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(2002) Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Lett 515: 109\u2013113.","DOI":"10.1016\/S0014-5793(02)02449-3"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Ismaeel A, Peck BD, Montgomery MM, Burke BI, Goh J, et al. (2025) microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism. Mol Metab 98: 102182.","DOI":"10.1016\/j.molmet.2025.102182"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Tang Y, Zong H, Kwon H, Qiu Y, Pessin JB, et al. (2022) TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling. Elife 11: e73360.","DOI":"10.7554\/eLife.73360"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Sharma AK, Khandelwal R, Wolfrum C (2024) Futile cycles: emerging utility from apparent futility. 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(2021) Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy <i>via<\/i> NEDD4\/KLF15 axis. J Cachexia Sarcopenia Muscle 12: 493\u2013505.","DOI":"10.1002\/jcsm.12677"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Wang DT, Yang YJ, Huang RH, Zhang ZH, Lin X (2015) Myostatin activates the ubiquitin-proteasome and autophagy-lysosome systems contributing to muscle wasting in chronic kidney disease. Oxid Med Cell Longev 2015: 684965.","DOI":"10.1155\/2015\/684965"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 J\u00e4ger S, Handschin C, St-Pierre J, Spiegelman BM (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle <i>via<\/i> direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 104: 12017\u201312022.","DOI":"10.1073\/pnas.0705070104"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47 Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. 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(2013) Autophagic flux and oxidative capacity of skeletal muscles during acute starvation. Autophagy 9: 1604\u20131620.","DOI":"10.4161\/auto.25955"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52 Xie G, Jin H, Mikhail H, Pavel V, Yang G, et al. (2023) Autophagy in sarcopenia: possible mechanisms and novel therapies. Biomed Pharmacother 165: 115147.","DOI":"10.1016\/j.biopha.2023.115147"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53 Zhang XM, Chen D, Xie XH, Zhang JE, Zeng Y, et al. (2021) Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis. BMC Geriatr 21: 339.","DOI":"10.1186\/s12877-021-02276-w"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54 Wang H, Yang R, Xu J, Fang K, Abdelrahim M, et al. (2021) Sarcopenia as a predictor of postoperative risk of complications, mortality and length of stay following gastrointestinal oncological surgery. 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Acta Physiol (Oxf) 238: e13986.","DOI":"10.1111\/apha.13986"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70 Liu Y, Cao X, Zhou Q, Deng C, Yang Y, et al. (2024) Mechanisms and countermeasures for muscle atrophy in microgravity. Cells 13: 2120.","DOI":"10.3390\/cells13242120"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71 Larson KR, Jayakrishnan D, Soto Sauza KA, Goodson ML, Chaffin AT, et al. (2024) FGF21 induces skeletal muscle atrophy and increases amino acids in female mice: a potential role for glucocorticoids. Endocrinology 165: bqae004.","DOI":"10.1210\/endocr\/bqae004"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72 Anderson KJ, Vermillion KL, Jagtap P, Johnson JE, Griffin TJ, et al. (2016) Proteogenomic analysis of a hibernating mammal indicates contribution of skeletal muscle physiology to the hibernation phenotype. J Proteome Res 15: 1253\u20131261.","DOI":"10.1021\/acs.jproteome.5b01138"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73 Shimozuru M, Kamine A, Tsubota T (2012) Changes in expression of hepatic genes involved in energy metabolism during hibernation in captive, adult, female Japanese black bears (Ursus thibetanus japonicus). Comp Biochem Physiol B Biochem Mol Biol 163: 254\u2013261.","DOI":"10.1016\/j.cbpb.2012.06.007"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74 Fedorov VB, Goropashnaya AV, T\u00f8ien \u00d8, Stewart NC, Chang C, et al. (2011) Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus). BMC Genomics 12: 171.","DOI":"10.1186\/1471-2164-12-171"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75 Welinder KG, Hansen R, Overgaard MT, Brohus M, S\u00f8nderk\u00e6r M, et al. (2016) Biochemical foundations of health and energy conservation in hibernating free-ranging subadult brown bear ursus arctos. J Biol Chem 291: 22509\u201322523.","DOI":"10.1074\/jbc.M116.742916"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76 Vella CA, Nelson OL, Jansen HT, Robbins CT, Jensen AE, et al. (2020) Regulation of metabolism during hibernation in brown bears (Ursus arctos): Involvement of cortisol, PGC-1\u03b1 and AMPK in adipose tissue and skeletal muscle. Comp Biochem Physiol A Mol Integr Physiol 240: 110591.","DOI":"10.1016\/j.cbpa.2019.110591"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77 Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, et