{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:45:51Z","timestamp":1788777951680,"version":"build-2803163510"},"reference-count":36,"publisher":"Japan Endocrine Society","issue":"10","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08008"],"award-info":[{"award-number":["23K08008"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1507\/endocrj.ej24-0687","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T18:07:23Z","timestamp":1750183643000},"page":"1151-1161","source":"Crossref","is-referenced-by-count":1,"title":["A case of mineralocorticoid intermediate-producing sarcomatoid adrenal cortical carcinoma: case report and review of literature"],"prefix":"10.1507","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-2011","authenticated-orcid":false,"given":"Maki","family":"Kanzawa","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan"},{"name":"Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-8134","authenticated-orcid":false,"given":"Masaaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nishigaki","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-653X","authenticated-orcid":false,"given":"Hidenori","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Terakawa","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Ghosh C, Hu J, Kebebew E (2023) Advances in translational research of the rare cancer type adrenocortical carcinoma. Nat Rev Cancer 23: 805\u2013824.","DOI":"10.1038\/s41568-023-00623-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Minner S, Schreiner J, Saeger W (2021) Adrenal cancer: relevance of different grading systems and subtypes. Clin Transl Oncol 23: 1350\u20131357.","DOI":"10.1007\/s12094-020-02524-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Sada A, Foster TR, Al-Ward R, Sawani S, Charchar H, et al. (2024) The effect of hormonal secretion on survival in adrenocortical carcinoma: A multi-center study. Surgery 175: 80\u201389.","DOI":"10.1016\/j.surg.2023.04.070"},{"key":"4","unstructured":"4 Mark D, Boyd C, Eatock F (2014) Adrenal sarcomatoid carcinoma: a case report and review of the literature. Ulster Med J 83: 89\u201392."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 de Krijger RR, Tischler AS, Asa SL, Lack EE, Volante M (2025) Adrenal cortical carcinoma. In: AFIP Atlases of Tumor and Non-Tumor Pathology Series 5 Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia. AFIP, Bethesda, USA: 131\u2013185.","DOI":"10.55418\/9781933477473"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Lughezzani G, Sun M, Perrotte P, Jeldres C, Alasker A, et al. (2010) The european network for the study of adrenal tumors staging system is prognostically superior to the international union against cancer-staging system: a North American validation. Eur J Cancer 46: 713\u2013719.","DOI":"10.1016\/j.ejca.2009.12.007"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Elhassan YS, Altieri B, Berhane S, Cosentini D, Calabrese A, et al. (2021) S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. Eur J Endocrinol 186: 25\u201336.","DOI":"10.1530\/EJE-21-0510"},{"key":"8","unstructured":"8 Okazumi S, Asano T, Ryu M, Nagashima T, Odaka M, et al. (1987) Surgical resection of adrenal carcinoma extending into the vena cava, right atrium and ventricle: case report and review of the literature. Nihon Geka Gakkai Zasshi 88: 231\u2013238 (In Japanese)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Collina G, Maldarizzi F, Betts CM, Eusebi V (1989) Primary sarcomatoid carcinoma of the adrenal gland. First case report. Virchows Arch A Pathol Anat Histopathol 415: 161\u2013167.","DOI":"10.1007\/BF00784354"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Decorato JW, Gruber H, Petti M, Levowitz BS (1990) Adrenal carcinosarcoma. J Surg Oncol 45: 134\u2013136.","DOI":"10.1002\/jso.2930450215"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Fischler DF, Nunez C, Levin HS, McMahon JT, Sheeler LR, et al. (1992) Adrenal carcinosarcoma presenting in a woman with clinical signs of virilization. A case report with immunohistochemical and ultrastructural findings. Am J Surg Pathol 16: 626\u2013631.","DOI":"10.1097\/00000478-199206000-00011"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Barksdale SK, Marincola FM, Jaffe G (1993) Carcinosarcoma of the adrenal cortex presenting with mineralocorticoid excess. Am J Surg Pathol 17: 941\u2013945.","DOI":"10.1097\/00000478-199309000-00012"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Lee MS, Park IA, Chi JG, Ham EK, Lee KC, et al. (1997) Adrenal carcinosarcoma\u2014a case report. J Korean Med Sci 12: 374\u2013377.","DOI":"10.3346\/jkms.1997.12.4.374"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Sturm N, Moulai N, Laverri\u00e8re MH, Chabre O, Descotes JL, et al. (2008) Primary adrenocortical sarcomatoid carcinoma: case report and review of literature. Virchows Arch 452: 215\u2013219.","DOI":"10.1007\/s00428-007-0536-y"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Coli A, Di Giorgio A, Castri F, Destito C, Marin AW, et al. (2010) Sarcomatoid carcinoma of the adrenal gland: A case report and review of literature. Pathol Res Pract 206: 59\u201365.","DOI":"10.1016\/j.prp.2009.02.012"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Sasaki K, Desimone M, Rao HR, Huang GJ, Seethala RR (2010) Adrenocortical carcinosarcoma: a case report and review of the literature. Diagn