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Front Endocrinol (Lausanne) 15: 1445633.","DOI":"10.3389\/fendo.2024.1445633"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Al-Salameh A, Cadiot G, Calender A, Goudet P, Chanson P (2021) Clinical aspects of multiple endocrine neoplasia type 1. Nat Rev Endocrinol 17: 207\u2013224.","DOI":"10.1038\/s41574-021-00468-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Waguespack SG (2022) Beyond the \u201c3 Ps\u201d: a critical appraisal of the non-endocrine manifestations of multiple endocrine neoplasia type 1. Front Endocrinol (Lausanne) 13: 1029041.","DOI":"10.3389\/fendo.2022.1029041"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Sakurai A, Suzuki S, Kosugi S, Okamoto T, Uchino S, et al. (2012) Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database. Clin Endocrinol (Oxf) 76: 533\u2013539.","DOI":"10.1111\/j.1365-2265.2011.04227.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 de Laat JM, Pieterman CR, van den Broek MF, Twisk JW, Hermus AR, et al. (2014) Natural course and survival of neuroendocrine tumors of thymus and lung in MEN1 patients. J Clin Endocrinol Metab 99: 3325\u20133333.","DOI":"10.1210\/jc.2014-1560"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Yliaska I, Tokola H, Ebeling T, Kuismin O, Ukkola O, et al. (2022) Thymic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. Endocrine 77: 527\u2013537.","DOI":"10.1007\/s12020-022-03099-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Sakurai A, Imai T, Kikumori T, Horiuchi K, Okamoto T, et al. (2013) Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions. Clin Endocrinol (Oxf) 78: 248\u2013254.","DOI":"10.1111\/j.1365-2265.2012.04467.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Tsukada T, Nagamura Y, Ohkura N (2009) MEN1 gene and its mutations: basic and clinical implications. Cancer Sci 100: 209\u2013215.","DOI":"10.1111\/j.1349-7006.2008.01034.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Effraimidis G, Knigge U, Rossing M, Oturai P, Rasmussen \u00c5K, et al. (2022) Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs). Semin Cancer Biol 79: 141\u2013162.","DOI":"10.1016\/j.semcancer.2021.04.011"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Matkar S, Thiel A, Hua X (2013) Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci 38: 394\u2013402.","DOI":"10.1016\/j.tibs.2013.05.005"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Newey PJ, Newell-Price J (2022) MEN1 surveillance guidelines: time to (re)think? J Endocr Soc 6: bvac001.","DOI":"10.1210\/jendso\/bvac001"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, et al. (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86: 5658\u20135671.","DOI":"10.1210\/jcem.86.12.8070"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16 DeLellis RA, Mangray S (2018) Heritable forms of primary hyperparathyroidism: a current perspective. Histopathology 72: 117\u2013132.","DOI":"10.1111\/his.13306"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Richards S, Aziz N, Bale S, Bick D, Das S, et al. (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17: 405\u2013424.","DOI":"10.1038\/gim.2015.30"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Romanet P, Mohamed A, Giraud S, Odou MF, North MO, et al. (2019) UMD-MEN1 database: an overview of the 370 MEN1 variants present in 1676 patients from the French population. J Clin Endocrinol Metab 104: 753\u2013764.","DOI":"10.1210\/jc.2018-01170"},{"key":"19","unstructured":"19 ClinVar. https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/ accessed on February 6, 2025."},{"key":"20","unstructured":"20 The UMD- MEN1 mutations database. http:\/\/www.umd.be\/MEN1\/ accessed on February 6, 2025."},{"key":"21","unstructured":"21 The Human Gene Mutation Database professional. https:\/\/my.qiagendigitalinsights.com\/bbp\/view\/hgmd\/pro accessed on February 6, 2025."},{"key":"22","unstructured":"22 Mutation taster. https:\/\/www.mutationtaster.org\/ accessed on February 6, 2025."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Kurosaki T, Maquat LE (2016) Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci 129: 461\u2013467.","DOI":"10.1242\/jcs.181008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Zetoune AB, Fontani\u00e8re S, Magnin D, Anczuk\u00f3w O, Buisson M, et al. (2008) Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues. BMC Genet 9: 83.","DOI":"10.1186\/1471-2156-9-83"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Bartsch DK, Slater EP, Albers M, Knoop R, Chaloupka B, et al. (2014) Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain. J Clin Endocrinol Metab 99: E2387\u2013E2391.","DOI":"10.1210\/jc.2013-4432"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Thevenon J, Bourredjem A, Faivre L, Cardot-Bauters C, Calender A, et al. (2013) Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d\u2019etude des Tumeurs Endocrines (GTE) cohort study. Hum Mol Genet 22: 1940\u20131948.","DOI":"10.1093\/hmg\/ddt039"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Lemos MC, Thakker RV (2008) Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat 29: 22\u201332.","DOI":"10.1002\/humu.20605"},{"key":"28","unstructured":"28 Kim H, Lee JE, Cho EJ, Liu JO, Youn HD (2003) Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res 63: 6135\u20136139."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, et al. (2003) Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Proc Natl Acad Sci U S A 100: 10770\u201310775.","DOI":"10.1073\/pnas.1834524100"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Chandrasekharappa SC, Teh BT (2003) Functional studies of the MEN1 gene. J Intern Med 253: 606\u2013615.","DOI":"10.1046\/j.1365-2796.2003.01165.x"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31 Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, et al. (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482: 542\u2013546.","DOI":"10.1038\/nature10806"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32 Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, et al. (1999) Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96: 143\u2013152.","DOI":"10.1016\/S0092-8674(00)80967-8"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Gobl AE, Berg M, Lopez-Egido JR, Oberg K, Skogseid B, et al. (1999) Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. Biochim Biophys Acta 1447: 51\u201356.","DOI":"10.1016\/S0167-4781(99)00132-3"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Brown MR, Soto-Feliciano YM (2025) Menin: from molecular insights to clinical impact. Epigenomics 17: 489\u2013505.","DOI":"10.1080\/17501911.2025.2485019"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Kouvaraki MA, Lee JE, Shapiro SE, Gagel RF, Sherman SI, et al. (2002) Genotype-phenotype analysis in multiple endocrine neoplasia type 1. Arch Surg 137: 641\u2013647.","DOI":"10.1001\/archsurg.137.6.641"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Mele C, Mencarelli M, Caputo M, Mai S, Pagano L, et al. (2020) Phenotypes associated with MEN1 syndrome: a focus on genotype-phenotype correlations. 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