"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Kurteva E, Vasilev G, Tumangelova-Yuzeir K, Ivanova I, Ivanova-Todorova E, et al. (2022) Interferon-gamma release assays outcomes in healthy subjects following BNT162b2 mRNA COVID-19 vaccination. Rheumatol Int 42: 449\u2013456.","DOI":"10.1007\/s00296-022-05091-7"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Wang X, Yuen TT, Dou Y, Hu J, Li R, et al. (2023) Vaccine-induced protection against SARS-CoV-2 requires IFN-\u03b3-driven cellular immune response. Nat Commun 14: 3440.","DOI":"10.1038\/s41467-023-39096-y"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, et al. (2018) Patients with antithyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study. J Endocr Soc 2: 241\u2013251.","DOI":"10.1210\/js.2017-00432"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/71\/8\/71_EJ24-0061\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T04:08:24Z","timestamp":1723262904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/71\/8\/71_EJ24-0061\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej24-0061","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"EJ24-0061"}}