{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:58:10Z","timestamp":1784890690439,"version":"3.55.0"},"reference-count":19,"publisher":"Japan Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1507\/endocrj.ej24-0259","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T22:11:19Z","timestamp":1729635079000},"page":"69-77","source":"Crossref","is-referenced-by-count":2,"title":["Current status of the thyroid hormone measurement items in patients receiving levothyroxine monotherapy by the management based on the thyroid tissue volume"],"prefix":"10.1507","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-5786","authenticated-orcid":false,"given":"Mitsuru","family":"Ito","sequence":"first","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Deguchi-Horiuchi","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Hisakado","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kohsaka","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijun","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Fukata","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsushige","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akamizu","sequence":"additional","affiliation":[{"name":"Center for Excellence in Thyroid Care, Kuma Hospital, Hyogo 650-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Pilo A, Iervasi G, Vitek F, Ferdeghini M, Cazzuola F, et al. (1990) Thyroidal and peripheral production of 3,5,3&apos;-triiodothyronine in humans by multicompartmental analysis. Am J Physiol 258: E715\u2013E726.","DOI":"10.1152\/ajpendo.1990.258.4.E715"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Ito M, Miyauchi A, Morita S, Kudo T, Nishihara E, et al. (2012) TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. Eur J Endocrinol 167: 373\u2013378.","DOI":"10.1530\/EJE-11-1029"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Jonklaas J, Davidson B, Bhagat S, Soldin SJ (2008) Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA 299: 769\u2013777.","DOI":"10.1001\/jama.299.7.769"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, et al. (2011) Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. PLoS One 6: e22552.","DOI":"10.1371\/journal.pone.0022552"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, et al. (2014) Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment. Clin Endocrinol (Oxf) 81: 907\u2013915.","DOI":"10.1111\/cen.12527"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Ito M, Kawasaki M, Danno H, Kohsaka K, Nakamura T, et al. (2019) Serum thyroid hormone balance in levothyroxine monotherapy-treated patients with atrophic thyroid after radioiodine treatment for Graves\u2019 disease. Thyroid 29: 1364\u20131370.","DOI":"10.1089\/thy.2019.0135"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, et al. (2015) Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest 125: 769\u2013781.","DOI":"10.1172\/JCI77588"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Ito M, Miyauchi A, Hisakado M, Yoshioka W, Ide A, et al. (2017) Biochemical markers reflecting thyroid function in athyreotic patients on levothyroxine monotherapy. Thyroid 27: 484\u2013490.","DOI":"10.1089\/thy.2016.0426"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Ito M, Miyauchi A, Hisakado M, Yoshioka W, Kudo T, et al. (2019) Thyroid function related symptoms during levothyroxine monotherapy in athyreotic patients. Endocr J 66: 953\u2013960.","DOI":"10.1507\/endocrj.EJ19-0094"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Peterson SJ, McAninch EA, Bianco AC (2016) Is a normal TSH synonymous with \u201ceuthyroidism\u201d in levothyroxine monotherapy? J Clin Endocrinol Metab 101: 4964\u20134973.","DOI":"10.1210\/jc.2016-2660"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Ito M, Miyauchi A, Kang S, Hisakado M, Yoshioka W, et al. (2015) Effect of the presence of remnant thyroid tissue on the serum thyroid hormone balance in thyroidectomized patients. Eur J Endocrinol 173: 333\u2013340.","DOI":"10.1530\/EJE-15-0138"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Takahashi S, Ito M, Masaki Y, Hada M, Minakata M, et al. (2021) Association between serum thyroid hormone balance and thyroid volume in patients treated with levothyroxine monotherapy for hypothyroidism. Endocr J 68: 353\u2013360.","DOI":"10.1507\/endocrj.EJ20-0542"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13 Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, et al. (2014) Guidelines for the treatment of hypothyroidism: American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid 24: 1670\u20131751.","DOI":"10.1089\/thy.2014.0028"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Murakami Y, Takamatsu J, Sakane S, Kuma K, Ohsawa N (1996) Changes in thyroid volume in response to radioactive iodine for Graves\u2019 hyperthyroidism correlated with activity of thyroid-stimulating antibody and treatment outcome. J Clin Endocrinol Metab 81: 3257\u20133260.","DOI":"10.1210\/jcem.81.9.8784079"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, et al. (2018) Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 14: 301\u2013316.","DOI":"10.1038\/nrendo.2018.18"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Wennlund A (1986) Variation in serum levels of T<sub>3<\/sub>, T<sub>4<\/sub>, FT<sub>4<\/sub> and TSH during thyroxine replacement therapy. Acta Endocrinol (Copenh) 113: 47\u201349.","DOI":"10.1530\/acta.0.1130047"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17 Ain KB, Pucino F, Shiver TM, Banks SM (1993) Thyroid hormone levels affected by time of blood sampling in thyroxine-treated patients. Thyroid 3: 81\u201385.","DOI":"10.1089\/thy.1993.3.81"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Jansen HI, Bult MM, Bisschop PH, Boelen A, Heijboer AC, et al. (2023) Increased fT4 concentrations in patients using levothyroxine without complete suppression of TSH. Endocr Connect 12: e220538.","DOI":"10.1530\/EC-22-0538"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Ito M, Takahashi S, Okazaki-Hada M, Minakata M, Kohsaka K, et al. (2022) Proportion of serum thyroid hormone concentrations within the reference ranges in athyreotic patients on levothyroxine monotherapy: a retrospective study. Thyroid Res 15: 9.","DOI":"10.1186\/s13044-022-00127-3"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/1\/72_EJ24-0259\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T03:34:42Z","timestamp":1736566482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/1\/72_EJ24-0259\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej24-0259","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"EJ24-0259"}}