Pathol 5: 51.","DOI":"10.1186\/1746-1596-5-51"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Yan JJ, Sun AJ, Ren Y, Hou C (2012) Primary adrenocortical sarcomatoid carcinoma: report of a case. Can Urol Assoc J 6: E189\u2013E191.","DOI":"10.5489\/cuaj.11137"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Bertolini F, Rossi G, Fiocchi F, Giacometti M, Fontana A, et al. (2011) Primary adrenal gland carcinosarcoma associated with metastatic rectal cancer: a hitherto unreported collision tumor. Tumori 97: 27e\u201330e.","DOI":"10.1177\/030089161109700526"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Thway K, Olmos D, Shah C, Flora R, Shipley J, et al. (2012) Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases. Am J Surg Pathol 36: 470\u2013477.","DOI":"10.1097\/PAS.0b013e31824517d9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Kao CS, Grignon DJ, Ulbright TM, Idrees MT (2013) A case report of adrenocortical carcinosarcoma with oncocytic and primitive neuroectodermal-like features. Hum Pathol 44: 1947\u20131955.","DOI":"10.1016\/j.humpath.2013.01.019"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Shaikh AS, Bakhshi GD, Khan AS, Jamadar NM, Nirmala AK, et al. (2014) Primary adrenal sarcomatoid carcinoma. Clin Pract 4: 604.","DOI":"10.4081\/cp.2014.604"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Wei YB, Gao YL, Wu HT, Ou-Yang SF, Xu T, et al. (2015) Rare incidence of primary adrenocortical carcinosarcoma: a case report and literature review. Oncol Lett 9: 153\u2013158.","DOI":"10.3892\/ol.2014.2635"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Ishikawa N, Nagase M, Takami S, Araki A, Ishikawa N, et al. (2016) A case report of bilateral sarcomatoid carcinoma of adrenal glands with adrenal insufficiency. Int J Surg Pathol 24: 743\u2013748.","DOI":"10.1177\/1066896916657589"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Turhan Iyidir O, Cerit ET, \u00d6zkan \u00c7, Alt\u0131nova E, \u00c7imen AR, et al. (2016) A case report of bilateral adrenal sarcomatoid carcinoma. Case Rep Surg 2016: 3768258.","DOI":"10.1155\/2016\/3768258"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Papathomas TG, Duregon E, Korpershoek E, Restuccia DF, van Marion R, et al. (2016) Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis. Hum Pathol 58: 113\u2013122.","DOI":"10.1016\/j.humpath.2016.08.006"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Saeger W, Mohren W, Behrend M, Iglauer P, Wilczak W (2017) Sarcomatoid adrenal carcinoma: case report with contribution to pathogenesis. Endocr Pathol 28: 139\u2013145.","DOI":"10.1007\/s12022-016-9450-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Sung TY, Choi YM, Kim WG, Lee YM, Kim TY, et al. (2017) Myxoid and sarcomatoid variants of adrenocortical carcinoma: analysis of rare variants in single tertiary care center. J Korean Med Sci 32: 764\u2013771.","DOI":"10.3346\/jkms.2017.32.5.764"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Sabrine D, Zakia B, Kaoutar Z (2020) Adrenocortical sarcomatoid carcinoma: a case report and review of the literature. J Surg Case Rep 2020: rjaa211.","DOI":"10.1093\/jscr\/rjaa211"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Zhang J, Gong W, Zhang W, Zhang C, Zhang G (2022) Primary adrenal sarcomatoid carcinoma detected by 18F-FDG PET\/CT. Clin Nucl Med 47: 433\u2013434.","DOI":"10.1097\/RLU.0000000000004068"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Branham Z, Fox AD, Ullah A, Patel NG, Terris M, et al. (2022) Insights into clinical features and outcomes of adrenal cortical carcinosarcoma. Diagnostics (Basel) 12: 2419.","DOI":"10.3390\/diagnostics12102419"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Mete O, Asa SL, Giordano TJ, Papotti M, Sasano H, et al. (2018) Immunohistochemical biomarkers of adrenal cortical neoplasms. Endocr Pathol 29: 137\u2013149.","DOI":"10.1007\/s12022-018-9525-8"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Duregon E, Volante M, Giorcelli J, Terzolo M, Lalli E, et al. (2013) Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates. Hum Pathol 44: 822\u2013828.","DOI":"10.1016\/j.humpath.2012.07.025"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, et al. (2022) Overview of the 2022 WHO classification of adrenal cortical tumors. Endocr Pathol 33: 155\u2013196.","DOI":"10.1007\/s12022-022-09710-8"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Weiss LM, Medeiros LJ, Vickery AL Jr. (1989) Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 13: 202\u2013206.","DOI":"10.1097\/00000478-198903000-00004"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, et al. (2022) Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism. J Steroid Biochem Mol Biol 221: 106116.","DOI":"10.1016\/j.jsbmb.2022.106116"},{"key":"36","unstructured":"36 Sasano H, Miyazaki S, Sawai T, Sasano N, Nagura H, et al. (1992) Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and <i>in situ<\/i> hybridization analysis of steroidogenic enzymes in eight cases. Mod Pathol 5: 23\u201329."}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/10\/72_EJ24-0687\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:55:52Z","timestamp":1759550152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/10\/72_EJ24-0687\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej24-0687","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"EJ24-0687"}}