{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:08:05Z","timestamp":1764997685654,"version":"3.46.0"},"reference-count":32,"publisher":"Japan Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1507\/endocrj.ej25-0164","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T22:09:47Z","timestamp":1753999787000},"page":"1369-1376","source":"Crossref","is-referenced-by-count":2,"title":["A case of Hailey\u2013Hailey disease accompanied by Cushing\u2019s syndrome and adrenal insufficiency due to long-term usage of topical steroids with review of literature"],"prefix":"10.1507","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-359X","authenticated-orcid":false,"given":"Yuichiro","family":"Iwamoto","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Komi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-8698","authenticated-orcid":false,"given":"Yoshiro","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-9494","authenticated-orcid":false,"given":"Tomohiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4223-9613","authenticated-orcid":false,"given":"Masashi","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-9632","authenticated-orcid":false,"given":"Shuhei","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5575","authenticated-orcid":false,"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoatsu","family":"Mune","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-1943","authenticated-orcid":false,"given":"Hideaki","family":"Kaneto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Le Sach\u00e9-de Peufeilhoux L, Raynaud E, Bouchardeau A, Fraitag S, Bodemer C (2014) Familial benign chronic pemphigus and doxycycline: a review of 6 cases. J Eur Acad Dermatol Venereol 28: 370\u2013373.","DOI":"10.1111\/jdv.12016"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Szigeti R, Kellermayer R (2006) Autosomal-dominant calcium ATPase disorders. J Invest Dermatol 126: 2370\u20132376.","DOI":"10.1038\/sj.jid.5700447"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Hailey H, Hailey H (1939) Familial benign chronic pemphigus. Arch Derm Syphilol 39: 679\u2013685.","DOI":"10.1001\/archderm.1939.01480220064005"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Porro AM, Arai Seque C, Miyamoto D, Vanderlei Medeiros da N\u00f3brega D, Sim\u00f5es ESEMM, et al. (2024) Hailey-Hailey disease: clinical, diagnostic and therapeutic update. An Bras Dermatol 99: 651\u2013661.","DOI":"10.1016\/j.abd.2023.12.003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Burge SM (1992) Hailey-Hailey disease: the clinical features, response to treatment and prognosis. Br J Dermatol 126: 275\u2013282.","DOI":"10.1111\/j.1365-2133.1992.tb00658.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Naidoo K, Tighe I, Barrett P, Bajaj V (2019) Acitretin as a successful treatment for Hailey-Hailey disease. Clin Exp Dermatol 44: 450\u2013452.","DOI":"10.1111\/ced.13762"},{"key":"7","unstructured":"7 Nakamura M, Abrouk M, Zhu H, Farahnik B, Koo J, et al. (2017) Update on the systemic risks of superpotent topical steroids. J Drugs Dermatol 16: 643\u2013648."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Tempark T, Phatarakijnirund V, Chatproedprai S, Watcharasindhu S, Supornsilchai V, et al. (2010) Exogenous Cushing\u2019s syndrome due to topical corticosteroid application: case report and review literature. Endocrine 38: 328\u2013334.","DOI":"10.1007\/s12020-010-9393-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Matejek N, Hoos J, Holterhus PM, Bettendorf M, Choukair D (2022) Topical glucocorticoid application causing iatrogenic Cushing\u2019s syndrome followed by secondary adrenal insufficiency in infants: two case reports. J Med Case Rep 16: 455.","DOI":"10.1186\/s13256-022-03659-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Taylor O, Mejia-Otero JD, Tannin GM, Gordon K (2020) Topical triamcinolone induced Cushing syndrome: a case report. Pediatr Dermatol 37: 582\u2013584.","DOI":"10.1111\/pde.14140"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 G\u00fcven A, G\u00fcl\u00fcmser O, Ozgen T (2007) Cushing\u2019s syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? J Pediatr Endocrinol Metab 20: 1173\u20131182.","DOI":"10.1515\/JPEM.2007.20.11.1173"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 G\u00fcven A (2020) Different potent glucocorticoids, different routes of exposure but the same result: iatrogenic Cushing\u2019s syndrome and adrenal insufficiency. J Clin Res Pediatr Endocrinol 12: 383\u2013392.","DOI":"10.4274\/jcrpe.galenos.2020.2019.0220"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Al-Khenaizan S, Al Alwan I (2008) Topical steroid-induced Cushing syndrome. Ann Saudi Med 28: 300\u2013302.","DOI":"10.5144\/0256-4947.2008.300"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Notay M, Fazel N, Awasthi S (2019) Cushing syndrome induced by topical corticosteroids for the treatment of lichen sclerosus. J Pediatr Adolesc Gynecol 32: 83\u201385.","DOI":"10.1016\/j.jpag.2018.09.004"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15 B\u00f6ckle BC, Jara D, Nindl W, Aberer W, Sepp NT (2014) Adrenal insufficiency as a result of long-term misuse of topical corticosteroids. Dermatology 228: 289\u2013293.","DOI":"10.1159\/000358427"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Pektas SD, Dogan G, Cinar N (2017) Iatrogenic Cushing\u2019s syndrome with subsequent adrenal insufficiency in a patient with psoriasis vulgaris using topical steroids. Case Rep Endocrinol 2017: 8320254.","DOI":"10.1155\/2017\/8320254"},{"key":"17","unstructured":"17 Abma EM, Blanken R, De Heide LJ (2002) Cushing\u2019s syndrome caused by topical steroid therapy for psoriasis. Neth J Med 60: 148\u2013150."