{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:35:14Z","timestamp":1792712114631,"version":"4.5.0"},"reference-count":51,"publisher":"Japan Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1507\/endocrj.k10e-164","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T02:30:17Z","timestamp":1276828217000},"page":"659-666","source":"Crossref","is-referenced-by-count":47,"title":["Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias"],"prefix":"10.1507","volume":"57","author":[{"given":"Akihiro","family":"Yasoda","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuwa","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nakao K, Ogawa Y, Suga S, Imura H (1992) Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides. <i>J Hypertens <\/i>10<i>:<\/i>907-912.","DOI":"10.1097\/00004872-199209000-00001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199210000-00002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.1.229"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113544"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113872"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90925-U"},{"key":"7","unstructured":"7. Mukoyama M, Nakao K, Saito Y, Ogawa Y, Hosoda K, Suga S, Shirakami G, Jougasaki M, Imura H (1990) Increased human brain natriuretic peptide in congestive heart failure. <i>N Engl J Med <\/i>323:757-758."},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115146"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Morita E, Yasue H, Yoshimura M, Ogawa H, Jougasaki M, Matsumura T, Mukoyama M, Nakao K (1993) Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction. <i>Circulation <\/i>88:82-91.","DOI":"10.1161\/01.CIR.88.1.82"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147829.78357.C5"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Arai H, Nakao K, Saito Y, Morii N, Sugawara A, Yamada T, Itoh H, Shiono S, Mukoyama M, Ohkubo H, <i>et al. <\/i>(1988) Augmented expression of atrial natriuretic polypeptide gene in ventricles of spontaneously hypertensive rats (SHR) and SHR-stroke prone. <i>Circ Res <\/i>62:926-930.","DOI":"10.1161\/01.RES.62.5.926"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, Nakao K (1994) Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. <i>Circulation <\/i>90:195-203.","DOI":"10.1161\/01.CIR.90.1.195"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Sugawara A, Nakao K, Sakamoto M, Morii N, Yamada T, Itoh H, Shiono S, Imura H (1985) Plasma concentration of atrial natriuretic polypeptide in essential hypertension. <i>Lancet <\/i>Dec 21-28;2:1426-1427.","DOI":"10.1016\/S0140-6736(85)92592-9"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114134"},{"key":"15","unstructured":"15. Ogawa Y, Nakao K, Mukoyama M, Hosoda K, Shirakami G, Arai H, Saito Y, Suga S, Jougasaki M, Imura H (1991) Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide. <i>Circ Res <\/i>69:491-500."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Saito Y, Nakao K, Nishimura K, Sugawara A, Okumura K, Obata K, Sonoda R, Ban T, Yasue H, Imura H (1987) Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function. <i>Circulation <\/i>76:115-124.","DOI":"10.1161\/01.CIR.76.1.115"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Yoshimura M, Yasue H, Morita E, Sakaino N, Jougasaki M, Kurose M, Mukoyama M, Saito Y, Nakao K, Imura H (1991) Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. <i>Circulation <\/i>84:1581-1588.","DOI":"10.1161\/01.CIR.84.4.1581"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92401-K"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N, et al. (1991) C-type natriuretic peptide (CNP) in rats and humans. <i>Endocrinology <\/i>129:1104-1106.","DOI":"10.1210\/endo-129-2-1104"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115933"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/en.133.6.3038"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Doi K, Itoh H, Komatsu Y, Igaki T, Chun T H, Takaya K, Yamashita J, Inoue M, Yoshimasa T, Nakao K (1996) Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion. <i>Hypertension <\/i>27:811-815.","DOI":"10.1161\/01.HYP.27.3.811"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kubo A, Isumi Y, Ishizaka Y, Tomoda Y, Kangawa K, Dohi K, Matsuo H, Minamino N (2001) C-type natriuretic peptide is synthesized and secreted from leukemia cell lines, peripheral blood cells, and peritoneal macrophages. <i>Exp Hematol <\/i>29:609-615.","DOI":"10.1016\/S0301-472X(01)00625-7"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071389098"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nature01657"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407894101"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Yasoda