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(2008) The diagnosis of Cushing\u2019s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93: 1526\u20131540.","DOI":"10.1210\/jc.2008-0125"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, et al. (2021) Consensus on diagnosis and management of Cushing\u2019s disease: a guideline update. Lancet Diabetes Endocrinol 9: 847\u2013875.","DOI":"10.1016\/S2213-8587(21)00235-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Hur KY, Kim JH, Kim BJ, Kim MS, Lee EJ, et al. (2015) Clinical Guidelines for the Diagnosis and Treatment of Cushing\u2019s Disease in Korea. 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(2016) Second-line tests in the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome. Pituitary 19: 488\u2013495.","DOI":"10.1007\/s11102-016-0729-y"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58 Aytug S, Laws ER, Jr., Vance ML (2012) Assessment of the utility of the high-dose dexamethasone suppression test in confirming the diagnosis of Cushing disease. Endocr Pract 18: 152\u2013157.","DOI":"10.4158\/EP11179.OR"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59 Lim JS, Lee SK, Kim SH, Lee EJ, Kim SH (2011) Intraoperative multiple-staged resection and tumor tissue identification using frozen sections provide the best result for the accurate localization and complete resection of tumors in Cushing\u2019s disease. Endocrine 40: 452\u2013461.","DOI":"10.1007\/s12020-011-9499-5"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60 Fukuhara N, Inoshita N, Yamaguchi-Okada M, Tatsushima K, Takeshita A, et al. 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(2023) Dexamethasone suppression for (18)F-FDG PET\/CT to localize ACTH-secreting pituitary tumors. Cancer Imaging 23: 85.","journal-title":"Cancer Imaging","ISSN":"https:\/\/id.crossref.org\/issn\/1470-7330","issn-type":"print"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64 Valizadeh M, Rahmani F, Nikoohemmat M, Ramezani Ahmadi A, Hosseinpanah F, et al. (2024) Diagnostic accuracy of the desmopressin stimulation test in the comprehensive assessment of ACTH-dependent Cushing\u2019s syndrome: a comparative analysis with BIPSS and TSS. Endocr Res 49: 232\u2013242.","DOI":"10.1080\/07435800.2024.2381720"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65 Zampetti B, Grossrubatscher E, Dalino Ciaramella P, Boccardi E, Loli P (2016) Bilateral inferior petrosal sinus sampling. Endocr Connect 5: R12\u2013R25.","DOI":"10.1530\/EC-16-0029"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66 Valizadeh M, Abiri B, Hosseinpanah F, Grossman A (2024) Bilateral inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome: a reappraisal. J Intern Med 296: 2\u201323.","DOI":"10.1111\/joim.13789"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67 Mulligan GB, Faiman C, Gupta M, Kennedy L, Hatipoglu B, et al. (2012) Prolactin measurement during inferior petrosal sinus sampling improves the localization of pituitary adenomas in Cushing\u2019s disease. Clin Endocrinol (Oxf) 77: 268\u2013274.","DOI":"10.1111\/j.1365-2265.2012.04339.x"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68 Ishida A, Asakuno K, Shiramizu H, Yoshimoto H, Nakase K, et al. (2021) Revalidation of inferior petrosal sinus sampling: the latest results from a single-center experience. 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