{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:20Z","timestamp":1792035980741,"version":"4.4.0"},"reference-count":41,"publisher":"Japan Endocrine Society","issue":"2","funder":[{"name":"Atomic Bomb Disease Institute, Nagasaki University"},{"name":"Program of the Network-Type Joint Usage\/Research Center for Radiation Disaster Medical Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1507\/endocrj.ej24-0504","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T22:12:58Z","timestamp":1733177578000},"page":"221-227","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients"],"prefix":"10.1507","volume":"72","author":[{"given":"Van Phu Thang","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kurohama","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Ngoc Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Mussazhanova","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yokota","sequence":"additional","affiliation":[{"name":"Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Satoh","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Nhung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerkerzhan","family":"Sailaubekova","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-8735","authenticated-orcid":false,"given":"Masahiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Massimino M, Evans DB, Podda M, Spinelli C, Collini P, et al. (2018) Thyroid cancer in adolescents and young adults. Pediatr Blood Cancer 65: e27025.","DOI":"10.1002\/pbc.27025"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Asakage T (2022) Epidemiology and treatment of head and neck malignancies in the AYA generation. Int J Clin Oncol 27: 465\u2013472.","DOI":"10.1007\/s10147-021-02093-6"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Gupta S, Harper A, Ruan Y, Barr R, Frazier AL, et al. (2020) International trends in the incidence of cancer among adolescents and young adults. J Natl Cancer Inst 112: 1105\u20131117.","DOI":"10.1093\/jnci\/djaa007"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Mols F, Schoormans D, Smit JWA, Netea-Maier RT, Links TP, et al. (2018) Age-related differences in health-related quality of life among thyroid cancer survivors compared with a normative sample: results from the PROFILES Registry. Head Neck 40: 2235\u20132245.","DOI":"10.1002\/hed.25325"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Okamura M, Fujimori M, Goto S, Obama K, Kadowaki M, et al. (2023) Prevalence and associated factors of psychological distress among young adult cancer patients in Japan. Palliat Support Care 21: 93\u201399.","DOI":"10.1017\/S1478951521002054"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Akechi T, Mishiro I, Fujimoto S (2022) Risk of major depressive disorder in adolescent and young adult cancer patients in Japan. Psychooncology 31: 929\u2013937.","DOI":"10.1002\/pon.5881"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Goldfarb M, Casillas J (2016) Thyroid cancer-specific quality of life and health-related quality of life in young adult thyroid cancer survivors. Thyroid 26: 923\u2013932.","DOI":"10.1089\/thy.2015.0589"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Husson O, Poort H, Sansom-Daly UM, Netea-Maier R, Links T, et al. (2020) Psychological distress and illness perceptions in thyroid cancer survivors: does age matter? J Adolesc Young Adult Oncol 9: 375\u2013383.","DOI":"10.1089\/jayao.2019.0153"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Goldfarb M, Casillas J (2014) Unmet information and support needs in newly diagnosed thyroid cancer: comparison of adolescents\/young adults (AYA) and older patients. J Cancer Surviv 8: 394\u2013401.","DOI":"10.1007\/s11764-014-0345-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Bhatia S, Pappo AS, Acquazzino M, Allen-Rhoades WA, Barnett M, et al. (2023) Adolescent and young adult (AYA) oncology, version 2.2024, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 21: 851\u2013880.","DOI":"10.6004\/jnccn.2023.0040"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Vriens MR, Moses W, Weng J, Peng M, Griffin A, et al. (2011) Clinical and molecular features of papillary thyroid cancer in adolescents and young adults. Cancer 117: 259\u2013267.","DOI":"10.1002\/cncr.25369"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Wang L, Zheng Y, Ye Y, Jiang Z, Lu J, et al. (2024) Association between different regional lymph node