A, Komatsu Y, Chusho H, Miyazawa T, Ozasa A, Miura M, Kurihara T, Rogi T, Tanaka S, Suda M, Tamura N, Ogawa Y, Nakao K (2004) Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. <i>Nat Med <\/i>10:80-86.","DOI":"10.1038\/nm971"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Feil R, Lohmann S M, de Jonge H, Walter U, Hofmann F (2003) Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. <i>Circ Res <\/i>93:907-916.","DOI":"10.1161\/01.RES.0000100390.68771.CC"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2082"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220307"},{"key":"31","unstructured":"31. Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett J R, Nakamura K, Chung U I, Kawaguchi H (2008) Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. <i>J Clin Invest <\/i>118:2506-2515."},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7403"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708596200"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500024200"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Sogawa C, Tsuji T, Shinkai Y, Katayama K, Kunieda T (2007) Short-limbed dwarfism: slw is a new allele of Npr2 causing chondrodysplasia. <i>J Hered <\/i>98<i>:<\/i>575-580.","DOI":"10.1093\/jhered\/esm065"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.08.139"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Jiao Y, Yan J, Jiao F, Yang H, Donahue L R, Li X, Roe B A, Stuart J, Gu W (2007) A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice. <i>BMC Genet <\/i>8:16.","DOI":"10.1186\/1471-2156-8-16"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1224204"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10278"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1086\/422013"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Olney R C, Bukulmez H, Bartels C F, Prickett T C, Espiner E A, Potter L R, Warman M L (2006) Heterozygous mutations in natriuretic peptide receptor- B (NPR2) are associated with short stature. <i>J Clin Endocrinol Metab <\/i>91:1229-1232.","DOI":"10.1210\/jc.2005-1949"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Bocciardi R, Giorda R, Buttgereit J, Gimelli S, Divizia M T, Beri S, Garofalo S, Tavella S, Lerone M, Zuffardi O, Bader M, Ravazzolo R, Gimelli G (2007) Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation. <i>Hum Mutat <\/i>28:724-731.","DOI":"10.1002\/humu.20511"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Moncla A, Missirian C, Cacciagli P, Balzamo E, Legeai-Mallet L, Jouve J L, Chabrol B, Le Merrer M, Plessis G, Villard L, Philip N (2007) A cluster of translocation breakpoints in 2q37 is associated with overexpression of NPPC in patients with a similar overgrowth phenotype. <i>Hum Mutat <\/i>28:1183-1188.","DOI":"10.1002\/humu.20611"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Superti-Furga A, Bonafe L, Rimoin D L (2001) Molecular-pathogenetic classification of genetic disorders of the skeleton. <i>Am J Med Genet <\/i>106<i>:<\/i>282-293.","DOI":"10.1002\/ajmg.10233"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/371252a0"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Cattaneo R, Villa A, Catagni M, Tentori L (1988) Limb lengthening in achondroplasia by Ilizarov&rsquo;s method. <i>Int Orthop <\/i>12:173-179.","DOI":"10.1007\/BF00547160"},{"key":"47","unstructured":"47. Naski M C, Ornitz D M (1998) FGF signaling in skeletal development. <i>Front Biosci <\/i>3:d781-794."},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02618"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Kake T, Kitamura H, Adachi Y, Yoshioka T, Watanabe T, Matsushita H, Fujii T, Kondo E, Tachibe T, Kawase Y, Jishage K, Yasoda A, Mukoyama M, Nakao K (2009) Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice. <i>Am J Physiol Endocrinol Metab <\/i>297:E1339-1348.","DOI":"10.1152\/ajpendo.00272.2009"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Yasoda A, Kitamura H, Fujii T, Kondo E, Murao N, Miura M, Kanamoto N, Komatsu Y, Arai H, Nakao K (2009) Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias. <i>Endocrinology <\/i>150:3138-3144.","DOI":"10.1210\/en.2008-1676"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.21.7"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/57\/8\/57_K10E-164\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T06:54:00Z","timestamp":1618296840000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/57\/8\/57_K10E-164\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.k10e-164","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}