al. (2013) Activation of serum\/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med 5: 80\u201391.","DOI":"10.1002\/emmm.201201443"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78 Galster W, Morrison PR (1975) Gluconeogenesis in arctic ground squirrels between periods of hibernation. Am J Physiol 228: 325\u2013330.","DOI":"10.1152\/ajplegacy.1975.228.1.325"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79 Chazarin B, Storey KB, Ziemianin A, Chanon S, Plumel M, et al. (2019) Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle. Front Zool 16: 12.","DOI":"10.1186\/s12983-019-0312-2"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80 Miyazaki M, Shimozuru M, Kitaoka Y, Takahashi K, Tsubota T (2022) Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation. Sci Rep 12: 19723.","DOI":"10.1038\/s41598-022-24251-0"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81 Lohuis TD, Harlow HJ, Beck TD (2007) Hibernating black bears (Ursus americanus) experience skeletal muscle protein balance during winter anorexia. Comp Biochem Physiol B Biochem Mol Biol 147: 20\u201328.","DOI":"10.1016\/j.cbpb.2006.12.020"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82 Ingelson-Filpula WA, Breedon SA, Storey KB (2024) MicroRNA, myostatin, and metabolic rate depression: skeletal muscle atrophy resistance in hibernating myotis lucifugus. Cells 13: 2074.","DOI":"10.3390\/cells13242074"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83 Ivakine EA, Cohn RD (2014) Maintaining skeletal muscle mass: lessons learned from hibernation. Exp Physiol 99: 632\u2013637.","DOI":"10.1113\/expphysiol.2013.074344"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84 Chazarin B, Ziemianin A, Evans AL, Meugnier E, Loizon E, et al. (2019) Limited oxidative stress favors resistance to skeletal muscle atrophy in hibernating brown bears (Ursus arctos). Antioxidants (Basel) 8: 334.","DOI":"10.3390\/antiox8090334"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85 Xu R, Andres-Mateos E, Mejias R, MacDonald EM, Leinwand LA, et al. (2013) Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Exp Neurol 247: 392\u2013401.","DOI":"10.1016\/j.expneurol.2013.01.005"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86 Stewart MA, Franks-Skiba K, Chen S, Cooke R (2010) Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers. Proc Natl Acad Sci U S A 107: 430\u2013435.","DOI":"10.1073\/pnas.0909468107"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87 De Napoli C, Schmidt L, Montesel M, Cussonneau L, Sanniti S, et al. (2025) Reduced ATP turnover during hibernation in relaxed skeletal muscle. Nat Commun 16: 80.","DOI":"10.1038\/s41467-024-55565-4"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88 Izumi-Mishima Y, Tsutsumi R, Shiuchi T, Fujimoto S, Taniguchi M, et al. (2025) Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. Elife 13: RP99982.","DOI":"10.7554\/eLife.99982.3"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89 Cutler HB, Jall-Rogg S, Thillainadesan S, Cooke KC, Masson SWC, et al. (2025) Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue. Sci Adv 11: eadt7369.","DOI":"10.1126\/sciadv.adt7369"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90 Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, et al. (2020) pH-gated succinate secretion regulates muscle remodeling in response to exercise. Cell 183: 62\u201375.e17.","DOI":"10.1016\/j.cell.2020.08.039"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91 Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, et al. (2018) Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 560: 102\u2013106.","DOI":"10.1038\/s41586-018-0353-2"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92 Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6: a016295.","DOI":"10.1101\/cshperspect.a016295"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93 de Oliveira Dos Santos AR, de Oliveira Zanuso B, Miola VFB, Barbalho SM, Santos Bueno PC, et al. (2021) Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions. Int J Mol Sci 22: 2639.","DOI":"10.3390\/ijms22052639"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94 Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, et al. (2020) Origin and function of stress-induced IL-6 in murine models. Cell 182: 372\u2013387.e314.","DOI":"10.1016\/j.cell.2020.05.054"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95 Ikeda SI, Tamura Y, Kakehi S, Sanada H, Kawamori R, et al. (2016) Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 473: 947\u2013952.","DOI":"10.1016\/j.bbrc.2016.03.159"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96 Bonetto A, Aydogdu T, Jin X, Zhang Z, Zhan R, et al. (2012) JAK\/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia. Am J Physiol Endocrinol Metab 303: E410\u2013E421.","DOI":"10.1152\/ajpendo.00039.2012"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97 Zanders L, Kny M, Hahn A, Schmidt S, Wundersitz S, et al. (2022) Sepsis induces interleukin 6, gp130\/JAK2\/STAT3, and muscle