metastases of papillary thyroid carcinoma in adolescents and young adults. Oncol Lett 27: 204.","DOI":"10.3892\/ol.2024.14337"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Sun Y, Liu X, Ouyang W, Feng H, Wu J, et al. (2017) Lymph node characteristics for predicting locoregional recurrence of papillary thyroid cancer in adolescents and young adults. Oral Oncol 66: 22\u201327.","DOI":"10.1016\/j.oraloncology.2016.12.028"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Takami H, Ito Y, Okamoto T, Yoshida A (2011) Therapeutic strategy for differentiated thyroid carcinoma in Japan based on a newly established guideline managed by Japanese Society of Thyroid Surgeons and Japanese Association of Endocrine Surgeons. World J Surg 35: 2014.","DOI":"10.1007\/s00268-010-0832-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Ito Y, Onoda N, Okamoto T (2020) The revised clinical practice guidelines on the management of thyroid tumors by the Japan Associations of Endocrine Surgeons: core questions and recommendations for treatments of thyroid cancer. Endocr J 67: 669\u2013717.","DOI":"10.1507\/endocrj.EJ20-0025"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Ito Y, Kudo T, Kihara M, Takamura Y, Kobayashi K, et al. (2012) Prognosis of low-risk papillary thyroid carcinoma patients: Its relationship with the size of primary tumors. Endocr J 59: 119\u2013125.","DOI":"10.1507\/endocrj.EJ11-0288"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17 Tran B, Roshan D, Abraham E, Wang L, Garibotto N, et al. (2018) The prognostic impact of tumor size in papillary thyroid carcinoma is modified by age. Thyroid 28: 991\u2013996.","DOI":"10.1089\/thy.2017.0607"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Ito Y, Miyauchi A, Kobayashi K, Miya A (2014) Prognosis and growth activity depend on patient age in clinical and subclinical papillary thyroid carcinoma. Endocr J 61: 205\u2013213.","DOI":"10.1507\/endocrj.EJ13-0403"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Moritani S (2020) Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition. Endocr J 67: 941\u2013948.","DOI":"10.1507\/endocrj.EJ19-0523"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Cheng SP, Lee JJ, Chien MN, Kuo CY, Jhuang JY, et al. (2020) Lymphovascular invasion of papillary thyroid carcinoma revisited in the era of active surveillance. Eur J Surg Oncol 46: 1814\u20131819.","DOI":"10.1016\/j.ejso.2020.06.044"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Ywata de Carvalho A, Kohler HF, Gomes CC, Vartanian JG, Kowalski LP (2021) Predictive factors for recurrence of papillary thyroid carcinoma: analysis of 4,085 patients. Acta Otorhinolaryngol Ital 41: 236\u2013242.","DOI":"10.14639\/0392-100X-N1412"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Tanaka A, Matsuse M, Saenko V, Nakao T, Yamanouchi K, et al. (2019) TERT mRNA expression as a novel prognostic marker in papillary thyroid carcinomas. Thyroid 29: 1105\u20131114.","DOI":"10.1089\/thy.2018.0695"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Ueda M, Matsuda K, Kurohama H, Mussazhanova Z, Sailaubekova Y, et al. (2022) Molecular pathological characteristics of thyroid follicular-patterned tumors showing nodule-in-nodule appearance with poorly differentiated component. Cancers (Basel) 14: 3577.","DOI":"10.3390\/cancers14153577"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Otsubo C, Mussazhanova Z, Kurohama H, Shalgimbayeva G, Ueki N, et al. (2022) A new indicator to differentiate thyroid follicular inclusions in cervical lymph nodes from patients with thyroid cancer. Int J Mol Sci 24: 490.","DOI":"10.3390\/ijms24010490"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25 Warner EL, Kent EE, Trevino KM, Parsons HM, Zebrack BJ, et al. (2016) Social well-being among adolescents and young adults with cancer: a systematic review. Cancer 122: 1029\u20131037.","DOI":"10.1002\/cncr.29866"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Andersen NH, Christiansen JA, la Cour K, Aagesen M, Tang LH, et al. (2022) Differences in functioning between young adults with cancer and older age groups: a cross-sectional study. <i>Eur J Cancer Care (Engl)<\/i> 31: e13660.","DOI":"10.1111\/ecc.13660"},{"key":"27","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1186\/s12885-019-5835-6","volume":"19","author":"C Liu","year":"2019","unstructured":"27 Liu C, Xiao C, Chen J, Li X, Feng Z, et