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Young CA, Williams IR, MacFarlane IA (1991) Unrecognised Cushing\u2019s syndrome and adrenal suppression due to topical clobetasol propionate. Br J Clin Pract 45: 61\u201362.","DOI":"10.1111\/j.1742-1241.1991.tb08832.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Valette C, Ofaiche J, Severino M, Mazereeuw-Hautier J (2020) Fatal outcome of Netherton syndrome due to excessive use of topical corticosteroids in an adult patient. Ann Dermatol Venereol 147: 36\u201340 (In French).","DOI":"10.1016\/j.annder.2019.09.003"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Weber SL (1997) Cushing\u2019s syndrome attributable to topical use of lotrisone. Endocr Pract 3: 140\u2013144.","DOI":"10.4158\/EP.3.3.140"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Arya V, Sharma A, Ali M (2022) Iatrogenic Cushing\u2019s syndrome from topical steroid use. Eur J Rheumatol 9: 106\u2013107.","DOI":"10.5152\/eurjrheum.2021.20154"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Thakran P, Agrawal S, Singal A, Verma S, Madhu SV (2021) Iatrogenic Cushing\u2019s syndrome in patients with superficial dermatophytosis. Indian Dermatol Online J 12: 237\u2013243.","DOI":"10.4103\/idoj.IDOJ_432_20"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Abtahi-Naeini B, Nasri P, Afshar K, Nouri N (2024) Complicated iatrogenic Cushing\u2019s syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature. J Med Case Rep 18: 602.","DOI":"10.1186\/s13256-024-04965-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Kuikel S, Aryal S, Basnyat RS, Rimal S (2022) Cushing syndrome in a pediatric patient with topical steroid overuse. Case Rep Endocrinol 2022: 8487737.","DOI":"10.1155\/2022\/8487737"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Sachdeva S, Arora P, Kulhari A, Sardana K (2020) Iatrogenic Cushing\u2019s syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia. Dermatol Ther 33: e13514.","DOI":"10.1111\/dth.13514"},{"key":"26","unstructured":"26 Zil EAA, Janjua OH, Latif A, Aadil M (2018) Case of iatrogenic Cushing\u2019s syndrome by topical triamcinolone. J Ayub Med Coll Abbottabad 30: 121\u2013123."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Demirsoy EO, Bilen N, Akt\u00fcrk AS, Kocao\u011flu \u00d6, Mutlu GY (2014) Cushing\u2019s syndrome induced by high-potency topical corticosteroids. Int J Dermatol 53: e20\u2013e22.","DOI":"10.1111\/j.1365-4632.2011.05264.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Erdem B, Gonul M, Ozturk Unsal I, Ozdemir Sahingoz S (2024) Evaluation of psoriasis patients with long-term topical corticosteroids for their risk of developing adrenal insufficiency, Cushing\u2019s syndrome and osteoporosis. J Dermatolog Treat 35: 2298880.","DOI":"10.1080\/09546634.2023.2298880"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Purser JD, Riachy R, Blanton LS, Belalcazar LM (2020) Rapid development of iatrogenic Cushing syndrome in a patient on ritonavir: the adverse metabolic consequence of topical steroid use. AACE Clin Case Rep 6: e346\u2013e348.","DOI":"10.4158\/ACCR-2020-0375"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Decani S, Federighi V, Baruzzi E, Sardella A, Lodi G (2014) Iatrogenic Cushing\u2019s syndrome and topical steroid therapy: case series and review of the literature. J Dermatolog Treat 25: 495\u2013500.","DOI":"10.3109\/09546634.2012.755252"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, et al. (2009) Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis 68: 1119\u20131124.","DOI":"10.1136\/ard.2008.092163"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Broersen LH, Pereira AM, J\u00f8rgensen JO, Dekkers OM (2015) Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab 100: 2171\u20132180.","DOI":"10.1210\/jc.2015-1218"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/12\/72_EJ25-0164\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:38:08Z","timestamp":1764992288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj\/72\/12\/72_EJ25-0164\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.ej25-0164","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"type":"print","value":"0918-8959"},{"type":"electronic","value":"1348-4540"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"EJ25-0164"}}