{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:04:16Z","timestamp":1777723456919,"version":"3.51.4"},"reference-count":29,"publisher":"Japan Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1507\/endocrj.k11e-019","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T05:20:32Z","timestamp":1300339232000},"page":"343-348","source":"Crossref","is-referenced-by-count":35,"title":["Severe thyroid-associated orbitopathy in Hashimoto's thyroiditis. Report of 2 cases"],"prefix":"10.1507","volume":"58","author":[{"given":"Ai","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeduk","family":"Yoshimura Noh","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Nakachi","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Ohye","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiori","family":"Sato","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sekiya","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kosuga","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo","family":"Kunii","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Mukasa","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Olympia Eye Hospital, Tokyo 150-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Hospital, Tokyo 150-8308, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Gerding MN, van der Meer JW, Broenink M, Bakker O, Wiersinga WM, Prummel MF (2000) Association of thyrotrophin receptor antibodies with the clinical features of Graves&rsquo; ophthalmopathy. <i>Clin Endocrinol (Oxf)<\/i> 52: 267-271.","DOI":"10.1046\/j.1365-2265.2000.00959.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bartalena L (2005) Graves&rsquo; ophthalmopathy: search for shared autoantigen(s) continues. <i>J Endocrinol Invest<\/i> 28: 396-397.","DOI":"10.1007\/BF03347216"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bahn RS (2004) TSH receptor expression in orbital tissue and its role in the pathogenesis of Graves&rsquo; ophthalmopathy. <i>J Endocrinol Invest<\/i> 27: 216-220.","DOI":"10.1007\/BF03345269"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Agretti P, De Marco G, De Servi M, Marcocci C, Vitti P, Pinchera A, Tonacchera M (2005) Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation. <i>Eur J Endocrinol<\/i> 152: 777-784.","DOI":"10.1530\/eje.1.01900"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Eckstein AK, Losch C, Glowacka D, Schott M, Mann K, Esser J, Morgenthaler NG (2009) Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy. <i>Br J Ophthalmol<\/i> 93: 1052-1056.","DOI":"10.1136\/bjo.2007.137265"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Noh JY, Hamada N, Inoue Y, Abe Y, Ito K (2000) Thyroid-stimulating antibody is related to Graves&rsquo; ophthalmopathy, but thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves&rsquo; disease. <i>Thyroid<\/i> 10: 809-813.","DOI":"10.1089\/thy.2000.10.809"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bahn RS (2010) Graves&rsquo; ophthalmopathy. <i>N Engl J Med<\/i> 362: 726-738.","DOI":"10.1056\/NEJMra0905750"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tjiang H, Lahooti H, McCorquodale T, Parmar KR, Wall JR (2010) Eye and eyelid abnormalities are common in patients with Hashimoto&rsquo;s thyroiditis. <i>Thyroid<\/i> 20: 287-290.","DOI":"10.1089\/thy.2009.0199"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Grzesiuk W, Szydlarska D, Pragacz A, Bar-Andziak E (2008) Thyroid-associated orbitopathy in patients with Hashimoto&rsquo;s thyroiditis: a case report. <i>Pol Arch Med Wewn<\/i> 118: 318-321.","DOI":"10.20452\/pamw.400"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tomer Y (2000) Unilateral ophthalmopathy in a patient with Hashimoto&rsquo;s thyroiditis. <i>Thyroid<\/i> 10: 99-100.","DOI":"10.1089\/thy.2000.10.99"},{"issue":"4","key":"11","first-page":"396","volume":"28","author":"MIYAGI KOUICHI","year":"1988","ISSN":"https:\/\/id.crossref.org\/issn\/0009-918X","issn-type":"print"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199711000-00005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181ee63ce"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01053.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mehta M, Jakobiec F, Fay A (2009) Idiopathic fibroinflammatory disease of the face, eyelids, and periorbital membrane with immunoglobulin G4-positive plasma cells. <i>Arch Pathol Lab Med<\/i> 133: 1251-1255.","DOI":"10.5858\/133.8.1251"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Leo M, Pinchera A, Marcocci C (2009) Orbital lymphoma masquerading as thyroid-associated orbitopathy. <i>J Clin Endocrinol Metab<\/i> 94: 3155-3156.","DOI":"10.1210\/jc.2009-0669"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02257.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-006-0518-Y"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yamada M, Li AW, Wall JR (2000) Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management. <i>Crit Rev Clin Lab Sci<\/i> 37: 523-549.","DOI":"10.1080\/10408360091174303"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(01)00407-5"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2331047.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753600179"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bahn RS (2003) Clinical review 157: Pathophysiology of Graves&rsquo; ophthalmopathy: the cycle of disease. <i>J Clin Endocrinol Metab<\/i> 88: 1939-1946.","DOI":"10.1210\/jc.2002-030010"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Starkey KJ, Janezic A, Jones G, Jordan N, Baker G, Ludgate M (2003) Adipose thyrotrophin receptor expression is elevated in Graves&rsquo; and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo. <i>J Mol Endocrinol<\/i> 30: 369-380.","DOI":"10.1677\/jme.0.0300369"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Gopinath B, Ma G, Wall JR (2007) Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. <i>Thyroid<\/i> 17: 1123-1129.","DOI":"10.1089\/thy.2007.0054"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gopinath B, Musselman R, Adams CL, Tani J, Beard N, Wall JR (2006) Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves&rsquo; disease with and without ophthalmopathy: correlation with clinical features. <i>Thyroid<\/i> 16: 967-974.","DOI":"10.1089\/thy.2006.16.967"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Lahooti H, Parmar KR, Wall JR (2010) Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role? <i>Clin Ophthalmol<\/i> 4: 417-425.","DOI":"10.2147\/OPTH.S6534"},{"key":"28","unstructured":"28. Wall JR, Lahooti H (2010) Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? <i>Endokrynol Pol<\/i> 61: 222-227."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Miller A, Arthurs B, Boucher A, Liberman A, Bernard N, Rodien P, Salvi M, Wall JR (1992) Significance of antibodies reactive with a 64 kDa eye muscle membrane antigen in patients with thyroid autoimmunity. <i>Thyroid<\/i> 2: 197-202.","DOI":"10.1089\/thy.1992.2.197"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/58\/5\/58_K11E-019\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T15:43:45Z","timestamp":1741103025000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/58\/5\/58_K11E-019\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.k11e-019","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}