al. (2019) Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients. BMC Cancer 19: 622.","journal-title":"BMC Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2407","issn-type":"print"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Zhang Q, Wang Z, Meng X, Duh QY, Chen G (2019) Predictors for central lymph node metastases in CN0 papillary thyroid microcarcinoma (mPTC): a retrospective analysis of 1,304 cases. Asian J Surg 42: 571\u2013576.","DOI":"10.1016\/j.asjsur.2018.08.013"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Wu X, Li BL, Zheng CJ, He XD (2020) Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma. World J Clin Cases 8: 1350\u20131360.","DOI":"10.12998\/wjcc.v8.i8.1350"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Ito Y, Miyauchi A, Kihara M, Takamura Y, Kobayashi K, et al. (2012) Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study. Endocr J 59: 399\u2013405.","DOI":"10.1507\/endocrj.EJ12-0044"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Ito Y, Miyauchi A, Kihara M, Higashiyama T, Kobayashi K, et al. (2014) Prognostic significance of young age in papillary thyroid carcinoma: analysis of 5,733 patients with 150 months\u2019 median follow-up. Endocr J 61: 491\u2013497.","DOI":"10.1507\/endocrj.EJ13-0529"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Scholfield DW, Lopez J, Eagan A, Antal Z, Tuttle RM, et al. (2023) Is multifocality a predictor of poor outcome in childhood and adolescent papillary thyroid carcinoma? J Clin Endocrinol Metab 108: 3135\u20133144.","DOI":"10.1210\/clinem\/dgad369"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Gertz RJ, Nikiforov Y, Rehrauer W, McDaniel L, Lloyd RV (2016) Mutation in BRAF and other members of the MAPK pathway in papillary thyroid carcinoma in the pediatric population. Arch Pathol Lab Med 140: 134\u2013139.","DOI":"10.5858\/arpa.2014-0612-OA"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Oishi N, Kondo T, Nakazawa T, Mochizuki K, Inoue T, et al. (2017) Frequent BRAFV600Eand absence of TERT promoter mutations characterize sporadic pediatric papillary thyroid carcinomas in Japan. Endocr Pathol 28: 103\u2013111.","DOI":"10.1007\/s12022-017-9470-y"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Chakraborty D, Shakya S, Ballal S, Agarwal S, Bal C (2020) BRAF V600E and TERT promoter mutations in paediatric and young adult papillary thyroid cancer and clinicopathological correlation. J Pediatr Endocrinol Metab 33: 1465\u20131474.","DOI":"10.1515\/jpem-2020-0174"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Kotanidou EP, Giza S, Tsinopoulou VR, Margaritis K, Papadopoulou A, et al. (2023) The prognostic significance of BRAF gene analysis in children and adolescents with papillary thyroid carcinoma: a systematic review and meta-analysis. Diagnostics (Basel) 13: 1187.","DOI":"10.3390\/diagnostics13061187"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Yin D, Yu K, Lu R, Li X, Xu J, et al. (2016) Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 85: 299\u2013305.","DOI":"10.1111\/cen.13017"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Matsuse M, Mitsutake N (2023) <i>TERT<\/i> promoter mutations in thyroid cancer. Endocr J 70: 1035\u20131049.","DOI":"10.1507\/endocrj.EJ23-0136"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Yang J, Gong Y, Yan S, Chen H, Qin S, et al. (2020) Association between TERT promoter mutations and clinical behaviors in differentiated thyroid carcinoma: a systematic review and meta-analysis. Endocrine 67: 44\u201357.","DOI":"10.1007\/s12020-019-02117-2"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Liu C, Liu Z, Chen T, Zeng W, Guo Y, et al. (2016) TERT promoter mutation and its association with clinicopathological features and prognosis of papillary thyroid cancer: a meta-analysis. Sci Rep 6: 36990.","DOI":"10.1038\/srep36990"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Chung JH (2020) <i>BRAF<\/i> and <i>TERT<\/i> promoter mutations: clinical application in thyroid cancer. Endocr J 67: 577\u2013584.","DOI":"10.1507\/endocrj.EJ20-0063"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/2\/72_EJ24-0504\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T03:25:14Z","timestamp":1738985114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/2\/72_EJ24-0504\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej24-0504","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"EJ24-0504"}}