wasting. J Cachexia Sarcopenia Muscle 13: 713\u2013727.","DOI":"10.1002\/jcsm.12867"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98 Pettersen K, Andersen S, Degen S, Tadini V, Grosjean J, et al. (2017) Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling. Sci Rep 7: 2046.","DOI":"10.1038\/s41598-017-02088-2"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99 Liu Y, Guo Y, Liu Z, Feng X, Zhou R, et al. (2023) Augmented temperature fluctuation aggravates muscular atrophy through the gut microbiota. Nat Commun 14: 3494.","DOI":"10.1038\/s41467-023-39171-4"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100 Sepulveda J, Moeller AH (2020) The effects of temperature on animal gut microbiomes. Front Microbiol 11: 384.","DOI":"10.3389\/fmicb.2020.00384"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101 Zhang XY, Wang DH (2022) Gut microbial community and host thermoregulation in small mammals. Front Physiol 13: 888324.","DOI":"10.3389\/fphys.2022.888324"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102 Bongers KS, Chanderraj R, Woods RJ, McDonald RA, Adame MD, et al. (2023) The gut microbiome modulates body temperature both in sepsis and health. Am J Respir Crit Care Med 207: 1030\u20131041.","DOI":"10.1164\/rccm.202201-0161OC"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103 Gizard F, Fernandez A, De Vadder F (2020) Interactions between gut microbiota and skeletal muscle. Nutr Metab Insights 13: 1178638820980490.","DOI":"10.1177\/1178638820980490"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104 Li Z, Wen M, Tang C, Chen S, Tang D, et al. (2025) Gut microbiota orchestrates skeletal muscle development and metabolism in germ-free and SPF pigs. Front Microbiol 16: 1615884.","DOI":"10.3389\/fmicb.2025.1615884"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105 Yoshihara I, Kondo Y, Okamoto K, Tanaka H (2023) Sepsis-associated muscle wasting: a comprehensive review from bench to bedside. Int J Mol Sci 24: 5040.","DOI":"10.3390\/ijms24055040"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106 Dombrecht D, Van Daele U, Van Asbroeck B, Schieffelers D, Guns PJ, et al. (2023) Molecular mechanisms of post-burn muscle wasting and the therapeutic potential of physical exercise. J Cachexia Sarcopenia Muscle 14: 758\u2013770.","DOI":"10.1002\/jcsm.13188"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107 Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, et al. (2021) Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care 11: 104.","DOI":"10.1186\/s13613-021-00893-7"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108 Tamai S, Fujita SI, Komine R, Kanki Y, Aoki K, et al. (2022) Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish. Biochem Biophys Res Commun 608: 59\u201365.","DOI":"10.1016\/j.bbrc.2022.03.093"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109 Manfredi LH, Zanon NM, Gar\u00f3falo MA, Navegantes LC, Kettelhut IC (2013) Effect of short-term cold exposure on skeletal muscle protein breakdown in rats. J Appl Physiol 115: 1496\u20131505.","DOI":"10.1152\/japplphysiol.00474.2013"},{"key":"110","doi-asserted-by":"crossref","unstructured":"110 Wilson MM, Morley JE (2003) Invited review: aging and energy balance. J Appl Physiol 95: 1728\u20131736.","DOI":"10.1152\/japplphysiol.00313.2003"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111 Silva GDN, Amato AA (2022) Thermogenic adipose tissue aging: Mechanisms and implications. Front Cell Dev Biol 10: 955612.","DOI":"10.3389\/fcell.2022.955612"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112 Hirano T (2021) IL-6 in inflammation, autoimmunity and cancer. Int Immunol 33: 127\u2013148.","DOI":"10.1093\/intimm\/dxaa078"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113 Unver N, McAllister F (2018) IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev 41: 10\u201317.","DOI":"10.1016\/j.cytogfr.2018.04.004"},{"key":"114","doi-asserted-by":"publisher","unstructured":"114 Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A (2013) Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes 62: 355\u2013361.","DOI":"10.2337\/db11-1790"},{"key":"115","doi-asserted-by":"publisher","unstructured":"115 He C, Sumpter R, Jr., Levine B (2012) Exercise induces autophagy in peripheral tissues and in the brain. Autophagy 8: 1548\u20131551.","DOI":"10.4161\/auto.21327"},{"key":"116","doi-asserted-by":"publisher","unstructured":"116 He C, Bassik MC, Moresi V, Sun K, Wei Y, et al. (2012) Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481: 511\u2013515.","DOI":"10.1038\/nature10758"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117 Suryani D, Tarawan VM, Megantara I, Lesmana R, Sylviana N, et al. (2022) A narrative review: exercise induces adipose browning by altering the gut microbiome profile. Open Sports Sci J 15: E1875399X2211210.","DOI":"10.2174\/1875399X-v15-e221125-2022-28"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118 Liu Y, Ge M, Xiao X, Lu Y, Zhao W, et al. 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